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company name :
Tocris Bioscience
product type :
chemical
product name :
0924/10
catalog :
0924/10
quantity :
10 mg (also 50 mg)
price :
121 USD
more info or order :
citations: 98
Reference
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Sánchez Blázquez P, Rodríguez Muñoz M, Herrero Labrador R, Burgueno J, Zamanillo D, Garzón J. The calcium-sensitive Sigma-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases. Int J Neuropsychopharmacol. 2014;17:1943-55 pubmed publisher
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Klug J, Mathur B, Kash T, Wang H, Matthews R, Robison A, et al. Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability. PLoS ONE. 2012;7:e45323 pubmed publisher
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Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Laricchiuta D, Rossi S, Musella A, De Chiara V, Cutuli D, Centonze D, et al. Differences in spontaneously avoiding or approaching mice reflect differences in CB1-mediated signaling of dorsal striatal transmission. PLoS ONE. 2012;7:e33260 pubmed publisher
Jarzylo L, Man H. Parasynaptic NMDA receptor signaling couples neuronal glutamate transporter function to AMPA receptor synaptic distribution and stability. J Neurosci. 2012;32:2552-63 pubmed publisher
Roselli F, Livrea P, Almeida O. CDK5 is essential for soluble amyloid ?-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton. PLoS ONE. 2011;6:e23097 pubmed publisher
Rodríguez Muñoz M, Sánchez Blázquez P, Vicente Sánchez A, Berrocoso E, Garzón J. The mu-opioid receptor and the NMDA receptor associate in PAG neurons: implications in pain control. Neuropsychopharmacology. 2012;37:338-49 pubmed publisher
Lecrux C, Toussay X, Kocharyan A, Fernandes P, Neupane S, Levesque M, et al. Pyramidal neurons are "neurogenic hubs" in the neurovascular coupling response to whisker stimulation. J Neurosci. 2011;31:9836-47 pubmed publisher
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Chang C, Jiang X, Moulder K, Mennerick S. Rapid activation of dormant presynaptic terminals by phorbol esters. J Neurosci. 2010;30:10048-60 pubmed publisher
Leveille F, Papadia S, Fricker M, Bell K, Soriano F, Martel M, et al. Suppression of the intrinsic apoptosis pathway by synaptic activity. J Neurosci. 2010;30:2623-35 pubmed publisher
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Fallarini S, Miglio G, Paoletti T, Minassi A, Amoruso A, Bardelli C, et al. Clovamide and rosmarinic acid induce neuroprotective effects in in vitro models of neuronal death. Br J Pharmacol. 2009;157:1072-84 pubmed publisher
Gielen M, SIEGLER RETCHLESS B, Mony L, Johnson J, Paoletti P. Mechanism of differential control of NMDA receptor activity by NR2 subunits. Nature. 2009;459:703-7 pubmed publisher
Chao D, Balboni G, Lazarus L, Salvadori S, Xia Y. Na+ mechanism of delta-opioid receptor induced protection from anoxic K+ leakage in the cortex. Cell Mol Life Sci. 2009;66:1105-15 pubmed publisher
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Furness D, Dehnes Y, Akhtar A, Rossi D, Hamann M, Grutle N, et al. A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes: new insights into a neuronal role for excitatory amino acid transporter 2 (EAAT2). Neuroscience. 2008;157:80-94 pubmed publisher
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Iwasato T, Inan M, Kanki H, Erzurumlu R, Itohara S, Crair M. Cortical adenylyl cyclase 1 is required for thalamocortical synapse maturation and aspects of layer IV barrel development. J Neurosci. 2008;28:5931-43 pubmed publisher
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product information
master code :
924
SKU :
0924/10
product name :
(+)-MK 801 maleate
unit size :
10 mg (also 50 mg)
description :
Non-competitive NMDA antagonist; acts at ion channel site
target :
NMDA Receptor Antagonists
category :
Small Molecules
purity :
99%
observed molecular weight :
337.37
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
(+)-MK 801 maleate is a high affinity (Ki = 37.2 nM), selective and non-competitive NMDA receptor antagonist. (+)-MK 801 maleate acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca2+ flux. It is an effective anti-ischemic agent in several animal models. (+)-MK 801 maleate increases motor activity in rat models. (+)-MK 801 maleate inhibits proliferation and increases apoptosis in hippocampal neural stem cells (NSCs). (+)-MK 801 maleate induces schizophrenia-like symptoms in rodents. . (-)-enantiomer also available.
top caption :
Non-competitive NMDA antagonist; acts at ion channel site
extended description :
Non-competitive NMDA antagonist; acts at ion channel site
chemical name text :
(5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate
formula :
C16H15N.C4H4O4
formula text :
C16H15N.C4H4O4
cas num :
77086-22-7
USD :
121 USD
product details :
Non-competitive NMDA antagonist; acts at ion channel site
alt names :
Dizocilpine
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK