Amiloride hydrochloride | Tocris Bioscience 0890 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Amiloride hydrochloride

catalog :

0890

quantity :

100 mg

price :

63 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Neubert P, Homann A, Wendelborn D, Bär A, Krampert L, Trum M, et al. NCX1 represents an ionic Na+ sensing mechanism in macrophages. PLoS Biol. 2020;18:e3000722 pubmed publisher
Messerschmidt L, Fischer S, Wiedemann P, Bringmann A, Hollborn M. Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation. Mol Vis. 2019;25:329-344 pubmed
Roebber J, Roper S, Chaudhari N. The role of the anion in salt (NaCl) detection by mouse taste buds. J Neurosci. 2019;: pubmed publisher
Poon A, Inkol J, Luu A, Mutsaers A. Effects of the potassium-sparing diuretic amiloride on chemotherapy response in canine osteosarcoma cells. J Vet Intern Med. 2019;33:800-811 pubmed publisher
Barbaro N, Foss J, Kryshtal D, Tsyba N, Kumaresan S, Xiao L, et al. Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension. Cell Rep. 2017;21:1009-1020 pubmed publisher
Korang Yeboah M, Gorantla Y, Paulos S, Sharma P, Chaudhary J, PALANIAPPAN R. Polycaprolactone/maltodextrin nanocarrier for intracellular drug delivery: formulation, uptake mechanism, internalization kinetics, and subcellular localization. Int J Nanomedicine. 2015;10:4763-81 pubmed publisher
Jeong S, Lee S, Kim Y, Yoon M. Antinociceptive effects of amiloride and benzamil in neuropathic pain model rats. J Korean Med Sci. 2013;28:1238-43 pubmed publisher

product information

brand :

Tocris

master code :

0890

SKU :

0890/100

product name :

Amiloride hydrochloride

description :

Na+ channel blocker; also I2 imidazoline ligand

target :

Voltage-gated Sodium Channel Blockers

category :

Small Molecules

unit size :

100 mg

purity :

98%

observed molecular weight :

266.09

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Na+ channel blocker. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.

catalog number base :

890

product keywords :

I2 selective ligands differentiates I2A I2B Na+ channel blockers Imidazoline Receptors Sodium NaV Channels voltage-gated voltage-dependent NHE Na+ H+ exchanger ASIC upa urokinase-type plasminogen inhibitors inhibits I2 Receptors Voltage-gated Sodium Channels Na+/H+ Exchanger TRPP ASIC Urokinase 0890,

extended description :

Na+ channel blocker; also I2 imidazoline ligand

chemical name text :

3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide hydrochloride

formula :

C 6 H 8 ClN 7 O.HCl

formula text :

C6H8ClN7O.HCl

cas num :

2016-88-8

2020 USD :

2021 USD :

63 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage