product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
0947/25
catalog :
0947/25
quantity :
25 mg
price :
108 USD
more info or order :
citations: 7
Reference
Wyant G, Yu W, Doulamis I, Nomoto R, Saeed M, Duignan T, et al. Mitochondrial remodeling and ischemic protection by G protein-coupled receptor 35 agonists. Science. 2022;377:621-629 pubmed publisher
Rojewska E, CiapaƂa K, Mika J. Kynurenic acid and zaprinast diminished CXCL17-evoked pain-related behaviour and enhanced morphine analgesia in a mouse neuropathic pain model. Pharmacol Rep. 2019;71:139-148 pubmed publisher
Caltabiano G, Kent T, Jenkins L, McCallum J, Hudson B, Nicklin S, et al. The antiallergic mast cell stabilizers lodoxamide and bufrolin as the first high and equipotent agonists of human and rat GPR35. Mol Pharmacol. 2014;85:91-104 pubmed publisher
Polcari A, Farooq A, Woods M, Ripsch M, Picken M, Turk T, et al. Effect of the phosphodiesterase-5 inhibitor zaprinast on ischemia-reperfusion injury in rats. J Endourol. 2013;27:338-42 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Zerani M, Boiti C, Zampini D, Brecchia G, Dall Aglio C, Ceccarelli P, et al. Ob receptor in rabbit ovary and leptin in vitro regulation of corpora lutea. J Endocrinol. 2004;183:279-88 pubmed
Robichaud A, Savoie C, Stamatiou P, Lachance N, Jolicoeur P, Rasori R, et al. Assessing the emetic potential of PDE4 inhibitors in rats. Br J Pharmacol. 2002;135:113-8 pubmed
product information
master code :
947
SKU :
0947/25
product name :
Zaprinast
unit size :
25 mg
description :
GPR35 agonist
target :
Phosphodiesterase Inhibitors
category :
Small Molecules
purity :
98%
observed molecular weight :
271.28
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Zaprinast is a phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC50 values are 0.15, 0.76, 12.0 and 29.0 u M respectively). Putative GPR35 agonist.
top caption :
GPR35 agonist
extended description :
GPR35 agonist
chemical name text :
2-(2-Propyloxyphenyl)-8-azapurin-6-one
formula :
C13H13N5O2
formula text :
C13H13N5O2
cas num :
37762-06-4
USD :
108 USD
product details :
GPR35 agonist
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK