product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Rolipram
catalog :
0905
quantity :
10 mg (also 50 mg)
price :
125 USD
more info or order :
citations: 20
Reference
Franchini L, Stanic J, Ponzoni L, Mellone M, Carrano N, Musardo S, et al. Linking NMDA Receptor Synaptic Retention to Synaptic Plasticity and Cognition. iScience. 2019;19:927-939 pubmed publisher
Russo I, Di Benedetto G, Kaganovich A, Ding J, Mercatelli D, Morari M, et al. Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4. J Neuroinflammation. 2018;15:297 pubmed publisher
Ikezu T, Chen C, Deleo A, Zeldich E, Fallin M, Kanaan N, et al. Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans. J Neuroimmune Pharmacol. 2018;13:254-264 pubmed publisher
Pecha S, Flenner F, Söhren K, Lorenz K, Eschenhagen T, Christ T. β 1 Adrenoceptor antagonistic effects of the supposedly selective β 2 adrenoceptor antagonist ICI 118,551 on the positive inotropic effect of adrenaline in murine hearts. Pharmacol Res Perspect. 2015;3:e00168 pubmed publisher
Polito M, Guiot E, Gangarossa G, Longueville S, Doulazmi M, Valjent E, et al. Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3). Eneuro. 2015;2: pubmed publisher
Lundegaard P, Anastasaki C, Grant N, Sillito R, Zich J, Zeng Z, et al. MEK Inhibitors Reverse cAMP-Mediated Anxiety in Zebrafish. Chem Biol. 2015;22:1335-46 pubmed publisher
Merino B, Quesada I, Hernández Cascales J. Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol. PLoS ONE. 2015;10:e0132884 pubmed publisher
Parnell E, Koschinski A, Zaccolo M, Cameron R, Baillie G, Baillie G, et al. Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells. Biochim Biophys Acta. 2015;1853:1749-58 pubmed publisher
Ørstavik Ã, Manfra O, Andressen K, Andersen G, Skomedal T, Osnes J, et al. The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium. PLoS ONE. 2015;10:e0115547 pubmed publisher
Zhu G, Liu Y, Wang Y, Bi X, Baudry M. Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways. J Neurosci. 2015;35:621-33 pubmed publisher
Choi C, Schoenfeld B, Weisz E, Bell A, Chambers D, Hinchey J, et al. PDE-4 inhibition rescues aberrant synaptic plasticity in Drosophila and mouse models of fragile X syndrome. J Neurosci. 2015;35:396-408 pubmed publisher
Townsend E, Emala C. Quercetin acutely relaxes airway smooth muscle and potentiates ?-agonist-induced relaxation via dual phosphodiesterase inhibition of PLC? and PDE4. Am J Physiol Lung Cell Mol Physiol. 2013;305:L396-403 pubmed publisher
Orru M, Guitart X, Karcz Kubicha M, Solinas M, Justinova Z, Barodia S, et al. Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans. Neuropharmacology. 2013;67:476-84 pubmed publisher
Zhong P, Wang W, Yu F, Nazari M, Liu X, Liu Q. Phosphodiesterase 4 inhibition impairs cocaine-induced inhibitory synaptic plasticity and conditioned place preference. Neuropsychopharmacology. 2012;37:2377-87 pubmed publisher
Adderley S, Joshi C, Martin D, Tulis D. Phosphodiesterases Regulate BAY 41-2272-Induced VASP Phosphorylation in Vascular Smooth Muscle Cells. Front Pharmacol. 2012;3:10 pubmed publisher
Morales Garcia J, Redondo M, Alonso Gil S, Gil C, Perez C, Martinez A, et al. Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease. PLoS ONE. 2011;6:e17240 pubmed publisher
Adderley S, Sridharan M, Bowles E, Stephenson A, Sprague R, Ellsworth M. Inhibition of ATP release from erythrocytes: a role for EPACs and PKC. Microcirculation. 2011;18:128-35 pubmed publisher
Schapitz I, Behrend B, Pechmann Y, Lappe Siefke C, Kneussel S, Wallace K, et al. Neuroligin 1 is dynamically exchanged at postsynaptic sites. J Neurosci. 2010;30:12733-44 pubmed publisher
Hosoi T, Koguchi Y, Sugikawa E, Chikada A, Ogawa K, Tsuda N, et al. Identification of a novel human eicosanoid receptor coupled to G(i/o). J Biol Chem. 2002;277:31459-65 pubmed
Haynes J. A(2A) adenosine receptor mediated potassium channel activation in rat epididymal smooth muscle. Br J Pharmacol. 2000;130:685-91 pubmed
product information
brand :
Tocris
master code :
0905
SKU :
0905/10
product name :
Rolipram
description :
PDE4 inhibitor
target :
Phosphodiesterase Inhibitors
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
275.35
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Selective inhibitor of cAMP phosphodiesterase (PDE4) (IC50 = 2.0 u M). Discriminates between two conformational states of PDE4 isoenzymes. . R-enantiomer and S-enantiomer also available.
catalog number base :
905
product keywords :
PDE4 inhibitors inhibits Phosphodiesterases Phosphodiesterases 0905,
extended description :
PDE4 inhibitor
chemical name text :
4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
formula :
C 16 H 21 NO 3
formula text :
C16H21NO3
cas num :
61413-54-5
2020 USD :
120
2021 USD :
125 USD
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK