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company name :
Tocris Bioscience
product type :
chemical
product name :
0940/100
catalog :
0940/100
quantity :
100 mg
price :
108 USD
more info or order :
citations: 33
Reference
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Gutzmann J, Lin L, Hoffman D. Functional Coupling of Cav2.3 and BK Potassium Channels Regulates Action Potential Repolarization and Short-Term Plasticity in the Mouse Hippocampus. Front Cell Neurosci. 2019;13:27 pubmed publisher
Fan L, Nehme R, Adam Y, Jung E, Wu H, Eggan K, et al. All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition. Nat Methods. 2018;15:823-831 pubmed publisher
Dong W, Radulović T, Goral R, Thomas C, Suarez Montesinos M, Guerrero Given D, et al. CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse. Cell Rep. 2018;24:284-293.e6 pubmed publisher
Chang J, Higley M. Potassium channels contribute to activity-dependent regulation of dendritic inhibition. Physiol Rep. 2018;6:e13747 pubmed publisher
Beas B, Wright B, Skirzewski M, Leng Y, Hyun J, Koita O, et al. The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism. Nat Neurosci. 2018;21:963-973 pubmed publisher
Zhang Y, Reynolds J, Cragg S. Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification, with Dopamine Modulation. Neuron. 2018;98:918-925.e3 pubmed publisher
Kiritoshi T, Neugebauer V. Pathway-Specific Alterations of Cortico-Amygdala Transmission in an Arthritis Pain Model. ACS Chem Neurosci. 2018;9:2252-2261 pubmed publisher
Collins D, Anastasiades P, Marlin J, Carter A. Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei. Neuron. 2018;98:366-379.e4 pubmed publisher
Li Y, Zeng J, Zhang J, Yue C, Zhong W, Liu Z, et al. Hypothalamic Circuits for Predation and Evasion. Neuron. 2018;97:911-924.e5 pubmed publisher
Zhao Z, Wang L, Gao W, Hu F, Zhang J, Ren Y, et al. A Central Catecholaminergic Circuit Controls Blood Glucose Levels during Stress. Neuron. 2017;95:138-152.e5 pubmed publisher
Dinamarca M, Guzzetti F, Karpova A, Lim D, Mitro N, Musardo S, et al. Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus. elife. 2016;5:e12430 pubmed publisher
Robinson S, Lee T, Christie D, Birch N. Tissue plasminogen activator inhibits NMDA-receptor-mediated increases in calcium levels in cultured hippocampal neurons. Front Cell Neurosci. 2015;9:404 pubmed publisher
Cramer S, Popa L, Carter R, Chen G, Ebner T. Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse. J Neurosci. 2015;35:5664-79 pubmed publisher
Saunders A, Granger A, Sabatini B. Corelease of acetylcholine and GABA from cholinergic forebrain neurons. elife. 2015;4: pubmed publisher
Curcio M, Salazar I, Inácio A, Duarte E, Canzoniero L, Duarte C. Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons. Cell Death Dis. 2015;6:e1645 pubmed publisher
Leal G, Afonso P, Duarte C. Neuronal activity induces synaptic delivery of hnRNP A2/B1 by a BDNF-dependent mechanism in cultured hippocampal neurons. PLoS ONE. 2014;9:e108175 pubmed publisher
Chanda S, Ang C, Davila J, Pak C, Mall M, Lee Q, et al. Generation of induced neuronal cells by the single reprogramming factor ASCL1. Stem Cell Reports. 2014;3:282-96 pubmed publisher
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image
image 1 :
Tocris Bioscience 0940/100 image 1
Cat.No. 0940 - 4-Aminopyridine C5H6N2 CAS No. 504-24-5
product information
master code :
940
SKU :
0940/100
product name :
4-Aminopyridine
unit size :
100 mg
description :
Non-selective KV channel blocker
target :
Voltage-gated Potassium Channel Blockers
category :
Small Molecules
purity :
99%
observed molecular weight :
94.12
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
4-Aminopyridine is a non-selective voltage-dependent K+-channel blocker (IC50 values are 170 and 230 M at KV1.1 and KV1.2 respectively). Caged 4-AP (Cat. No. 3557) is also available.
top caption :
Non-selective KV channel blocker
extended description :
Non-selective KV channel blocker
formula :
C5H6N2
formula text :
C5H6N2
cas num :
504-24-5
USD :
108 USD
product details :
Non-selective KV channel blocker
alt names :
4-AP
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK