0884/5 | Tocris Bioscience 0884/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

0884/5

catalog :

0884/5

quantity :

5 mg (also 25 mg)

price :

222 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Hedlund E, Belnoue L, Theofilopoulos S, Salto C, Bye C, Parish C, et al. Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors. Sci Rep. 2016;6:26448 pubmed publisher
Parker M, Vander Kooi C. Microplate-based screening for small molecule inhibitors of neuropilin-2/vascular endothelial growth factor-C interactions. Anal Biochem. 2014;453:4-6 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Urizar E, Yano H, Kolster R, Gales C, Lambert N, Javitch J. CODA-RET reveals functional selectivity as a result of GPCR heteromerization. Nat Chem Biol. 2011;7:624-30 pubmed publisher
Smith W, Starck S, Roberts R, Schuman E. Dopaminergic stimulation of local protein synthesis enhances surface expression of GluR1 and synaptic transmission in hippocampal neurons. Neuron. 2005;45:765-79 pubmed
Gorelova N, Seamans J, Yang C. Mechanisms of dopamine activation of fast-spiking interneurons that exert inhibition in rat prefrontal cortex. J Neurophysiol. 2002;88:3150-66 pubmed

product information

master code :

884

SKU :

0884/5

product name :

Dihydrexidine hydrochloride

unit size :

5 mg (also 25 mg)

description :

Selective D1-like agonist

target :

Dopamine D1 and D5 Receptor Agonists

category :

Small Molecules

purity :

98%

observed molecular weight :

303.79

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Dihydrexidine hydrochloride is an a potent, full efficacy dopamine D1 agonist which shows no agonist activity at peripheral D2 receptors or adrenoceptors at doses which cause maximal stimulation of D1 sites. The compound appears to be fully bioavailable in brain and exhibits profound antiparkinsonism effects in vivo .

top caption :

Selective D1-like agonist

extended description :

Selective D1-like agonist

chemical name text :

( )-trans-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine hydrochloride

formula :

C17H17NO2.HCl

formula text :

C17H17NO2.HCl

cas num :

137417-08-4

USD :

222 USD

product details :

Selective D1-like agonist

storage :

Desiccate at +4░C

more info or order :

Tocris Bioscience product webpage