product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
ICI 118,551 hydrochloride
catalog :
0821
quantity :
10 mg (also 50 mg)
price :
198 USD
more info or order :
citations: 43
Reference |
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Liu Y, Wu S, Wang G, Huang N, Liu C. A long-acting β2-adrenergic agonist increases the expression of muscarine cholinergic subtype‑3 receptors by activating the β2-adrenoceptor cyclic adenosine monophosphate signaling pathway in airway smooth muscle cells. Mol Med Rep. 2015;11:4121-8 pubmed publisher
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Crestani C, Alves F, Resstel L, Correa F. Both alpha1 and alpha2-adrenoceptors mediate the cardiovascular responses to noradrenaline microinjected into the bed nucleus of the stria terminal of rats. Br J Pharmacol. 2008;153:583-90 pubmed
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Jane wit D, Altuntas C, Johnson J, Yong S, Wickley P, Clark P, et al. Beta 1-adrenergic receptor autoantibodies mediate dilated cardiomyopathy by agonistically inducing cardiomyocyte apoptosis. Circulation. 2007;116:399-410 pubmed
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Maupoil V, Bronquard C, Freslon J, Cosnay P, Findlay I. Ectopic activity in the rat pulmonary vein can arise from simultaneous activation of alpha1- and beta1-adrenoceptors. Br J Pharmacol. 2007;150:899-905 pubmed
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Nackley A, Tan K, Fecho K, Flood P, Diatchenko L, Maixner W. Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors. Pain. 2007;128:199-208 pubmed
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Hucho T, Dina O, Levine J. Epac mediates a cAMP-to-PKC signaling in inflammatory pain: an isolectin B4(+) neuron-specific mechanism. J Neurosci. 2005;25:6119-26 pubmed
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Kwolek G, Zakrzeska A, Schlicker E, Gothert M, Godlewski G, Malinowska B. Central and peripheral components of the pressor effect of anandamide in urethane-anaesthetized rats. Br J Pharmacol. 2005;145:567-75 pubmed
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de Coupade C, Gear R, Dazin P, Sroussi H, Green P, Levine J. Beta 2-adrenergic receptor regulation of human neutrophil function is sexually dimorphic. Br J Pharmacol. 2004;143:1033-41 pubmed
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Cardin J, Schmidt M. Noradrenergic inputs mediate state dependence of auditory responses in the avian song system. J Neurosci. 2004;24:7745-53 pubmed
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Chanrachakul B, Broughton Pipkin F, Khan R. Contribution of coupling between human myometrial beta2-adrenoreceptor and the BK(Ca) channel to uterine quiescence. Am J Physiol Cell Physiol. 2004;287:C1747-52 pubmed
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Brixius K, Bundkirchen A, Bölck B, Mehlhorn U, Schwinger R. Nebivolol, bucindolol, metoprolol and carvedilol are devoid of intrinsic sympathomimetic activity in human myocardium. Br J Pharmacol. 2001;133:1330-8 pubmed
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Heubach J, Graf E, Molenaar P, Jager A, Schroder F, Herzig S, et al. Murine ventricular L-type Ca(2+) current is enhanced by zinterol via beta(1)-adrenoceptors, and is reduced in TG4 mice overexpressing the human beta(2)-adrenoceptor. Br J Pharmacol. 2001;133:73-82 pubmed
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Nagaraja S, Iyer S, Liu X, Eichberg J, Bond R. Treatment with inverse agonists enhances baseline atrial contractility in transgenic mice with chronic beta2-adrenoceptor activation. Br J Pharmacol. 1999;127:1099-104 pubmed
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product information
brand :
Tocris
master code :
0821
SKU :
0821/10
product name :
ICI 118,551 hydrochloride
description :
Highly selective 2 inverse agonist
target :
Adrenergic beta 2 Receptor Inverse Agonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
313.87
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Very selective 2 adrenergic inverse agonist (Ki values are 1.2, 120 and 257 nM for 2, 1 and 3 receptors respectively). Active in vivo . Also available as part of the -Adrenoceptor Antagonist Tocriset .
catalog number base :
821
product keywords :
selective 2-adrenoceptors 2-adrenoceptor beta2-adrenoceptors b2-adrenoceptors b2-adrenergic 2-adrenergic 2-adrenergic beta2-adrenergic antagonists Receptors ICI118551 hydrochloride AstraZeneca inverse agonist agonism Adrenergic Beta-2 Receptors 0821,
extended description :
Highly selective 2 inverse agonist
chemical name text :
( )-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride
formula :
C 17 H 27 NO 2 .HCl
formula text :
C17H27NO2.HCl
cas num :
72795-01-8
2020 USD :
188
2021 USD :
198 USD
storage :
Store at RT
more info or order :
company information

Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com800-343-7475
headquarters: UK
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