Haloperidol hydrochloride | Tocris Bioscience 0931 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Haloperidol hydrochloride

catalog :

0931

quantity :

100 mg

price :

87 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Joshi R, Panicker M. Identifying the In Vivo Cellular Correlates of Antipsychotic Drugs. Eneuro. 2018;5: pubmed publisher
CanfrÃ¡n Duque A, Pastor O, Reina M, Lerma M, Cruz Jentoft A, LasunciÃ³n M, et al. Curcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In Vitro. PLoS ONE. 2015;10:e0141829 pubmed publisher
Mishra A, Mavlyutov T, Singh D, Biener G, Yang J, Oliver J, et al. The sigma-1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands. Biochem J. 2015;466:263-271 pubmed publisher
Czysz A, Schappi J, Rasenick M. Lateral diffusion of GÎ±s in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. Neuropsychopharmacology. 2015;40:766-73 pubmed publisher
Kim F, Schrock J, Spino C, Marino J, Pasternak G. Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression. Biochem Biophys Res Commun. 2012;426:177-82 pubmed publisher
Kurita M, Holloway T, García Bea A, Kozlenkov A, Friedman A, Moreno J, et al. HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nat Neurosci. 2012;15:1245-54 pubmed publisher
Watson C, Dogruel M, Mihoreanu L, Begley D, Weksler B, Couraud P, et al. The transport of nifurtimox, an anti-trypanosomal drug, in an in vitro model of the human blood-brain barrier: evidence for involvement of breast cancer resistance protein. Brain Res. 2012;1436:111-21 pubmed publisher
Oliver P, Davies K. Interaction between environmental and genetic factors modulates schizophrenic endophenotypes in the Snap-25 mouse mutant blind-drunk. Hum Mol Genet. 2009;18:4576-89 pubmed publisher
Balu D, Hoshaw B, Malberg J, Rosenzweig Lipson S, Schechter L, Lucki I. Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments. Brain Res. 2008;1211:37-43 pubmed publisher

product information

brand :

Tocris

master code :

0931

SKU :

0931/100

product name :

Haloperidol hydrochloride

description :

Dopamine antagonist; displays some D2 selectivity

target :

Non-selective Dopamine Receptor Antagonists

category :

Small Molecules

unit size :

100 mg

purity :

99%

observed molecular weight :

412.33

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Dopamine antagonist with selectivity for D2-like receptors (Ki values are 1.2, ~ 7, 2.3, ~ 80 and ~ 100 nM for D2, D3, D4, D1 and D5 receptors respectively). Subtype-selective NMDA antagonist. Identified as targeting human host proteins that interact with SARS-CoV-2.

catalog number base :

931

product keywords :

Antagonists partly D2-like selective High affinity ligands 1 sigma1 2 sigma2 antagonist Dopamine Non-Selective Receptors dopaminergic COVID-19 SARS-CoV-2 severe acute respiratory syndrome Non-selective Dopamine Sigma1 Receptors COVID-19 0931,

extended description :

Dopamine antagonist; displays some D2 selectivity

chemical name text :

4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone hydrochloride

formula :

C 21 H 23 ClFNO 2 .HCl

formula text :

C21H23ClFNO2.HCl

cas num :

1511-16-6

2020 USD :

2021 USD :

87 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage