product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
0942/10
catalog :
0942/10
quantity :
10 mg (also 50 mg)
price :
241 USD
more info or order :
citations: 15
Reference
Messerschmidt L, Fischer S, Wiedemann P, Bringmann A, Hollborn M. Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation. Mol Vis. 2019;25:329-344 pubmed
Bonfill Teixidor E, Otxoa de Amezaga A, Font Nieves M, Sans Fons M, Planas A. Differential expression of E-type prostanoid receptors 2 and 4 in microglia stimulated with lipopolysaccharide. J Neuroinflammation. 2017;14:3 pubmed publisher
Tunaru S, Chennupati R, Nusing R, Offermanns S. Arachidonic Acid Metabolite 19(S)-HETE Induces Vasorelaxation and Platelet Inhibition by Activating Prostacyclin (IP) Receptor. PLoS ONE. 2016;11:e0163633 pubmed publisher
Ho Y, Lin Y, Wu C, Chao Y, Chang A, Chan J. Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus. J Biomed Sci. 2015;22:46 pubmed publisher
Wei S, Yu Y, Zhang Z, Felder R. Proinflammatory cytokines upregulate sympathoexcitatory mechanisms in the subfornical organ of the rat. Hypertension. 2015;65:1126-33 pubmed publisher
Liu L, Liu J, Tian X, Wong W, Lau C, Xu A, et al. Uncoupling protein-2 mediates DPP-4 inhibitor-induced restoration of endothelial function in hypertension through reducing oxidative stress. Antioxid Redox Signal. 2014;21:1571-81 pubmed publisher
Chen M, Su W, Lin X, Guo Z, Wang J, Zhang Q, et al. Adoptive transfer of human gingiva-derived mesenchymal stem cells ameliorates collagen-induced arthritis via suppression of Th1 and Th17 cells and enhancement of regulatory T cell differentiation. Arthritis Rheum. 2013;65:1181-93 pubmed publisher
Sugiyama T, Meakin L, Galea G, Lanyon L, Price J. The cyclooxygenase-2 selective inhibitor NS-398 does not influence trabecular or cortical bone gain resulting from repeated mechanical loading in female mice. Osteoporos Int. 2013;24:383-8 pubmed publisher
Font Nieves M, Sans Fons M, Gorina R, Bonfill Teixidor E, Salas Perdomo A, Márquez Kisinousky L, et al. Induction of COX-2 enzyme and down-regulation of COX-1 expression by lipopolysaccharide (LPS) control prostaglandin E2 production in astrocytes. J Biol Chem. 2012;287:6454-68 pubmed publisher
Chia E, Kagota S, Wijekoon E, McGuire J. Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice. BMC Pharmacol. 2011;11:10 pubmed publisher
Buenestado A, Grassin Delyle S, Guitard F, Naline E, Faisy C, Israel Biet D, et al. Roflumilast inhibits the release of chemokines and TNF-α from human lung macrophages stimulated with lipopolysaccharide. Br J Pharmacol. 2012;165:1877-1890 pubmed publisher
Bourquin C, Hotz C, Noerenberg D, Voelkl A, Heidegger S, Roetzer L, et al. Systemic cancer therapy with a small molecule agonist of toll-like receptor 7 can be improved by circumventing TLR tolerance. Cancer Res. 2011;71:5123-33 pubmed publisher
Sunters A, Armstrong V, Zaman G, Kypta R, Kawano Y, Lanyon L, et al. Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 r. J Biol Chem. 2010;285:8743-58 pubmed publisher
Wong S, Leung F, Lau C, Au C, Yung L, Yao X, et al. Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging. Circ Res. 2009;104:228-35 pubmed publisher
Ray N, Bisher M, Enquist L. Cyclooxygenase-1 and -2 are required for production of infectious pseudorabies virus. J Virol. 2004;78:12964-74 pubmed
product information
master code :
942
SKU :
0942/10
product name :
NS 398
unit size :
10 mg (also 50 mg)
description :
Cyclooxygenase-2 (COX-2) inhibitor
target :
Cyclooxygenase Inhibitors
category :
Small Molecules
purity :
99%
observed molecular weight :
314.36
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
NS 398 is a selective cyclooxygenase-2 inhibitor (IC50 values are 3.8 and 100 u M for COX-2 and COX-1 respectively). Induces apoptosis in colorectal tumor cells and elevates COX-2 protein expression in vitro . Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo .
top caption :
Cyclooxygenase-2 (COX-2) inhibitor
extended description :
Cyclooxygenase-2 (COX-2) inhibitor
chemical name text :
N-[2-Cyclohexyloxy-4-nitrophenyl]methanesulfonamide
formula :
C13H18N2O5S
formula text :
C13H18N2O5S
cas num :
123653-11-2
USD :
241 USD
product details :
Cyclooxygenase-2 (COX-2) inhibitor
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK