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company name :
Tocris Bioscience
product type :
chemical
product name :
0900/10
catalog :
0900/10
quantity :
10 mg (also 50 mg)
price :
314 USD
more info or order :
citations: 37
Reference
Kleiner J, Hollborn M, Wiedemann P, Bringmann A. Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells. Mol Vis. 2018;24:647-666 pubmed
Ng P, McIntosh K, Hargrave G, Ho K, Paul A, Plevin R. Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells. Cell Signal. 2018;51:59-71 pubmed publisher
Makkawi M, Howells D, Wright M, Jackson D. A complementary role for tetraspanin superfamily member TSSC6 and ADP purinergic P2Y12 receptor in platelets. Thromb Res. 2018;161:12-21 pubmed publisher
Barría I, Güiza J, Cifuentes F, Zamorano P, Saez J, Gonzalez J, et al. Trypanosoma cruzi Infection Induces Pannexin-1 Channel Opening in Cardiac Myocytes. Am J Trop Med Hyg. 2018;98:105-112 pubmed publisher
Kawano A, Kadomatsu R, Ono M, Kojima S, Tsukimoto M, Sakamoto H. Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors. PLoS ONE. 2015;10:e0127919 pubmed publisher
Riquelme M, Cea L, Vega J, Puebla C, Vargas A, Shoji K, et al. Pannexin channels mediate the acquisition of myogenic commitment in C2C12 reserve cells promoted by P2 receptor activation. Front Cell Dev Biol. 2015;3:25 pubmed publisher
Liñán Rico A, Wunderlich J, Enneking J, Tso D, Grants I, Williams K, et al. Neuropharmacology of purinergic receptors in human submucous plexus: Involvement of P2X₁, P2X₂, P2X₃ channels, P2Y and A₃ metabotropic receptors in neurotransmission. Neuropharmacology. 2015;95:83-99 pubmed publisher
Wang W, Luo J, Xiang F, Liu X, Jiang M, Liao L, et al. Nucleolin down-regulation is involved in ADP-induced cell cycle arrest in S phase and cell apoptosis in vascular endothelial cells. PLoS ONE. 2014;9:e110101 pubmed publisher
Giachini F, Leite R, Osmond D, Lima V, Inscho E, Webb R, et al. Anti-platelet therapy with clopidogrel prevents endothelial dysfunction and vascular remodeling in aortas from hypertensive rats. PLoS ONE. 2014;9:e91890 pubmed publisher
Tang F, Lane S, Korsak A, Paton J, Gourine A, Kasparov S, et al. Lactate-mediated glia-neuronal signalling in the mammalian brain. Nat Commun. 2014;5:3284 pubmed publisher
Li R, Diamond S. Detection of platelet sensitivity to inhibitors of COX-1, P2Y₁, and P2Y₁₂ using a whole blood microfluidic flow assay. Thromb Res. 2014;133:203-10 pubmed publisher
Alsaqati M, Chan S, Ralevic V. Investigation of the functional expression of purine and pyrimidine receptors in porcine isolated pancreatic arteries. Purinergic Signal. 2014;10:241-9 pubmed publisher
Pinheiro A, Paramos de Carvalho D, Certal M, Costa C, Magalhães Cardoso M, Ferreirinha F, et al. Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation. Cell Commun Signal. 2013;11:70 pubmed publisher
Ashpole N, Chawla A, Martin M, Brustovetsky T, Brustovetsky N, Hudmon A. Loss of calcium/calmodulin-dependent protein kinase II activity in cortical astrocytes decreases glutamate uptake and induces neurotoxic release of ATP. J Biol Chem. 2013;288:14599-611 pubmed publisher
Oestreich J, Ferraris S, Steinhubl S, Akers W. Pharmacodynamic interplay of the P2Y(1), P2Y(12), and TxA(2) pathways in platelets: the potential of triple antiplatelet therapy with P2Y(1) receptor antagonism. Thromb Res. 2013;131:e64-70 pubmed publisher
Alefishat E, Alexander S, Ralevic V. Antagonism of P2Y1-induced vasorelaxation by acyl CoA: a critical role for palmitate and 3'-phosphate. Br J Pharmacol. 2013;168:1911-22 pubmed publisher
Fei G, Fang X, Wang G, Liu S, Wang X, Xia Y, et al. Neurogenic mucosal bicarbonate secretion in guinea pig duodenum. Br J Pharmacol. 2013;168:880-90 pubmed publisher
Balduini A, Di Buduo C, Malara A, Lecchi A, Rebuzzini P, Currao M, et al. Constitutively released adenosine diphosphate regulates proplatelet formation by human megakaryocytes. Haematologica. 2012;97:1657-65 pubmed publisher
Flamm M, Colace T, Chatterjee M, Jing H, Zhou S, Jaeger D, et al. Multiscale prediction of patient-specific platelet function under flow. Blood. 2012;120:190-8 pubmed publisher
Hazleton J, Berman J, Eugenin E. Purinergic receptors are required for HIV-1 infection of primary human macrophages. J Immunol. 2012;188:4488-95 pubmed publisher
Gulbransen B, Bashashati M, Hirota S, Gui X, Roberts J, MacDonald J, et al. Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis. Nat Med. 2012;18:600-4 pubmed publisher
Schaff M, Receveur N, Bourdon C, Ohlmann P, Lanza F, Gachet C, et al. ?-arrestin-1 participates in thrombosis and regulates integrin aIIb?3 signalling without affecting P2Y receptors desensitisation and function. Thromb Haemost. 2012;107:735-48 pubmed publisher
del Puerto A, Díaz Hernández J, Tapia M, Gomez Villafuertes R, Benitez M, Zhang J, et al. Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation. J Cell Sci. 2012;125:176-88 pubmed publisher
Begum G, Kintner D, Liu Y, Cramer S, Sun D. DHA inhibits ER Ca2+ release and ER stress in astrocytes following in vitro ischemia. J Neurochem. 2012;120:622-30 pubmed publisher
Duffy A, Cobine C, Keef K. Changes in neuromuscular transmission in the W/W(v) mouse internal anal sphincter. Neurogastroenterol Motil. 2012;24:e41-55 pubmed publisher
Tran E, Sun H, Fang Y. Dynamic mass redistribution assays decode surface influence on signaling of endogenous purinergic P2Y receptors. Assay Drug Dev Technol. 2012;10:37-45 pubmed publisher
Martín Gil A, de Lara M, Crooke A, Santano C, Peral A, Pintor J. Silencing of P2Y(2) receptors reduces intraocular pressure in New Zealand rabbits. Br J Pharmacol. 2012;165:1163-72 pubmed publisher
Chandaka G, Salzer I, Drobny H, Boehm S, Schicker K. Facilitation of transmitter release from rat sympathetic neurons via presynaptic P2Y(1) receptors. Br J Pharmacol. 2011;164:1522-33 pubmed publisher
Kuboyama K, Harada H, Tozaki Saitoh H, Tsuda M, Ushijima K, Inoue K. Astrocytic P2Y(1) receptor is involved in the regulation of cytokine/chemokine transcription and cerebral damage in a rat model of cerebral ischemia. J Cereb Blood Flow Metab. 2011;31:1930-41 pubmed publisher
Hwang S, Durnin L, Dwyer L, Rhee P, Ward S, Koh S, et al. ?-nicotinamide adenine dinucleotide is an enteric inhibitory neurotransmitter in human and nonhuman primate colons. Gastroenterology. 2011;140:608-617.e6 pubmed publisher
Huang Y, Dando R, Roper S. Autocrine and paracrine roles for ATP and serotonin in mouse taste buds. J Neurosci. 2009;29:13909-18 pubmed publisher
Li G, Olson J. Purinergic activation of anion conductance and osmolyte efflux in cultured rat hippocampal neurons. Am J Physiol Cell Physiol. 2008;295:C1550-60 pubmed publisher
Gallego D, Gil V, Aleu J, Aulí M, Clave P, Jiménez M. Purinergic and nitrergic junction potential in the human colon. Am J Physiol Gastrointest Liver Physiol. 2008;295:G522-33 pubmed publisher
Braun O, Amisten S, Wihlborg A, Hunting K, Nilsson D, Erlinge D. Residual platelet ADP reactivity after clopidogrel treatment is dependent on activation of both the unblocked P2Y(1) and the P2Y (12) receptor and is correlated with protein expression of P2Y (12). Purinergic Signal. 2007;3:195-201 pubmed publisher
Mutafova Yambolieva V, Hwang S, Hao X, Chen H, Zhu M, Wood J, et al. Beta-nicotinamide adenine dinucleotide is an inhibitory neurotransmitter in visceral smooth muscle. Proc Natl Acad Sci U S A. 2007;104:16359-64 pubmed
Holinstat M, Voss B, Bilodeau M, McLaughlin J, Cleator J, Hamm H. PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation. J Biol Chem. 2006;281:26665-74 pubmed
Czajkowski R, Banachewicz W, Ilnytska O, Drobot L, Baranska J. Differential effects of P2Y1 and P2Y12 nucleotide receptors on ERK1/ERK2 and phosphatidylinositol 3-kinase signalling and cell proliferation in serum-deprived and nonstarved glioma C6 cells. Br J Pharmacol. 2004;141:497-507 pubmed
product information
master code :
900
SKU :
0900/10
product name :
MRS 2179 tetrasodium salt
unit size :
10 mg (also 50 mg)
description :
Selective P2Y1 antagonist
target :
P2Y Receptor Antagonists
category :
Small Molecules
purity :
98%
observed molecular weight :
513.16
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
MRS 2179 tetrasodium salt is a competitive antagonist at P2Y1 receptors (KB = 100 nM). Selective over P2X1 (IC50 = 1.15 u M), P2X3 (IC50 = 12.9 u M), P2X2, P2X4, P2Y2, P2Y4 and P2Y6 receptors. Inhibits the upregulation of NTPDase1 by ATP S.
top caption :
Selective P2Y1 antagonist
extended description :
Selective P2Y1 antagonist
chemical name text :
2 -Deoxy-N6-methyladenosine 3 ,5 -bisphosphate tetrasodium salt
formula :
C11H13N5O9P2Na4
formula text :
C11H13N5O9P2Na4
cas num :
1454889-37-2
USD :
314 USD
product details :
Selective P2Y1 antagonist
storage :
Store at -20░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK