product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Ketanserin tartrate
catalog :
0908
quantity :
250 mg
price :
526 USD
more info or order :
citations: 22
Reference
Nguyen H, Cho D, Jang S, Han S, Park S. Potentiation of the glycine response by serotonin on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice. Korean J Physiol Pharmacol. 2019;23:271-279 pubmed publisher
Courtiol E, Wilson D, Shah R, Sullivan R, Teixeira C. Maternal Regulation of Pups' Cortical Activity: Role of Serotonergic Signaling. Eneuro. 2018;5: pubmed publisher
Medrihan L, Sagi Y, Inde Z, Krupa O, Daniels C, Peyrache A, et al. Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus. Neuron. 2017;95:564-576.e4 pubmed publisher
Hirono M, Nagao S, Yanagawa Y, Konishi S. Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells. Neuropharmacology. 2017;118:79-89 pubmed publisher
Fanarioti E, Mavrikaki M, Panagis G, Mitsacos A, Nomikos G, Giompres P. Behavioral and neurochemical changes in mesostriatal dopaminergic regions of the rat after chronic administration of the cannabinoid receptor agonist WIN55,212-2. Int J Neuropsychopharmacol. 2014;18: pubmed publisher
Jiang X, Shen H, Yu A. Potentiation of 5-methoxy-N,N-dimethyltryptamine-induced hyperthermia by harmaline and the involvement of activation of 5-HT1A and 5-HT2A receptors. Neuropharmacology. 2015;89:342-51 pubmed
Kasper J, Booth R, Peris J. Serotonin-2C receptor agonists decrease potassium-stimulated GABA release in the nucleus accumbens. Synapse. 2015;69:78-85 pubmed publisher
Kuo H, Lai Y, Wu J, Lee K, Chu C, Chen I, et al. A xanthine-derivative K(+)-channel opener protects against serotonin-induced cardiomyocyte hypertrophy via the modulation of protein kinases. Int J Biol Sci. 2013;10:64-72 pubmed publisher
Saxena S, Roselli F, Singh K, Leptien K, Julien J, Gros Louis F, et al. Neuroprotection through excitability and mTOR required in ALS motoneurons to delay disease and extend survival. Neuron. 2013;80:80-96 pubmed publisher
Morecroft I, White K, Caruso P, Nilsen M, Loughlin L, Alba R, et al. Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension. Mol Ther. 2012;20:1516-28 pubmed publisher
Ratner C, Ettrup A, Bueter M, Haahr M, Compan V, le Roux C, et al. Cerebral markers of the serotonergic system in rat models of obesity and after Roux-en-Y gastric bypass. Obesity (Silver Spring). 2012;20:2133-41 pubmed publisher
Wood W, Lovell P, Mello C, Perkel D. Serotonin, via HTR2 receptors, excites neurons in a cortical-like premotor nucleus necessary for song learning and production. J Neurosci. 2011;31:13808-15 pubmed publisher
Johnson O, Becnel J, Nichols C. Serotonin receptor activity is necessary for olfactory learning and memory in Drosophila melanogaster. Neuroscience. 2011;192:372-81 pubmed publisher
Kleinbongard P, Bose D, Baars T, Mohlenkamp S, Konorza T, Schöner S, et al. Vasoconstrictor potential of coronary aspirate from patients undergoing stenting of saphenous vein aortocoronary bypass grafts and its pharmacological attenuation. Circ Res. 2011;108:344-52 pubmed publisher
Morecroft I, Pang L, Baranowska M, Nilsen M, Loughlin L, Dempsie Y, et al. In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension. Cardiovasc Res. 2010;85:593-603 pubmed publisher
Huang C, Liang Y, Lee C, Wu M, Hsu K. Repeated cocaine administration decreases 5-HT(2A) receptor-mediated serotonergic enhancement of synaptic activity in rat medial prefrontal cortex. Neuropsychopharmacology. 2009;34:1979-92 pubmed publisher
Watakabe A, Komatsu Y, Sadakane O, Shimegi S, Takahata T, Higo N, et al. Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses. Cereb Cortex. 2009;19:1915-28 pubmed publisher
Mbaki Y, Ramage A. Investigation of the role of 5-HT2 receptor subtypes in the control of the bladder and the urethra in the anaesthetized female rat. Br J Pharmacol. 2008;155:343-56 pubmed publisher
Hampson L, Mackin P, Agius L. Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs. Diabetologia. 2007;50:1743-51 pubmed
Gonzalez Maeso J, Weisstaub N, Zhou M, Chan P, Ivic L, Ang R, et al. Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior. Neuron. 2007;53:439-52 pubmed
Marinelli S, Schnell S, Hack S, Christie M, Wessendorf M, Vaughan C. Serotonergic and nonserotonergic dorsal raphe neurons are pharmacologically and electrophysiologically heterogeneous. J Neurophysiol. 2004;92:3532-7 pubmed
Morecroft I, Heeley R, Prentice H, Kirk A, MacLean M. 5-hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor. Br J Pharmacol. 1999;128:730-4 pubmed
product information
brand :
Tocris
master code :
0908
SKU :
0908/250
product name :
Ketanserin tartrate
description :
Selective 5-HT2A antagonist. Also antagonist at 5-HT1D
target :
5-HT2A Receptor Antagonists
category :
Small Molecules
unit size :
250 mg
purity :
97%
observed molecular weight :
545.52
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Selective 5-HT2A serotonin receptor antagonist; can also be used to discriminate between 5-HT1D and 5-HT1B receptor subtypes.
catalog number base :
908
product keywords :
Selective 5-HT2A antagonist 5-HT1D Serotonin Receptors R41468 R 41 468 5-HT2A Receptors 0908,
extended description :
Selective 5-HT2A antagonist. Also antagonist at 5-HT1D
chemical name text :
3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4[1H,3H]-quinazolinedione tartrate
formula :
C 22 H 22 FN 3 O 3 .C 4 H 6 O 6
formula text :
C22H22FN3O3.C4H6O6
cas num :
83846-83-7
2020 USD :
505
2021 USD :
526 USD
alt names :
R 41 468
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK