product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
0880/10
catalog :
0880/10
quantity :
10 mg (also 50 mg)
price :
146 USD
more info or order :
citations: 45
Reference
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Padovan Neto F, Sammut S, Chakroborty S, Dec A, Threlfell S, Campbell P, et al. Facilitation of corticostriatal transmission following pharmacological inhibition of striatal phosphodiesterase 10A: role of nitric oxide-soluble guanylyl cyclase-cGMP signaling pathways. J Neurosci. 2015;35:5781-91 pubmed publisher
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Bice J, Keim Y, Stasch J, Baxter G. NO-independent stimulation or activation of soluble guanylyl cyclase during early reperfusion limits infarct size. Cardiovasc Res. 2014;101:220-8 pubmed publisher
Ho Y, Chen W, Chi T, Chang Chien C, Lee A, Chiu H, et al. Caffeic acid phenethyl amide improves glucose homeostasis and attenuates the progression of vascular dysfunction in Streptozotocin-induced diabetic rats. Cardiovasc Diabetol. 2013;12:99 pubmed publisher
Fakira A, Gaspers L, Thomas A, Li H, Jain M, Elkabes S. Purkinje cell dysfunction and delayed death in plasma membrane calcium ATPase 2-heterozygous mice. Mol Cell Neurosci. 2012;51:22-31 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Kobsar A, Koessler J, Kehrer L, Gambaryan S, Walter U. The thrombin inhibitors hirudin and Refludan(®) activate the soluble guanylyl cyclase and the cGMP pathway in washed human platelets. Thromb Haemost. 2012;107:521-9 pubmed publisher
Tseng K, Caballero A, Dec A, Cass D, Simak N, Sunu E, et al. Inhibition of striatal soluble guanylyl cyclase-cGMP signaling reverses basal ganglia dysfunction and akinesia in experimental parkinsonism. PLoS ONE. 2011;6:e27187 pubmed publisher
Chester M, Seedorf G, Tourneux P, Gien J, Tseng N, Grover T, et al. Cinaciguat, a soluble guanylate cyclase activator, augments cGMP after oxidative stress and causes pulmonary vasodilation in neonatal pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2011;301:L755-64 pubmed publisher
Harnek J, Zoucas E, de Sá V, Ekblad E, Arner A, Stenram U. Intimal hyperplasia in balloon dilated coronary arteries is reduced by local delivery of the NO donor, SIN-1 via a cGMP-dependent pathway. BMC Cardiovasc Disord. 2011;11:30 pubmed publisher
Moonen R, Villamor E. Developmental changes in mesenteric artery reactivity in embryonic and newly hatched chicks. J Comp Physiol B. 2011;181:1063-73 pubmed publisher
Yoo H, Park S, Bahk J, Kim S. Inhibition of hypoxic pulmonary vasoconstriction of rats by carbon monoxide. J Korean Med Sci. 2010;25:1411-7 pubmed publisher
Suri S, Liu X, Rayment S, Hughes D, Kroon P, Needs P, et al. Quercetin and its major metabolites selectively modulate cyclic GMP-dependent relaxations and associated tolerance in pig isolated coronary artery. Br J Pharmacol. 2010;159:566-75 pubmed publisher
Huang C, Hsu K. Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex. Cereb Cortex. 2010;20:982-96 pubmed publisher
Hoffmann L, Schmidt P, Keim Y, Schaefer S, Schmidt H, Stasch J. Distinct molecular requirements for activation or stabilization of soluble guanylyl cyclase upon haem oxidation-induced degradation. Br J Pharmacol. 2009;157:781-95 pubmed publisher
Chester M, Tourneux P, Seedorf G, Grover T, Gien J, Abman S. Cinaciguat, a soluble guanylate cyclase activator, causes potent and sustained pulmonary vasodilation in the ovine fetus. Am J Physiol Lung Cell Mol Physiol. 2009;297:L318-25 pubmed publisher
Makara J, Katona I, Nyiri G, Németh B, Ledent C, Watanabe M, et al. Involvement of nitric oxide in depolarization-induced suppression of inhibition in hippocampal pyramidal cells during activation of cholinergic receptors. J Neurosci. 2007;27:10211-22 pubmed
Newman Z, Malik P, Wu T, Ochoa C, Watsa N, Lindgren C. Endocannabinoids mediate muscarine-induced synaptic depression at the vertebrate neuromuscular junction. Eur J Neurosci. 2007;25:1619-30 pubmed
Yang S, Cox C. Modulation of inhibitory activity by nitric oxide in the thalamus. J Neurophysiol. 2007;97:3386-95 pubmed
Dalsgaard T, Simonsen U, Fago A. Nitrite-dependent vasodilation is facilitated by hypoxia and is independent of known NO-generating nitrite reductase activities. Am J Physiol Heart Circ Physiol. 2007;292:H3072-8 pubmed
Anselm E, Chataigneau M, Ndiaye M, Chataigneau T, Schini Kerth V. Grape juice causes endothelium-dependent relaxation via a redox-sensitive Src- and Akt-dependent activation of eNOS. Cardiovasc Res. 2007;73:404-13 pubmed
Agren P, Cogolludo A, Kessels C, Perez Vizcaino F, De Mey J, Blanco C, et al. Ontogeny of chicken ductus arteriosus response to oxygen and vasoconstrictors. Am J Physiol Regul Integr Comp Physiol. 2007;292:R485-96 pubmed
Cauwels A, Janssen B, Buys E, Sips P, Brouckaert P. Anaphylactic shock depends on PI3K and eNOS-derived NO. J Clin Invest. 2006;116:2244-51 pubmed
McNeish A, Sandow S, Neylon C, Chen M, Dora K, Garland C. Evidence for involvement of both IKCa and SKCa channels in hyperpolarizing responses of the rat middle cerebral artery. Stroke. 2006;37:1277-82 pubmed
Namkoong S, Lee S, Kim C, Kim Y, Chung H, Lee H, et al. Prostaglandin E2 stimulates angiogenesis by activating the nitric oxide/cGMP pathway in human umbilical vein endothelial cells. Exp Mol Med. 2005;37:588-600 pubmed
Sachs D, Cunha F, Ferreira S. Peripheral analgesic blockade of hypernociception: activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway. Proc Natl Acad Sci U S A. 2004;101:3680-5 pubmed
Cirino G, Sorrentino R, di Villa Bianca R, Popolo A, Palmieri A, Imbimbo C, et al. Involvement of beta 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function. Proc Natl Acad Sci U S A. 2003;100:5531-6 pubmed
Tsang S, Yao X, Wong C, Au C, Chen Z, Huang Y. Contribution of Na+ -Ca2+ exchanger to pinacidil-induced relaxation in the rat mesenteric artery. Br J Pharmacol. 2003;138:453-60 pubmed
Bellamy T, Garthwaite J. Pharmacology of the nitric oxide receptor, soluble guanylyl cyclase, in cerebellar cells. Br J Pharmacol. 2002;136:95-103 pubmed
Villamor E, Ruijtenbeek K, Pulgar V, De Mey J, Blanco C. Vascular reactivity in intrapulmonary arteries of chicken embryos during transition to ex ovo life. Am J Physiol Regul Integr Comp Physiol. 2002;282:R917-27 pubmed
Stanford S, Gitlin J, Mitchell J. Identification of two distinct vasodilator pathways activated by ATP in the mesenteric bed of the rat. Br J Pharmacol. 2001;133:825-32 pubmed
Casado M, Dieudonne S, Ascher P. Presynaptic N-methyl-D-aspartate receptors at the parallel fiber-Purkinje cell synapse. Proc Natl Acad Sci U S A. 2000;97:11593-7 pubmed
Haynes J. A(2A) adenosine receptor mediated potassium channel activation in rat epididymal smooth muscle. Br J Pharmacol. 2000;130:685-91 pubmed
Mundey M, Jonas M, Worthley T, Scholefield J, Wilson V. Pharmacological characterization of neurogenic responses of the sheep isolated internal anal sphincter. Br J Pharmacol. 2000;130:489-94 pubmed
Hedlund P, Aszodi A, Pfeifer A, Alm P, Hofmann F, Ahmad M, et al. Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice. Proc Natl Acad Sci U S A. 2000;97:2349-54 pubmed
Dick J, Van Geldre L, Timmermans J, Lefebvre R. Investigation of the interaction between nitric oxide and vasoactive intestinal polypeptide in the guinea-pig gastric fundus. Br J Pharmacol. 2000;129:751-63 pubmed
Perez Vizcaino F, Cogolludo A, Zaragozá Arnáez F, Fajardo S, Ibarra M, López López J, et al. Vasodilator effects of sodium nitroprusside, levcromakalim and their combination in isolated rat aorta. Br J Pharmacol. 1999;128:1419-26 pubmed
Villarroya M, Herrero C, Ruiz Nuño A, de Pascual R, del Valle M, Michelena P, et al. PF9404C, a new slow NO donor with beta receptor blocking properties. Br J Pharmacol. 1999;128:1713-22 pubmed
Rach C, Gandhi M, Docherty J, Finegan B, Clanachan A. Deficiency in myocardial NO biosignalling after cardioplegic arrest: mechanisms and contribution to post-storage mechanical dysfunction. Br J Pharmacol. 1999;128:891-902 pubmed
Cogolludo A, Perez Vizcaino F, Fajardo S, Ibarra M, Tamargo J. Effects of nicorandil as compared to mixtures of sodium nitroprusside and levcromakalim in isolated rat aorta. Br J Pharmacol. 1999;126:1025-33 pubmed
product information
master code :
880
SKU :
0880/10
product name :
ODQ
unit size :
10 mg (also 50 mg)
description :
Selective inhibitor of NO-sensitive guanylyl cyclase
target :
Additional NOS Inhibitors
category :
Small Molecules
purity :
99%
observed molecular weight :
187.16
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
ODQ is a potent and selective inhibitor of NO-sensitive guanylyl cyclase.
top caption :
Selective inhibitor of NO-sensitive guanylyl cyclase
extended description :
Selective inhibitor of NO-sensitive guanylyl cyclase
chemical name text :
1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
formula :
C9H5N3O2
formula text :
C9H5N3O2
cas num :
41443-28-1
USD :
146 USD
product details :
Selective inhibitor of NO-sensitive guanylyl cyclase
storage :
Desiccate at +4░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK