0870/10 | Tocris Bioscience 0870/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

0870/10

catalog :

0870/10

quantity :

10 mg (also 50 mg)

price :

205 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Nagata M, Yokooji T, Nakai T, Miura Y, Tomita T, Taogoshi T, et al. Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells. Sci Rep. 2019;9:16438 pubmed publisher
Corcoran A, Commons K, Wu Y, Smith J, Harris M, Richerson G. Dual effects of 5-HT(1a) receptor activation on breathing in neonatal mice. J Neurosci. 2014;34:51-9 pubmed publisher
Goda S, Piasecka J, Olszewski M, Kasicki S, Hunt M. Serotonergic hallucinogens differentially modify gamma and high frequency oscillations in the rat nucleus accumbens. Psychopharmacology (Berl). 2013;228:271-82 pubmed publisher
Williams A, Ingram W, LeVine S, Resnik J, Kamel C, Lish J, et al. Reduced levels of serotonin 2A receptors underlie resistance of Egr3-deficient mice to locomotor suppression by clozapine. Neuropsychopharmacology. 2012;37:2285-98 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Halberstadt A, Geyer M. LSD but not lisuride disrupts prepulse inhibition in rats by activating the 5-HT(2A) receptor. Psychopharmacology (Berl). 2010;208:179-89 pubmed publisher
Hodges M, Wehner M, Aungst J, Smith J, Richerson G. Transgenic mice lacking serotonin neurons have severe apnea and high mortality during development. J Neurosci. 2009;29:10341-9 pubmed publisher
Yu H, Yamaguchi A. 5-HT2C-like receptors in the brain of Xenopus laevis initiate sex-typical fictive vocalizations. J Neurophysiol. 2009;102:752-65 pubmed publisher
Ptak K, Yamanishi T, Aungst J, Milescu L, Zhang R, Richerson G, et al. Raphé neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P. J Neurosci. 2009;29:3720-37 pubmed publisher

product information

master code :

870

SKU :

0870/10

product name :

MDL 11,939

unit size :

10 mg (also 50 mg)

description :

5-HT2A antagonist

target :

5-HT2A Receptor Antagonists

category :

Small Molecules

purity :

99%

observed molecular weight :

295.42

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

MDL 11,939 is an orally active 5-HT2A receptor antagonist; displays selectivity for 5-HT2A receptors over 5-HT2C receptors (Ki values are 0.54, 2.5, 81.6 and ~10,000 nM at rabbit 5-HT2A, human 5-HT2A, rabbit 5-HT2C and human 5-HT2C receptors respectively).

top caption :

5-HT2A antagonist

extended description :

5-HT2A antagonist

chemical name text :

-Phenyl-1-(2-phenylethyl)-4-piperidinemethanol

formula :

C20H25NO

formula text :

C20H25NO

cas num :

107703-78-6

USD :

205 USD

product details :

5-HT2A antagonist

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage