product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
MK 212 hydrochloride
catalog :
0941
quantity :
10 mg (also 50 mg)
price :
150 USD
more info or order :
citations: 6
Reference
Bigford G, Chaudhry N, Keane R, Holohean A. 5-Hydroxytryptamine 5HT2C receptors form a protein complex with N-methyl-D-aspartate GluN2A subunits and activate phosphorylation of Src protein to modulate motoneuronal depolarization. J Biol Chem. 2012;287:11049-59 pubmed publisher
Murray K, Stephens M, Rank M, D Amico J, Gorassini M, Bennett D. Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol. 2011;106:925-43 pubmed publisher
Murray K, Nakae A, Stephens M, Rank M, D Amico J, Harvey P, et al. Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. Nat Med. 2010;16:694-700 pubmed publisher
Yu H, Yamaguchi A. Endogenous serotonin acts on 5-HT2C-like receptors in key vocal areas of the brain stem to initiate vocalizations in Xenopus laevis. J Neurophysiol. 2010;103:648-58 pubmed publisher
Yu H, Yamaguchi A. 5-HT2C-like receptors in the brain of Xenopus laevis initiate sex-typical fictive vocalizations. J Neurophysiol. 2009;102:752-65 pubmed publisher
Kawahara Y, Grimberg A, Teegarden S, Mombereau C, Liu S, Bale T, et al. Dysregulated editing of serotonin 2C receptor mRNAs results in energy dissipation and loss of fat mass. J Neurosci. 2008;28:12834-44 pubmed publisher
product information
brand :
Tocris
master code :
0941
SKU :
0941/10
product name :
MK 212 hydrochloride
description :
5-HT2C agonist
target :
5-HT2C Receptor Agonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
99%
observed molecular weight :
235.12
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
5-HT receptor agonist; displays selectivity for 5-HT2C over 5-HT2A (IC50 values are 0.028 and 0.42 M for human 5-HT2C and 5-HT2A receptors expressed in HEK293 cells respectively).
catalog number base :
941
product keywords :
5-HT2C agonist Serotonin Receptors 5-HT2 MK212 hydrochloride 5-HT2C Receptors 0941,
extended description :
5-HT2C agonist
chemical name text :
6-Chloro-2-(1-piperazinyl)pyrazine hydrochloride
formula :
C 8 H 11 ClN 4 .HCl
formula text :
C8H11ClN4.HCl
cas num :
61655-58-1
2020 USD :
144
2021 USD :
150 USD
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK