product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
0895/100
catalog :
0895/100
quantity :
100 mg
price :
111 USD
more info or order :
citations: 22
Reference
Pedersen M, Pham J, Mancebo H, Inoue A, Asher W, Javitch J. A novel luminescence-based-β-arrestin recruitment assay for unmodified receptors. J Biol Chem. 2021;:100503 pubmed publisher
Dorst M, Tokarska A, Zhou M, Lee K, Stagkourakis S, Broberger C, et al. Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner. Nat Commun. 2020;11:5113 pubmed publisher
Dai W, Liu X, Bao Y, Yan B, Jiang N, Yu B, et al. Selective blockade of spinal D2DR by levo-corydalmine attenuates morphine tolerance via suppressing PI3K/Akt-MAPK signaling in a MOR-dependent manner. Exp Mol Med. 2018;50:148 pubmed publisher
Beas B, Wright B, Skirzewski M, Leng Y, Hyun J, Koita O, et al. The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism. Nat Neurosci. 2018;21:963-973 pubmed publisher
Jensen R. Effects of Dopamine D2-Like Receptor Antagonists on Light Responses of Ganglion Cells in Wild-Type and P23H Rat Retinas. PLoS ONE. 2015;10:e0146154 pubmed publisher
Brzosko Z, Schultz W, Paulsen O. Retroactive modulation of spike timing-dependent plasticity by dopamine. elife. 2015;4: pubmed publisher
Shin J, Adrover M, Wess J, Alvarez V. Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens. Proc Natl Acad Sci U S A. 2015;112:8124-9 pubmed publisher
Kim J, Tillu D, Quinn T, Mejia G, Shy A, Asiedu M, et al. Spinal dopaminergic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism. J Neurosci. 2015;35:6307-17 pubmed publisher
Ma G, Raivio N, Sabrià J, Ortiz J. Agonist and antagonist effects of aripiprazole on D₂-like receptors controlling rat brain dopamine synthesis depend on the dopaminergic tone. Int J Neuropsychopharmacol. 2014;18: pubmed publisher
Marcott P, Mamaligas A, Ford C. Phasic dopamine release drives rapid activation of striatal D2-receptors. Neuron. 2014;84:164-176 pubmed publisher
Lim G, Kim H, McCabe M, Chou C, Wang S, Chen L, et al. A leptin-mediated central mechanism in analgesia-enhanced opioid reward in rats. J Neurosci. 2014;34:9779-88 pubmed publisher
Dragicevic E, Poetschke C, Duda J, Schlaudraff F, Lammel S, Schiemann J, et al. Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons. Brain. 2014;137:2287-302 pubmed publisher
Baca M, Allan A, Partridge L, Wilson M. Gene-environment interactions affect long-term depression (LTD) through changes in dopamine receptor affinity in Snap25 deficient mice. Brain Res. 2013;1532:85-98 pubmed publisher
Cilz N, Kurada L, Hu B, Lei S. Dopaminergic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K⁺, and T-type Ca²⁺ channels. Cereb Cortex. 2014;24:3195-208 pubmed publisher
Ishima T, Iyo M, Hashimoto K. Neurite outgrowth mediated by the heat shock protein Hsp90?: a novel target for the antipsychotic drug aripiprazole. Transl Psychiatry. 2012;2:e170 pubmed publisher
Kurita M, Holloway T, García Bea A, Kozlenkov A, Friedman A, Moreno J, et al. HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nat Neurosci. 2012;15:1245-54 pubmed publisher
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product information
master code :
895
SKU :
0895/100
product name :
(S)-(-)-Sulpiride
unit size :
100 mg
description :
Standard selective D2-like antagonist
target :
Non-selective Dopamine Receptor Antagonists
category :
Small Molecules
purity :
99%
observed molecular weight :
341.42
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
( S )-(-)-Sulpiride is an active enantiomer. Selective D2-like dopamine antagonist (Ki values are ~ 0.015, ~ 0.013, 1, ~ 45 and ~ 77 u M at D2, D3, D4, D1 and D5 receptors respectively). . Racemate also available.
top caption :
Standard selective D2-like antagonist
extended description :
Standard selective D2-like antagonist
chemical name text :
(S)-(-)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide
formula :
C15H23N3O4S
formula text :
C15H23N3O4S
cas num :
23672-07-3
USD :
111 USD
product details :
Standard selective D2-like antagonist
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK