0915/10 | Tocris Bioscience 0915/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

0915/10

catalog :

0915/10

quantity :

10 mg (also 50 mg)

price :

219 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Merino B, Quesada I, HernÃ¡ndez Cascales J. Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol. PLoS ONE. 2015;10:e0132884 pubmed publisher
Ã˜rstavik Ã, Manfra O, Andressen K, Andersen G, Skomedal T, Osnes J, et al. The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium. PLoS ONE. 2015;10:e0115547 pubmed publisher
Hubert F, Belacel Ouari M, Manoury B, Zhai K, Domergue Dupont V, Mateo P, et al. Alteration of vascular reactivity in heart failure: role of phosphodiesterases 3 and 4. Br J Pharmacol. 2014;171:5361-75 pubmed publisher
Brunet S, Scheuer T, Catterall W. Increased intracellular magnesium attenuates β-adrenergic stimulation of the cardiac Ca(V)1.2 channel. J Gen Physiol. 2013;141:85-94 pubmed publisher
Zhai K, Hubert F, Nicolas V, Ji G, Fischmeister R, Leblais V. ?-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells. PLoS ONE. 2012;7:e47826 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher

product information

master code :

915

SKU :

0915/10

product name :

Cilostamide

unit size :

10 mg (also 50 mg)

description :

PDE3 inhibitor

target :

Phosphodiesterase Inhibitors

category :

Small Molecules

purity :

97%

observed molecular weight :

342.44

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Cilostamide is a selective inhibitor of type III phosphodiesterase (PDE3). Displays moderate selectivity for PDE3A isozyme vs. PDE3B (IC50 values are 0.027 and 0.050 u M for PDE3A and PDE3B respectively). Inhibits ADP-induced platelet aggregation (IC50 = 16.8 u M); antithrombotic.

top caption :

PDE3 inhibitor

extended description :

PDE3 inhibitor

chemical name text :

N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide

formula :

C20H26N2O3

formula text :

C20H26N2O3

cas num :

68550-75-4

USD :

219 USD

product details :

PDE3 inhibitor

alt names :

OCP 3689

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage