0927/10 | Tocris Bioscience 0927/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

0927/10

catalog :

0927/10

quantity :

10 mg (also 50 mg)

price :

128 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Kant R, Pasi S, Surolia A. Auto-Reactive Th17-Cells Trigger Obsessive-Compulsive-Disorder Like Behavior in Mice With Experimental Autoimmune Encephalomyelitis. Front Immunol. 2018;9:2508 pubmed publisher
Zhang X, Gaudry Q. Functional integration of a serotonergic neuron in the Drosophila antennal lobe. elife. 2016;5: pubmed publisher
Hooper C, Delaney C, Streeter T, Yarboro M, Poole S, Brown N, et al. Selective serotonin reuptake inhibitor exposure constricts the mouse ductus arteriosus in utero. Am J Physiol Heart Circ Physiol. 2016;311:H572-81 pubmed publisher
Sallin P, Jazwinska A. Acute stress is detrimental to heart regeneration in zebrafish. Open Biol. 2016;6: pubmed publisher
Pai V, Lemire J, ParÃ© J, Lin G, Chen Y, Levin M. Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation. J Neurosci. 2015;35:4366-85 pubmed publisher
Silva B, Goles N, Varas R, Campusano J. Serotonin receptors expressed in Drosophila mushroom bodies differentially modulate larval locomotion. PLoS ONE. 2014;9:e89641 pubmed publisher
Stuart S, Butler P, MunafÃ² M, Nutt D, Robinson E. A translational rodent assay of affective biases in depression and antidepressant therapy. Neuropsychopharmacology. 2013;38:1625-35 pubmed publisher
Kurita M, Holloway T, García Bea A, Kozlenkov A, Friedman A, Moreno J, et al. HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nat Neurosci. 2012;15:1245-54 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Nozawa K, Kawabata Shoda E, Doihara H, Kojima R, Okada H, Mochizuki S, et al. TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells. Proc Natl Acad Sci U S A. 2009;106:3408-13 pubmed publisher
MacLean M, Deuchar G, Hicks M, Morecroft I, Shen S, Sheward J, et al. Overexpression of the 5-hydroxytryptamine transporter gene: effect on pulmonary hemodynamics and hypoxia-induced pulmonary hypertension. Circulation. 2004;109:2150-5 pubmed

product information

master code :

927

SKU :

0927/10

product name :

Fluoxetine hydrochloride

unit size :

10 mg (also 50 mg)

description :

5-HT reuptake inhibitor

target :

5-HT Transporter Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

345.78

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a Ki of 0.9 nmol/l and is between 150- and 900-fold selective over 5-HT1A, 5-HT2A, H1, 1, 2-adrenergic, and muscarinic receptors. Antidepressant. Induces differentiation of neuronal precursors, enhancing neuronal characteristics. Fluoxetine also inhibits assembly and activation of the NLRP3-ASC inflammasome and prevents degeneration of retinal pigmented epithelium (RPE) cells in an animal model of dry age-related macular degeneration (AMD).

top caption :

5-HT reuptake inhibitor

extended description :

5-HT reuptake inhibitor

chemical name text :

N-Methyl-3-[(4-trifluoromethyl)phenoxy]-3-phenylpropylamine hydrochloride

formula :

C17H18F3NO.HCl

formula text :

C17H18F3NO.HCl

cas num :

56296-78-7

USD :

128 USD

product details :

5-HT reuptake inhibitor

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage