SR 141716A | Tocris Bioscience 0923 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SR 141716A

catalog :

0923

quantity :

10 mg (also 50 mg)

price :

116 USD

citations: 16

Reference
Jimenez Blasco D, Busquets Garcia A, Hébert Chatelain E, Serrat R, Vicente Gutiérrez C, Ioannidou C, et al. Glucose metabolism links astroglial mitochondria to cannabinoid effects. Nature. 2020;583:603-608 pubmed publisher
Cecconi S, Rossi G, Oddi S, Di Nisio V, Maccarrone M. Role of Major Endocannabinoid-Binding Receptors during Mouse Oocyte Maturation. Int J Mol Sci. 2019;20: pubmed publisher
Khan M, Sobocińska A, Brodaczewska K, Zielniok K, Gajewska M, Kieda C, et al. Involvement of the CB2 cannabinoid receptor in cell growth inhibition and G0/G1 cell cycle arrest via the cannabinoid agonist WIN 55,212-2 in renal cell carcinoma. BMC Cancer. 2018;18:583 pubmed publisher
Jiang B, Wang Y, Wang H, Song L, Huang C, Zhu Q, et al. Antidepressant-like effects of fenofibrate in mice via the hippocampal brain-derived neurotrophic factor signalling pathway. Br J Pharmacol. 2017;174:177-194 pubmed publisher
Hayase T. Putative Epigenetic Involvement of the Endocannabinoid System in Anxiety- and Depression-Related Behaviors Caused by Nicotine as a Stressor. PLoS ONE. 2016;11:e0158950 pubmed publisher
BRUIJNZEEL A, Qi X, Guzhva L, Wall S, Deng J, Gold M, et al. Behavioral Characterization of the Effects of Cannabis Smoke and Anandamide in Rats. PLoS ONE. 2016;11:e0153327 pubmed publisher
Klingerman C, Stipanovic M, Hajnal A, Lynch C. Acute Metabolic Effects of Olanzapine Depend on Dose and Injection Site. Dose Response. 2015;13:1559325815618915 pubmed publisher
Tang A, Alger B. Homer protein-metabotropic glutamate receptor binding regulates endocannabinoid signaling and affects hyperexcitability in a mouse model of fragile X syndrome. J Neurosci. 2015;35:3938-45 pubmed publisher
Mahmoud M, Olszewska T, Liu H, Shore D, Hurst D, Reggio P, et al. (4-(Bis(4-fluorophenyl)methyl)piperazin-1-yl)(cyclohexyl)methanone hydrochloride (LDK1229): a new cannabinoid CB1 receptor inverse agonist from the class of benzhydryl piperazine analogs. Mol Pharmacol. 2015;87:197-206 pubmed publisher
Marcu J, Shore D, Kapur A, Trznadel M, Makriyannis A, Reggio P, et al. Novel insights into CB1 cannabinoid receptor signaling: a key interaction identified between the extracellular-3 loop and transmembrane helix 2. J Pharmacol Exp Ther. 2013;345:189-97 pubmed publisher
Sumislawski J, Ramikie T, Patel S. Reversible gating of endocannabinoid plasticity in the amygdala by chronic stress: a potential role for monoacylglycerol lipase inhibition in the prevention of stress-induced behavioral adaptation. Neuropsychopharmacology. 2011;36:2750-61 pubmed publisher
Kapur A, Samaniego P, Thakur G, Makriyannis A, Abood M. Mapping the structural requirements in the CB1 cannabinoid receptor transmembrane helix II for signal transduction. J Pharmacol Exp Ther. 2008;325:341-8 pubmed publisher
Graham E, Ball N, Scotter E, Narayan P, Dragunow M, Glass M. Induction of Krox-24 by endogenous cannabinoid type 1 receptors in Neuro2A cells is mediated by the MEK-ERK MAPK pathway and is suppressed by the phosphatidylinositol 3-kinase pathway. J Biol Chem. 2006;281:29085-95 pubmed
Kettunen P, Kyriakatos A, Hallén K, El Manira A. Neuromodulation via conditional release of endocannabinoids in the spinal locomotor network. Neuron. 2005;45:95-104 pubmed
Stanford S, Gitlin J, Mitchell J. Identification of two distinct vasodilator pathways activated by ATP in the mesenteric bed of the rat. Br J Pharmacol. 2001;133:825-32 pubmed
Martin R, Luong L, Welsh N, Eglen R, Martin G, Maclennan S. Effects of cannabinoid receptor agonists on neuronally-evoked contractions of urinary bladder tissues isolated from rat, mouse, pig, dog, monkey and human. Br J Pharmacol. 2000;129:1707-15 pubmed

product information

brand :

Tocris

master code :

0923

SKU :

0923/10

product name :

SR 141716A

description :

Selective CB1 inverse agonist

target :

Cannabinoid R1 / CB1 Inverse Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

500.25

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective cannabinoid CB1 receptor antagonist (Ki = 1.98 nM). Also acts as an inverse agonist reversing adenylyl cyclase inhibition by WIN 55,212-2 (Cat.No. 1038) (IC50 = 48 nM). Displays no activity at CB2 receptors. Reduces food intake and body weight in orally dosed non-obese Wistar rats. Also -opioid receptor antagonist (Ki = 652 nm)

catalog number base :

923

product keywords :

SR141716A rimonabant cannabinoid cb1 selective potent orally available inverse agonists antagonists RIMO Rimonabant hydrochloride CB1 Receptors 0923,

extended description :

Selective CB1 inverse agonist

chemical name text :

N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride

formula :

C 22 H 21 Cl 3 N 4 O.HCl

formula text :

C22H21Cl3N4O.HCl

cas num :

158681-13-1

2020 USD :

111

2021 USD :

116 USD

alt names :

Rimonabant hydrochloride

storage :

Desiccate at RT