Glibenclamide | Tocris Bioscience 0911/100 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Glibenclamide

catalog :

0911/100

quantity :

100 mg

price :

96 USD

more info or order :

Tocris Bioscience product webpage

citations: 18

Reference
O Malley J, Seibt F, Chin J, Beierlein M. TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations. J Neurosci. 2020;40:4813-4823 pubmed publisher
Mehmood M, Munir S, Khalid U, Asrar M, Gilani A. Antidiarrhoeal, antisecretory and antispasmodic activities of Matricaria chamomilla are mediated predominantly through K(+)-channels activation. BMC Complement Altern Med. 2015;15:75 pubmed publisher
Fransen P, Van Hove C, Leloup A, Martinet W, De Meyer G, Lemmens K, et al. Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments. PLoS ONE. 2015;10:e0121634 pubmed publisher
Chen M, Tsai J, Chen L, Wu T, Yang J, Yin L, et al. Characterization of imidazoline receptors in blood vessels for the development of antihypertensive agents. Biomed Res Int. 2014;2014:182846 pubmed publisher
Jiang Y, Zsombok A. Regulation of neurons in the dorsal motor nucleus of the vagus by SIRT1. Front Neurosci. 2014;7:270 pubmed publisher
Seto S, Au A, Poon C, Zhang Q, Li R, Yeung J, et al. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. PLoS ONE. 2013;8:e66404 pubmed publisher
Wu M, Chen S, Yang A, Lin W, Lin Y, Chen N, et al. CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages. Blood. 2013;121:95-106 pubmed publisher
Xu L, Huang S. Effect of the ginsenoside Rb1 on the spontaneous contraction of intestinal smooth muscle in mice. World J Gastroenterol. 2012;18:5462-9 pubmed publisher
Parsons M, Burt J, Cranford A, Alberto C, Zipperlen K, Hirasawa M. Nociceptin induces hypophagia in the perifornical and lateral hypothalamic area. PLoS ONE. 2012;7:e45350 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Chung K, Freestone P, Lipski J. Expression and functional properties of TRPM2 channels in dopaminergic neurons of the substantia nigra of the rat. J Neurophysiol. 2011;106:2865-75 pubmed publisher
Lee Y, Chang H, Chiang C, Liu C, Yeh J, Chen M, et al. Role of perivascular adipose tissue-derived methyl palmitate in vascular tone regulation and pathogenesis of hypertension. Circulation. 2011;124:1160-71 pubmed publisher
Saloman J, Niu K, Ro J. Activation of peripheral delta-opioid receptors leads to anti-hyperalgesic responses in the masseter muscle of male and female rats. Neuroscience. 2011;190:379-85 pubmed publisher
Quock L, Zhang Y, Chung E, Ohgami Y, Shirachi D, Quock R. The acute antinociceptive effect of HBO₂ is mediated by a NO-cyclic GMP-PKG-KATP channel pathway in mice. Brain Res. 2011;1368:102-7 pubmed publisher
Parsons M, Hirasawa M. ATP-sensitive potassium channel-mediated lactate effect on orexin neurons: implications for brain energetics during arousal. J Neurosci. 2010;30:8061-70 pubmed publisher
He X, Mekasha S, Mavrogiorgos N, Fitzgerald K, Lien E, Ingalls R. Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome. J Immunol. 2010;184:5743-54 pubmed publisher
Song D, Jang Y, Kim J, Chun K, Lee D, Xu Z. Polyphenol (-)-epigallocatechin gallate during ischemia limits infarct size via mitochondrial K(ATP) channel activation in isolated rat hearts. J Korean Med Sci. 2010;25:380-6 pubmed publisher
Price C, Samson W, Ferguson A. Nesfatin-1 inhibits NPY neurons in the arcuate nucleus. Brain Res. 2008;1230:99-106 pubmed publisher

product information

brand :

Tocris

catalog number base :

911

SKU :

0911/100

product name :

Glibenclamide

units size :

100 mg

description :

Kir6 (KATP) channel blocker

target :

Inward Rectifier Potassium Channel Blockers

category :

Small Molecules

purity :

98%

observed molecular weight :

494

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

review stars :

details of functionality :

Glibenclamide is an ATP-dependent K+ channel (Kir6, KATP) and CFTR Cl- channel blocker. Inhibits Kir6 currents in the pancreas, by binding to the SUR1 regulatory subunit, causing an increase in intracellular Ca2+ and insulin secretion. Inhibits recombinant CFTR Cl- channels with an IC50 of 20 u M.

top caption :

Kir6 (KATP) channel blocker

extended description :

Kir6 (KATP) channel blocker

chemical name text :

5-Chloro-N-[2-[4-[[[(Cylcohexylamino)carbonyl]amino]sulphonyl]phenyl]ethyl]-2-methoxybenzamide

formula :

C23H28ClN3O5S

formula text :

C23H28ClN3O5S

cas num :

10238-21-8

USD :

96 USD

product details :

Kir6 (KATP) channel blocker

alt names :

Glyburide

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage