Loperamide hydrochloride | Tocris Bioscience 0840 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Loperamide hydrochloride

catalog :

0840

quantity :

1 g

price :

100 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Sałaga M, Kowalczuk A, Zielinska M, Błażewicz A, Fichna J. Calea zacatechichi dichloromethane extract exhibits antidiarrheal and antinociceptive effects in mouse models mimicking irritable bowel syndrome. Naunyn Schmiedebergs Arch Pharmacol. 2015;388:1069-77 pubmed publisher

product information

brand :

Tocris

master code :

0840

SKU :

0840/1G

product name :

Loperamide hydrochloride

description :

Peripherally acting u agonist; Ca2+ channel blocker

target :

mu Opioid Receptor Agonists

category :

Small Molecules

unit size :

1 g

purity :

99%

observed molecular weight :

513.51

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

High affinity u -opioid receptor agonist with peripheral selectivity (Ki values are 2, 48 and 1156 nM for u -, - and -opioid receptors respectively). Antidiarrhoeal and antihyperalgesic agent. Also a Ca2+ channel blocker; at low micromolar concentrations it blocks broad spectrum neuronal HVA Ca2+ channels and at higher concentrations it reduces Ca2+ flux through NMDA receptor operated channels. Inhbits replication of MERS-CoV and SARS-CoV in vitro .

catalog number base :

840

product keywords :

Ca2+ channel blockers HVA L/N-type NMDA antagonists reduces flux Peripherally peripheral -opioid mu-opioid agonists Calcium CaV Channels L-Type N-Type voltage-gated voltage-dependent Glutamate Receptors N-Methyl-D-Aspartate iGluR Ionotropic MOP OP3 Mu Opioid Receptors NMDA Receptors Cav1.x Channels Cav2.x Channels COVID-19 Coronavirus 0840,

extended description :

Peripherally acting u agonist; Ca2+ channel blocker

chemical name text :

4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl- , -diphenyl-1-piperidinebutanamide hydrochloride

formula :

C 29 H 33 ClN 2 O 2 .HCl

formula text :

C29H33ClN2O2.HCl

cas num :

34552-83-5

2020 USD :

2021 USD :

100 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage