product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
0948/10
catalog :
0948/10
quantity :
10 mg (also 50 mg)
price :
236 USD
more info or order :
citations: 12
Reference
Lavine J, Farnoodian M, Wang S, Darjatmoko S, Wright L, Gamm D, et al. ?2-Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression. Invest Ophthalmol Vis Sci. 2017;58:299-308 pubmed publisher
Littmann T, Göttle M, Reinartz M, Kälble S, Wainer I, Ozawa T, et al. Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands. J Pharmacol Exp Ther. 2015;355:183-90 pubmed publisher
Suarez J, Rivera P, Arrabal S, Crespillo A, Serrano A, Baixeras E, et al. Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat. Dis Model Mech. 2014;7:129-41 pubmed publisher
Lavine J, Sang Y, Wang S, Ip M, Sheibani N. Attenuation of choroidal neovascularization by ?(2)-adrenoreceptor antagonism. JAMA Ophthalmol. 2013;131:376-82 pubmed publisher
Cai H, Xu Z, Tang J, Sun Y, Chen K, Wang H, et al. The essential role for aromatic cluster in the β3 adrenergic receptor. Acta Pharmacol Sin. 2012;33:1062-8 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Rankovic V, Landgraf P, Kanyshkova T, Ehling P, Meuth S, Kreutz M, et al. Modulation of calcium-dependent inactivation of L-type Ca2+ channels via ?-adrenergic signaling in thalamocortical relay neurons. PLoS ONE. 2011;6:e27474 pubmed publisher
Maupoil V, Bronquard C, Freslon J, Cosnay P, Findlay I. Ectopic activity in the rat pulmonary vein can arise from simultaneous activation of alpha1- and beta1-adrenoceptors. Br J Pharmacol. 2007;150:899-905 pubmed
Briones A, Daly C, Jiménez Altayó F, Martinez Revelles S, Gonzalez J, McGrath J, et al. Direct demonstration of beta1- and evidence against beta2- and beta3-adrenoceptors, in smooth muscle cells of rat small mesenteric arteries. Br J Pharmacol. 2005;146:679-91 pubmed
Brahmadevara N, Shaw A, Macdonald A. ALpha1-adrenoceptor antagonist properties of CGP 12177A and other beta-adrenoceptor ligands: evidence against beta(3)- or atypical beta-adrenoceptors in rat aorta. Br J Pharmacol. 2004;142:781-7 pubmed
Cirino G, Sorrentino R, di Villa Bianca R, Popolo A, Palmieri A, Imbimbo C, et al. Involvement of beta 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function. Proc Natl Acad Sci U S A. 2003;100:5531-6 pubmed
Steinle J, Booz G, Meininger C, Day J, Granger H. Beta 3-adrenergic receptors regulate retinal endothelial cell migration and proliferation. J Biol Chem. 2003;278:20681-6 pubmed
product information
master code :
948
SKU :
0948/10
product name :
BRL 37344, sodium salt
unit size :
10 mg (also 50 mg)
description :
3 agonist
target :
Adrenergic beta-3 Receptor Agonists
category :
Small Molecules
purity :
98%
observed molecular weight :
385.82
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
BRL 37344, sodium salt is a potent and selective 3 adrenoceptor agonist (Ki values are 287, 1750 and 1120 nM for 3, 1 and 2 receptors respectively).
top caption :
3 agonist
extended description :
3 agonist
chemical name text :
(R*,R*)-( )-4-[2-[(2-(3-Chlorophenyl)-2-hydroxyethyl)amino]propyl]phenoxyacetic acid, sodium salt
formula :
C19H21NO4ClNa
formula text :
C19H21NO4ClNa
cas num :
127299-93-8
USD :
236 USD
product details :
3 agonist
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK