SYM 2081 | Tocris Bioscience 0903 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SYM 2081

catalog :

0903

quantity :

10 mg (also 50 mg)

price :

214 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Vielma A, Agurto A, Valdes J, Palacios A, Schmachtenberg O. Nitric oxide modulates the temporal properties of the glutamate response in type 4 OFF bipolar cells. PLoS ONE. 2014;9:e114330 pubmed publisher
Yoshii A, Zhao J, Pandian S, van Zundert B, Constantine Paton M. A Myosin Va mutant mouse with disruptions in glutamate synaptic development and mature plasticity in visual cortex. J Neurosci. 2013;33:8472-82 pubmed publisher
Rojas A, Wetherington J, Shaw R, Serrano G, Swanger S, Dingledine R. Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors. Mol Pharmacol. 2013;83:106-21 pubmed publisher
Gangadharan V, Wang R, UlzhÃ¶fer B, Luo C, Bardoni R, Bali K, et al. Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice. J Clin Invest. 2011;121:1608-23 pubmed publisher
Santos S, Luz L, Szucs P, Lima D, Derkach V, Safronov B. Transmission efficacy and plasticity in glutamatergic synapses formed by excitatory interneurons of the substantia gelatinosa in the rat spinal cord. PLoS ONE. 2009;4:e8047 pubmed publisher

product information

brand :

Tocris

master code :

0903

SKU :

0903/10

product name :

SYM 2081

description :

Highly selective kainate agonist

target :

Kainate Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

97%

observed molecular weight :

161.16

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and highly selective kainate receptor agonist, with an IC50 for inhibition of [3H]-kainate binding of 35 nM and almost 3,000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively. Also selectively inhibits the cloned excitatory amino acid transporter EAAT2 at higher concentrations.

catalog number base :

903

product keywords :

inhibitors inhibits EAAT2 kainate receptors agonist selective EAAT Excitatory Amino Acid Transporters GLT-1 Glutamate Monoamine Neurotransmitter iGluR Ionotropic SYM2081 Glutamate Transporters Kainate Receptors 0903,

extended description :

Highly selective kainate agonist

chemical name text :

(2S,4R)-4-Methylglutamic acid

formula :

C 6 H 11 NO 4

formula text :

C6H11NO4

cas num :

31137-74-3

2020 USD :

207

2021 USD :

214 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage