product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
0883/10
catalog :
0883/10
quantity :
10 mg (also 50 mg)
price :
189 USD
more info or order :
citations: 19
Reference
Cortés Montero E, Rodríguez Muñoz M, Sánchez Blázquez P, Garzón J. The axonal motor neuropathy-related HINT1 protein is a zinc- and calmodulin-regulated cysteine SUMO protease. Antioxid Redox Signal. 2019;: pubmed publisher
Rodríguez Muñoz M, Onetti Y, Cortés Montero E, Garzón J, Sánchez Blázquez P. Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor. Mol Brain. 2018;11:51 pubmed publisher
Sánchez Blázquez P, Cortés Montero E, Rodríguez Muñoz M, Garzón J. Sigma 1 Receptor Antagonists Inhibit Manic-Like Behaviors in Two Congenital Strains of Mice. Int J Neuropsychopharmacol. 2018;21:938-948 pubmed publisher
Sánchez Blázquez P, Pozo Rodrigálvarez A, Merlos M, Garzón J. The Sigma-1 Receptor Antagonist, S1RA, Reduces Stroke Damage, Ameliorates Post-Stroke Neurological Deficits and Suppresses the Overexpression of MMP-9. Mol Neurobiol. 2018;55:4940-4951 pubmed publisher
Rodríguez Muñoz M, Cortés Montero E, Pozo Rodrigálvarez A, Sánchez Blázquez P, Garzón Niño J. The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders. Oncotarget. 2015;6:35458-77 pubmed publisher
Pabba M, Wong A, Ahlskog N, Hristova E, Biscaro D, Nassrallah W, et al. NMDA receptors are upregulated and trafficked to the plasma membrane after sigma-1 receptor activation in the rat hippocampus. J Neurosci. 2014;34:11325-38 pubmed publisher
Smith C, Martin S, Sugunan K, Russek S, Gibbs T, Farb D. A role for picomolar concentrations of pregnenolone sulfate in synaptic activity-dependent Ca2+ signaling and CREB activation. Mol Pharmacol. 2014;86:390-8 pubmed publisher
Pan B, Guo Y, Kwok W, Hogan Q, Wu H. Sigma-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons. J Pharmacol Exp Ther. 2014;350:290-300 pubmed publisher
Zhao J, Ha Y, Liou G, Gonsalvez G, Smith S, Bollinger K. Sigma receptor ligand, (+)-pentazocine, suppresses inflammatory responses of retinal microglia. Invest Ophthalmol Vis Sci. 2014;55:3375-84 pubmed publisher
Nguyen L, Robson M, Healy J, Scandinaro A, Matsumoto R. Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan. PLoS ONE. 2014;9:e89985 pubmed publisher
Sánchez Blázquez P, Rodríguez Muñoz M, Herrero Labrador R, Burgueno J, Zamanillo D, Garzón J. The calcium-sensitive Sigma-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases. Int J Neuropsychopharmacol. 2014;17:1943-55 pubmed publisher
Iñiguez M, Punzon C, Nieto R, Burgueno J, Vela J, Fresno M. Inhibitory effects of sigma-2 receptor agonists on T lymphocyte activation. Front Pharmacol. 2013;4:23 pubmed publisher
Kourrich S, Hayashi T, Chuang J, Tsai S, SU T, Bonci A. Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine. Cell. 2013;152:236-47 pubmed publisher
Zhang C, Feng Z, Liu Y, Ji X, Peng J, Zhang X, et al. Methylphenidate enhances NMDA-receptor response in medial prefrontal cortex via sigma-1 receptor: a novel mechanism for methylphenidate action. PLoS ONE. 2012;7:e51910 pubmed publisher
Amer M, McKeown L, Tumova S, Liu R, Seymour V, Wilson L, et al. Inhibition of endothelial cell Ca²? entry and transient receptor potential channels by Sigma-1 receptor ligands. Br J Pharmacol. 2013;168:1445-55 pubmed publisher
Fishback J, Rosen A, Bhat R, McCurdy C, Matsumoto R. A 96-well filtration method for radioligand binding analysis of ? receptor ligands. J Pharm Biomed Anal. 2012;71:157-61 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Hiranita T, Soto P, Kohut S, Kopajtic T, Cao J, Newman A, et al. Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and ? receptors. J Pharmacol Exp Ther. 2011;339:662-77 pubmed publisher
Kurata K, Takebayashi M, Morinobu S, Yamawaki S. beta-estradiol, dehydroepiandrosterone, and dehydroepiandrosterone sulfate protect against N-methyl-D-aspartate-induced neurotoxicity in rat hippocampal neurons by different mechanisms. J Pharmacol Exp Ther. 2004;311:237-45 pubmed
product information
master code :
883
SKU :
0883/10
product name :
BD 1063 dihydrochloride
unit size :
10 mg (also 50 mg)
description :
Selective 1 ligand, putative antagonist
target :
Sigma1 Receptor Ligands
category :
Small Molecules
purity :
99%
observed molecular weight :
346.13
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
BD 1063 dihydrochloride is a 1 receptor antagonist, approximately 50-fold selective over 2 sites and 100-fold selective over opioid, PCP, muscarinic, dopamine, 1, 2, adrenoceptor, 5-HT1 and 5-HT2 receptors. Prevents hyperlocomotion following cocaine administration in mice.
top caption :
Selective 1 ligand, putative antagonist
extended description :
Selective 1 ligand, putative antagonist
chemical name text :
1-[2-(3,4-Dichlorophenyl)ethyl]-4-methylpiperazine dihydrochloride
formula :
C13H18Cl2N2.2HCl
formula text :
C13H18Cl2N2.2HCl
cas num :
206996-13-6
USD :
189 USD
product details :
Selective 1 ligand, putative antagonist
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK