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company name :
Tocris Bioscience
product type :
chemical
product name :
0925/10
catalog :
0925/10
quantity :
10 mg (also 50 mg)
price :
183 USD
more info or order :
citations: 60
Reference
Tse D, Privitera L, Norton A, Gobbo F, Spooner P, Takeuchi T, et al. Cell-type-specific optogenetic stimulation of the locus coeruleus induces slow-onset potentiation and enhances everyday memory in rats. Proc Natl Acad Sci U S A. 2023;120:e2307275120 pubmed publisher
Dorst M, Tokarska A, Zhou M, Lee K, Stagkourakis S, Broberger C, et al. Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner. Nat Commun. 2020;11:5113 pubmed publisher
Cai Y, Ford C. Dopamine Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of Dopamine and Glutamate. Cell Rep. 2018;25:3148-3157.e3 pubmed publisher
Dai W, Liu X, Bao Y, Yan B, Jiang N, Yu B, et al. Selective blockade of spinal D2DR by levo-corydalmine attenuates morphine tolerance via suppressing PI3K/Akt-MAPK signaling in a MOR-dependent manner. Exp Mol Med. 2018;50:148 pubmed publisher
Lee J, Nam J, Nam Y, Nam H, Yoon G, Ko E, et al. The small molecule CA140 inhibits the neuroinflammatory response in wild-type mice and a mouse model of AD. J Neuroinflammation. 2018;15:286 pubmed publisher
Zhang S, Yang J, Reinach P, Wang F, Zhang L, Fan M, et al. Dopamine Receptor Subtypes Mediate Opposing Effects on Form Deprivation Myopia in Pigmented Guinea Pigs. Invest Ophthalmol Vis Sci. 2018;59:4441-4448 pubmed publisher
Chen E, Lallai V, Sherafat Y, Grimes N, Pushkin A, Fowler J, et al. Altered Baseline and Nicotine-Mediated Behavioral and Cholinergic Profiles in ChAT-Cre Mouse Lines. J Neurosci. 2018;38:2177-2188 pubmed publisher
Guo F, Zhao J, Zhao D, Wang J, Wang X, Feng Z, et al. Dopamine D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice. Aging Cell. 2017;16:1323-1333 pubmed publisher
Scheggi S, Ferrari A, Pelliccia T, Devoto P, De Montis M, Gambarana C. Fasting biases ?-opioid receptors toward ?-arrestin2-dependent signaling in the accumbens shell. Neuroscience. 2017;352:19-29 pubmed publisher
Mamaligas A, Cai Y, Ford C. Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission. Sci Rep. 2016;6:37834 pubmed publisher
Kasahara R, Yamamoto N, Suzuki K, Sobue K. The ?1 receptor regulates accumulation of GM1 ganglioside-enriched autophagosomes in astrocytes. Neuroscience. 2017;340:176-187 pubmed publisher
Beckley J, Laguesse S, Phamluong K, Morisot N, Wegner S, Ron D. The First Alcohol Drink Triggers mTORC1-Dependent Synaptic Plasticity in Nucleus Accumbens Dopamine D1 Receptor Neurons. J Neurosci. 2016;36:701-13 pubmed publisher
Fritz M, Klawonn A, Nilsson A, Singh A, Zajdel J, Wilhelms D, et al. Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice. J Clin Invest. 2016;126:695-705 pubmed
Hao J, Sun N, Lei L, Li X, Yao B, Sun K, et al. L-Stepholidine rescues memory deficit and synaptic plasticity in models of Alzheimer's disease via activating dopamine D1 receptor/PKA signaling pathway. Cell Death Dis. 2015;6:e1965 pubmed publisher
Brzosko Z, Schultz W, Paulsen O. Retroactive modulation of spike timing-dependent plasticity by dopamine. elife. 2015;4: pubmed publisher
Montalbano A, Corradetti R, Mlinar B. Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons. PLoS ONE. 2015;10:e0140369 pubmed publisher
Lee K, Chirwa S. Blocking Dopaminergic Signaling Soon after Learning Impairs Memory Consolidation in Guinea Pigs. PLoS ONE. 2015;10:e0135578 pubmed publisher
Tozzi A, de Iure A, Tantucci M, Durante V, Quiroga Varela A, Giampà C, et al. Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system. Front Cell Neurosci. 2015;9:192 pubmed publisher
Li X, Rubio F, Zeric T, Bossert J, Kambhampati S, Cates H, et al. Incubation of methamphetamine craving is associated with selective increases in expression of Bdnf and trkb, glutamate receptors, and epigenetic enzymes in cue-activated fos-expressing dorsal striatal neurons. J Neurosci. 2015;35:8232-44 pubmed publisher
Rioult Pedotti M, Pekanovic A, Atiemo C, Marshall J, Luft A. Dopamine Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation. PLoS ONE. 2015;10:e0124986 pubmed publisher
Marchant N, Kaganovsky K. A critical role of nucleus accumbens dopamine D1-family receptors in renewal of alcohol seeking after punishment-imposed abstinence. Behav Neurosci. 2015;129:281-91 pubmed publisher
Kim J, Tillu D, Quinn T, Mejia G, Shy A, Asiedu M, et al. Spinal dopaminergic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism. J Neurosci. 2015;35:6307-17 pubmed publisher
Pezze M, Marshall H, Cassaday H. Dopaminergic modulation of appetitive trace conditioning: the role of D1 receptors in medial prefrontal cortex. Psychopharmacology (Berl). 2015;232:2669-80 pubmed publisher
Meunier C, Callebert J, Cancela J, Fossier P. Effect of dopaminergic D1 receptors on plasticity is dependent of serotoninergic 5-HT1A receptors in L5-pyramidal neurons of the prefrontal cortex. PLoS ONE. 2015;10:e0120286 pubmed publisher
Savalli G, Bashir Z, Warburton E. Regionally selective requirement for D1/D5 dopaminergic neurotransmission in the medial prefrontal cortex in object-in-place associative recognition memory. Learn Mem. 2015;22:69-73 pubmed publisher
Zhao Z, Kim Y, Wu Y, Zhang J, Lee J, Li X, et al. Korean Red Ginseng attenuates anxiety-like behavior during ethanol withdrawal in rats. J Ginseng Res. 2014;38:256-63 pubmed publisher
Conley J, Meyer J, Nuss A, Doyle T, Savinov S, Hill C, et al. Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti. J Pharmacol Exp Ther. 2015;352:53-60 pubmed publisher
Marcott P, Mamaligas A, Ford C. Phasic dopamine release drives rapid activation of striatal D2-receptors. Neuron. 2014;84:164-176 pubmed publisher
Fuenzalida J, Galaz P, Araya K, Slater P, Blanco E, Campusano J, et al. Dopamine D1 and corticotrophin-releasing hormone type-2? receptors assemble into functionally interacting complexes in living cells. Br J Pharmacol. 2014;171:5650-64 pubmed publisher
Lee K, Pellom S, Oliver E, Chirwa S. Characterization of the guinea pig animal model and subsequent comparison of the behavioral effects of selective dopaminergic drugs and methamphetamine. Synapse. 2014;68:221-33 pubmed publisher
Corcoran K, Leaderbrand K, Radulovic J. Extinction of remotely acquired fear depends on an inhibitory NR2B/PKA pathway in the retrosplenial cortex. J Neurosci. 2013;33:19492-8 pubmed publisher
Ribeiro F, Devries R, Hamilton A, Guimaraes I, Cregan S, Pires R, et al. Metabotropic glutamate receptor 5 knockout promotes motor and biochemical alterations in a mouse model of Huntington's disease. Hum Mol Genet. 2014;23:2030-42 pubmed publisher
Chen Y, Morganstern I, Barson J, Hoebel B, Leibowitz S. Differential role of D1 and D2 receptors in the perifornical lateral hypothalamus in controlling ethanol drinking and food intake: possible interaction with local orexin neurons. Alcohol Clin Exp Res. 2014;38:777-86 pubmed publisher
Jia J, Zhao J, Hu Z, Lindberg D, Li Z. Age-dependent regulation of synaptic connections by dopamine D2 receptors. Nat Neurosci. 2013;16:1627-36 pubmed publisher
Cilz N, Kurada L, Hu B, Lei S. Dopaminergic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K⁺, and T-type Ca²⁺ channels. Cereb Cortex. 2014;24:3195-208 pubmed publisher
Zhang C, Tallarida C, Raffa R, Rawls S. Sucrose produces withdrawal and dopamine-sensitive reinforcing effects in planarians. Physiol Behav. 2013;112-113:8-13 pubmed publisher
Huang C, Wu J, Liao R, Zhang W. SKF83959, an agonist of phosphatidylinositol-linked D(1)-like receptors, promotes ERK1/2 activation and cell migration in cultured rat astrocytes. PLoS ONE. 2012;7:e49954 pubmed publisher
Lisek R, Xu W, Yuvasheva E, Chiu Y, Reitz A, Liu Chen L, et al. Mephedrone ('bath salt') elicits conditioned place preference and dopamine-sensitive motor activation. Drug Alcohol Depend. 2012;126:257-62 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Prado C, Contreras F, Gonzalez H, Diaz P, Elgueta D, Barrientos M, et al. Stimulation of dopamine receptor D5 expressed on dendritic cells potentiates Th17-mediated immunity. J Immunol. 2012;188:3062-70 pubmed publisher
Shin E, Nguyen X, Nguyen T, Pham D, Kim H. Exposure to extremely low frequency magnetic fields induces fos-related antigen-immunoreactivity via activation of dopaminergic d1 receptor. Exp Neurobiol. 2011;20:130-6 pubmed publisher
Li C, Dabrowska J, Hazra R, Rainnie D. Synergistic activation of dopamine D1 and TrkB receptors mediate gain control of synaptic plasticity in the basolateral amygdala. PLoS ONE. 2011;6:e26065 pubmed publisher
Krishnan B, Genzer K, Pollandt S, Liu J, Gallagher J, Shinnick Gallagher P. Dopamine-induced plasticity, phospholipase D (PLD) activity and cocaine-cue behavior depend on PLD-linked metabotropic glutamate receptors in amygdala. PLoS ONE. 2011;6:e25639 pubmed publisher
Xu T, Ma Q, Spealman R, Yao W. Amphetamine modulation of long-term potentiation in the prefrontal cortex: dose dependency, monoaminergic contributions, and paradoxical rescue in hyperdopaminergic mutant. J Neurochem. 2010;115:1643-54 pubmed publisher
Raghuraman G, Prabhakar N, Kumar G. Post-translational modification of glutamic acid decarboxylase 67 by intermittent hypoxia: evidence for the involvement of dopamine D1 receptor signaling. J Neurochem. 2010;115:1568-78 pubmed publisher
Deng J, Rodriguiz R, Hutchinson A, Kim I, Wetsel W, West A. MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants. Nat Neurosci. 2010;13:1128-36 pubmed publisher
Nunes E, Randall P, Santerre J, Given A, Sager T, Correa M, et al. Differential effects of selective adenosine antagonists on the effort-related impairments induced by dopamine D1 and D2 antagonism. Neuroscience. 2010;170:268-80 pubmed publisher
Krishnan B, Centeno M, Pollandt S, Fu Y, Genzer K, Liu J, et al. Dopamine receptor mechanisms mediate corticotropin-releasing factor-induced long-term potentiation in the rat amygdala following cocaine withdrawal. Eur J Neurosci. 2010;31:1027-42 pubmed publisher
Schwendt M, McGinty J. Amphetamine up-regulates activator of G-protein signaling 1 mRNA and protein levels in rat frontal cortex: the role of dopamine and glucocorticoid receptors. Neuroscience. 2010;168:96-107 pubmed publisher
Goffin D, Ali A, Rampersaud N, Harkavyi A, Fuchs C, Whitton P, et al. Dopamine-dependent tuning of striatal inhibitory synaptogenesis. J Neurosci. 2010;30:2935-50 pubmed publisher
Xu T, Sotnikova T, Liang C, Zhang J, Jung J, Spealman R, et al. Hyperdopaminergic tone erodes prefrontal long-term potential via a D2 receptor-operated protein phosphatase gate. J Neurosci. 2009;29:14086-99 pubmed publisher
Chuhma N, Choi W, Mingote S, Rayport S. Dopamine neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection. Neuroscience. 2009;164:1068-83 pubmed publisher
Ma L, Liu C, Wang F, Xie N, Gu J, Fu H, et al. Activation of phosphatidylinositol-linked novel D1 dopamine receptors inhibits high-voltage-activated Ca2+ currents in primary cultured striatal neurons. J Neurophysiol. 2009;101:2230-8 pubmed publisher
Kash T, Nobis W, Matthews R, Winder D. Dopamine enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process. J Neurosci. 2008;28:13856-65 pubmed publisher
Costa C, Belcastro V, Tozzi A, Di Filippo M, Tantucci M, Siliquini S, et al. Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition. J Neurosci. 2008;28:8040-52 pubmed publisher
Rao Y, Liu Z, Borok E, Rabenstein R, Shanabrough M, Lu M, et al. Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons. J Clin Invest. 2007;117:4022-33 pubmed
Clancy S, Boyer S, Slesinger P. Coregulation of natively expressed pertussis toxin-sensitive muscarinic receptors with G-protein-activated potassium channels. J Neurosci. 2007;27:6388-99 pubmed
Witkovsky P, Svenningsson P, Yan L, Bateup H, Silver R. Cellular localization and function of DARPP-32 in the rodent retina. Eur J Neurosci. 2007;25:3233-42 pubmed
Nackley A, Tan K, Fecho K, Flood P, Diatchenko L, Maixner W. Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors. Pain. 2007;128:199-208 pubmed
Meredith E, Holder M, Rosén A, Lee A, Dyer M, Barnes N, et al. Dopamine targets cycling B cells independent of receptors/transporter for oxidative attack: Implications for non-Hodgkin's lymphoma. Proc Natl Acad Sci U S A. 2006;103:13485-90 pubmed
product information
master code :
925
SKU :
0925/10
product name :
SCH 23390 hydrochloride
unit size :
10 mg (also 50 mg)
description :
Selective D1-like antagonist; also 5-HT2C agonist and Kir3 channel blocker
target :
Dopamine D1 and D5 Receptor Antagonists
category :
Small Molecules
purity :
98%
observed molecular weight :
324.24
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
SCH 23390 hydrochloride is a potent dopamine receptor antagonist (Ki values are 0.2 nM and 0.3 nM at D1 and D5 receptor sub-types, respectively). Also an agonist at 5-HT2C receptors in vitro (Ki values are 6.3 - 9.3 nM). Blocks quinpirole-induced Kir3 (GIRK) currents (EC50 = 268 nM) independently of receptors.
top caption :
Selective D1-like antagonist; also 5-HT2C agonist and Kir3 channel blocker
extended description :
Selective D1-like antagonist; also 5-HT2C agonist and Kir3 channel blocker
chemical name text :
(R)-(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
formula :
C17H18ClNO.HCl
formula text :
C17H18ClNO.HCl
cas num :
125941-87-9
USD :
183 USD
product details :
Selective D1-like antagonist; also 5-HT2C agonist and Kir3 channel blocker
alt names :
( R )-(+)-SCH 23390 hydrochloride
storage :
Desiccate at +4░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK