product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
0877/10
catalog :
0877/10
quantity :
10 mg (also 50 mg)
price :
219 USD
more info or order :
citations: 17
Reference
Hou B, Fu Y, Weng C, Liu W, Zhao C, Yin Z. Homeostatic Plasticity Mediated by Rod-Cone Gap Junction Coupling in Retinal Degenerative Dystrophic RCS Rats. Front Cell Neurosci. 2017;11:98 pubmed publisher
Letra Vilela R, Sánchez Sánchez A, Rocha A, Martin V, Branco Santos J, Puente Moncada N, et al. Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin. Mol Cell Endocrinol. 2016;434:238-49 pubmed publisher
Cecon E, Chen M, Marçola M, Fernandes P, Jockers R, Markus R. Amyloid β peptide directly impairs pineal gland melatonin synthesis and melatonin receptor signaling through the ERK pathway. FASEB J. 2015;29:2566-82 pubmed publisher
Nishiyama K, Hirai K. The melatonin agonist ramelteon induces duration-dependent clock gene expression through cAMP signaling in pancreatic INS-1 ?-cells. PLoS ONE. 2014;9:e102073 pubmed publisher
Chen C, Fichna J, Laudon M, Storr M. Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain. World J Gastroenterol. 2014;20:1298-304 pubmed publisher
Legros C, Devavry S, Caignard S, Tessier C, Delagrange P, Ouvry C, et al. Melatonin MT? and MT? receptors display different molecular pharmacologies only in the G-protein coupled state. Br J Pharmacol. 2014;171:186-201 pubmed publisher
Baba K, Benleulmi Chaachoua A, Journé A, Kamal M, Guillaume J, Dussaud S, et al. Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function. Sci Signal. 2013;6:ra89 pubmed publisher
Faria J, Kinote A, Ignacio Souza L, de Araújo T, Razolli D, Doneda D, et al. Melatonin acts through MT1/MT2 receptors to activate hypothalamic Akt and suppress hepatic gluconeogenesis in rats. Am J Physiol Endocrinol Metab. 2013;305:E230-42 pubmed publisher
Muxel S, Pires Lapa M, Monteiro A, Cecon E, Tamura E, Floeter Winter L, et al. NF-κB drives the synthesis of melatonin in RAW 264.7 macrophages by inducing the transcription of the arylalkylamine-N-acetyltransferase (AA-NAT) gene. PLoS ONE. 2012;7:e52010 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Kojima S, Tohei A, Ikeda M. Melatonin inhibits tachykinin NK? receptor-triggered 5-HT release from guinea pig isolated colonic mucosa. Br J Pharmacol. 2011;162:1179-85 pubmed publisher
Tunstall R, Shukla P, GRAZUL BILSKA A, Sun C, O Rourke S. MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries. J Pharmacol Exp Ther. 2011;336:127-33 pubmed publisher
Mickle A, Sood M, Zhang Z, Shahmohammadi G, Sengupta J, Miranda A. Antinociceptive effects of melatonin in a rat model of post-inflammatory visceral hyperalgesia: a centrally mediated process. Pain. 2010;149:555-64 pubmed publisher
Silva C, Tamura E, Macedo S, Cecon E, Bueno Alves L, Farsky S, et al. Melatonin inhibits nitric oxide production by microvascular endothelial cells in vivo and in vitro. Br J Pharmacol. 2007;151:195-205 pubmed
Savinainen J, Kokkola T, Salo O, Poso A, Jarvinen T, Laitinen J. Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor. Br J Pharmacol. 2005;145:636-45 pubmed
Roy D, Angelini N, Fujieda H, Brown G, Belsham D. Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin. Endocrinology. 2001;142:4711-20 pubmed
Sjöblom M, Jedstedt G, Flemstrom G. Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. J Clin Invest. 2001;108:625-33 pubmed
image
image 1 :
Tocris Bioscience 0877/10 image 1
Cat.No. 0877 - Luzindole C19H20N2O CAS No. 117946-91-5
product information
master code :
877
SKU :
0877/10
product name :
Luzindole
unit size :
10 mg (also 50 mg)
description :
Competitive melatonin MT1/MT2 antagonist
target :
Melatonin (MT) Receptor Antagonists
category :
Small Molecules
purity :
98%
observed molecular weight :
292.38
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Luzindole is a melatonin antagonist.
top caption :
Competitive melatonin MT1/MT2 antagonist
extended description :
Competitive melatonin MT1/MT2 antagonist
chemical name text :
N-Acetyl-2-benzyltryptamine
formula :
C19H20N2O
formula text :
C19H20N2O
cas num :
117946-91-5
USD :
219 USD
product details :
Competitive melatonin MT1/MT2 antagonist
storage :
Store at -20░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK