product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
0910/1
catalog :
0910/1
quantity :
1 mg
price :
211 USD
more info or order :
citations: 15
Reference
Wang K, Zheng Y, Yang Y, Wang J, Li B, Wei F, et al. Nociceptin Receptor Is Overexpressed in Non-small Cell Lung Cancer and Predicts Poor Prognosis. Front Oncol. 2019;9:235 pubmed publisher
Schmid C, Kennedy N, Ross N, Lovell K, Yue Z, Morgenweck J, et al. Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics. Cell. 2017;171:1165-1175.e13 pubmed publisher
Fox P, Hentges S. Differential Desensitization Observed at Multiple Effectors of Somatic μ-Opioid Receptors Underlies Sustained Agonist-Mediated Inhibition of Proopiomelanocortin Neuron Activity. J Neurosci. 2017;37:8667-8677 pubmed publisher
Wang P, Ho I, Lee C. Buprenorphine-elicited alteration of adenylate cyclase activity in human embryonic kidney 293 cells coexpressing κ-, μ-opioid and nociceptin receptors. J Cell Mol Med. 2015;19:2587-96 pubmed publisher
Farrag M, Laufenberg L, Steiner J, Weller G, Lang C, Ruiz Velasco V. Modulation of voltage-gated Ca2+ channels by G protein-coupled receptors in celiac-mesenteric ganglion neurons of septic rats. PLoS ONE. 2015;10:e0125566 pubmed publisher
McIlwrath S, Westlund K. Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats. World J Gastroenterol. 2015;21:836-53 pubmed publisher
Popiolek Barczyk K, Rojewska E, Jurga A, Makuch W, Zador F, Borsodi A, et al. Minocycline enhances the effectiveness of nociceptin/orphanin FQ during neuropathic pain. Biomed Res Int. 2014;2014:762930 pubmed publisher
Kelly E, Mundell S, Sava A, Roth A, Felici A, Maltby K, et al. The opioid receptor pharmacology of GSK1521498 compared to other ligands with differential effects on compulsive reward-related behaviours. Psychopharmacology (Berl). 2015;232:305-14 pubmed publisher
Kallupi M, Varodayan F, Oleata C, Correia D, Luu G, Roberto M. Nociceptin/orphanin FQ decreases glutamate transmission and blocks ethanol-induced effects in the central amygdala of naive and ethanol-dependent rats. Neuropsychopharmacology. 2014;39:1081-92 pubmed publisher
Miranda Morales R, Nizhnikov M, Waters D, Spear N. Participation of the nociceptin/orphanin FQ receptor in ethanol-mediated locomotor activation and ethanol intake in preweanling rats. Behav Brain Res. 2013;245:137-44 pubmed publisher
Lee C, Yan J, Chiang Y, Hung T, Wang H, Chiou L, et al. Differential pharmacological actions of methadone and buprenorphine in human embryonic kidney 293 cells coexpressing human ?-opioid and opioid receptor-like 1 receptors. Neurochem Res. 2011;36:2008-21 pubmed publisher
Kokkola T, Savinainen J, Mönkkönen K, Retamal M, Laitinen J. S-nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner. BMC Cell Biol. 2005;6:21 pubmed
Kuzmin A, Sandin J, Terenius L, Ogren S. Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors. Br J Pharmacol. 2004;141:132-40 pubmed
McLeod R, Parra L, Mutter J, Erickson C, Carey G, Tulshian D, et al. Nociceptin inhibits cough in the guinea-pig by activation of ORL(1) receptors. Br J Pharmacol. 2001;132:1175-8 pubmed
Werthwein S, Bauer U, Nakazi M, Kathmann M, Schlicker E. Further characterization of the ORL1 receptor-mediated inhibition of noradrenaline release in the mouse brain in vitro. Br J Pharmacol. 1999;127:300-8 pubmed
product information
master code :
910
SKU :
0910/1
product name :
Nociceptin
unit size :
1 mg
description :
Endogenous NOP agonist
target :
NOP Receptor Agonists
category :
Peptides
purity :
95%
observed molecular weight :
1809
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=peptides
details of functionality :
Nociceptin is an endogenous ligand for the NOP opioid receptor (pKi = 8.6). Has no significant activity at u , or opioid receptors (pKi 6).
top caption :
Endogenous NOP agonist
extended description :
Endogenous NOP agonist
formula :
C79H129N27O22
formula text :
C79H129N27O22
cas num :
170713-75-4
USD :
211 USD
product details :
Endogenous NOP agonist
alt names :
Orphanin FQ
storage :
Store at -20░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK