product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
0911/100
catalog :
0911/100
quantity :
100 mg
price :
96 USD
more info or order :
citations: 18
Reference
O Malley J, Seibt F, Chin J, Beierlein M. TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations. J Neurosci. 2020;40:4813-4823 pubmed publisher
Mehmood M, Munir S, Khalid U, Asrar M, Gilani A. Antidiarrhoeal, antisecretory and antispasmodic activities of Matricaria chamomilla are mediated predominantly through K(+)-channels activation. BMC Complement Altern Med. 2015;15:75 pubmed publisher
Fransen P, Van Hove C, Leloup A, Martinet W, De Meyer G, Lemmens K, et al. Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments. PLoS ONE. 2015;10:e0121634 pubmed publisher
Chen M, Tsai J, Chen L, Wu T, Yang J, Yin L, et al. Characterization of imidazoline receptors in blood vessels for the development of antihypertensive agents. Biomed Res Int. 2014;2014:182846 pubmed publisher
Jiang Y, Zsombok A. Regulation of neurons in the dorsal motor nucleus of the vagus by SIRT1. Front Neurosci. 2014;7:270 pubmed publisher
Seto S, Au A, Poon C, Zhang Q, Li R, Yeung J, et al. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. PLoS ONE. 2013;8:e66404 pubmed publisher
Wu M, Chen S, Yang A, Lin W, Lin Y, Chen N, et al. CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages. Blood. 2013;121:95-106 pubmed publisher
Xu L, Huang S. Effect of the ginsenoside Rb1 on the spontaneous contraction of intestinal smooth muscle in mice. World J Gastroenterol. 2012;18:5462-9 pubmed publisher
Parsons M, Burt J, Cranford A, Alberto C, Zipperlen K, Hirasawa M. Nociceptin induces hypophagia in the perifornical and lateral hypothalamic area. PLoS ONE. 2012;7:e45350 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Chung K, Freestone P, Lipski J. Expression and functional properties of TRPM2 channels in dopaminergic neurons of the substantia nigra of the rat. J Neurophysiol. 2011;106:2865-75 pubmed publisher
Lee Y, Chang H, Chiang C, Liu C, Yeh J, Chen M, et al. Role of perivascular adipose tissue-derived methyl palmitate in vascular tone regulation and pathogenesis of hypertension. Circulation. 2011;124:1160-71 pubmed publisher
Saloman J, Niu K, Ro J. Activation of peripheral delta-opioid receptors leads to anti-hyperalgesic responses in the masseter muscle of male and female rats. Neuroscience. 2011;190:379-85 pubmed publisher
Quock L, Zhang Y, Chung E, Ohgami Y, Shirachi D, Quock R. The acute antinociceptive effect of HBO₂ is mediated by a NO-cyclic GMP-PKG-KATP channel pathway in mice. Brain Res. 2011;1368:102-7 pubmed publisher
Parsons M, Hirasawa M. ATP-sensitive potassium channel-mediated lactate effect on orexin neurons: implications for brain energetics during arousal. J Neurosci. 2010;30:8061-70 pubmed publisher
He X, Mekasha S, Mavrogiorgos N, Fitzgerald K, Lien E, Ingalls R. Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome. J Immunol. 2010;184:5743-54 pubmed publisher
Song D, Jang Y, Kim J, Chun K, Lee D, Xu Z. Polyphenol (-)-epigallocatechin gallate during ischemia limits infarct size via mitochondrial K(ATP) channel activation in isolated rat hearts. J Korean Med Sci. 2010;25:380-6 pubmed publisher
Price C, Samson W, Ferguson A. Nesfatin-1 inhibits NPY neurons in the arcuate nucleus. Brain Res. 2008;1230:99-106 pubmed publisher
product information
master code :
911
SKU :
0911/100
product name :
Glibenclamide
unit size :
100 mg
description :
Kir6 (KATP) channel blocker
target :
Inward Rectifier Potassium Channel Blockers
category :
Small Molecules
purity :
99%
observed molecular weight :
494
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Glibenclamide is an ATP-dependent K+ channel (Kir6, KATP) and CFTR Cl- channel blocker. Inhibits Kir6 currents in the pancreas, by binding to the SUR1 regulatory subunit, causing an increase in intracellular Ca2+ and insulin secretion. Inhibits recombinant CFTR Cl- channels with an IC50 of 20 u M.
top caption :
Kir6 (KATP) channel blocker
extended description :
Kir6 (KATP) channel blocker
chemical name text :
5-Chloro-N-[2-[4-[[[(Cylcohexylamino)carbonyl]amino]sulphonyl]phenyl]ethyl]-2-methoxybenzamide
formula :
C23H28ClN3O5S
formula text :
C23H28ClN3O5S
cas num :
10238-21-8
USD :
96 USD
product details :
Kir6 (KATP) channel blocker
alt names :
Glyburide
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK