0879/10 | Tocris Bioscience 0879/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

0879/10

catalog :

0879/10

quantity :

10 mg (also 50 mg)

price :

122 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Musella A, Fresegna D, Rizzo F, Gentile A, Bullitta S, De Vito F, et al. A novel crosstalk within the endocannabinoid system controls GABA transmission in the striatum. Sci Rep. 2017;7:7363 pubmed publisher
Mattace Raso G, Pirozzi C, d Emmanuele di Villa Bianca R, Simeoli R, Santoro A, Lama A, et al. Palmitoylethanolamide treatment reduces blood pressure in spontaneously hypertensive rats: involvement of cytochrome p450-derived eicosanoids and renin angiotensin system. PLoS ONE. 2015;10:e0123602 pubmed publisher
Lin T, Lu C, Wu C, Huang S, Wang S. Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals. Int J Mol Sci. 2015;16:5555-71 pubmed publisher
Redlich S, Ribes S, Schütze S, Nau R. Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 by macrophages and increases the resistance of mice against infections. J Neuroinflammation. 2014;11:108 pubmed publisher
Esposito E, Impellizzeri D, Mazzon E, Paterniti I, Cuzzocrea S. Neuroprotective activities of palmitoylethanolamide in an animal model of Parkinson's disease. PLoS ONE. 2012;7:e41880 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Scuderi C, Valenza M, Stecca C, Esposito G, Carratu M, Steardo L. Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-?. J Neuroinflammation. 2012;9:49 pubmed publisher
Melis M, Pillolla G, Luchicchi A, Muntoni A, Yasar S, Goldberg S, et al. Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors. J Neurosci. 2008;28:13985-94 pubmed publisher
Ho W, Barrett D, Randall M. 'Entourage' effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors. Br J Pharmacol. 2008;155:837-46 pubmed publisher
Nieri P, Romiti N, Adinolfi B, Chicca A, Massarelli I, Chieli E. Modulation of P-glycoprotein activity by cannabinoid molecules in HK-2 renal cells. Br J Pharmacol. 2006;148:682-7 pubmed
Maingret F, Patel A, Lazdunski M, Honore E. The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1. EMBO J. 2001;20:47-54 pubmed

product information

master code :

879

SKU :

0879/10

product name :

Palmitoylethanolamide

unit size :

10 mg (also 50 mg)

description :

Selective GPR55 agonist. FAAH and PAA substrate

target :

GPR55 Receptor Agonists

category :

Small Molecules

observed molecular weight :

299.5

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Palmitoylethanolamide is an endogenous lipid that acts as a selective GPR55 agonist (EC50 values are 4, 19 800 and 30 000 nM at GPR55, CB2 and CB1 receptors respectively). Substrate for fatty acid amide hydrolase (FAAH) and PEA-preferring acid amidase (PAA) and exhibits antinociceptive and anticonvulsant in vivo . Directly activates PPAR (EC50 = 3 u M) producing robust anti-inflammatory actions.

top caption :

Selective GPR55 agonist. FAAH and PAA substrate

extended description :

Selective GPR55 agonist. FAAH and PAA substrate

chemical name text :

N-(2-Hydroxyethyl)hexadecanamide

formula :

C18H37NO2

formula text :

C18H37NO2

cas num :

544-31-0

USD :

122 USD

product details :

Selective GPR55 agonist. FAAH and PAA substrate

alt names :

PEA

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage