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company name :
Tocris Bioscience
product type :
chemical
product name :
0821/10
catalog :
0821/10
quantity :
10 mg (also 50 mg)
price :
262 USD
more info or order :
citations: 47
Reference
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Pecha S, Flenner F, Söhren K, Lorenz K, Eschenhagen T, Christ T. β 1 Adrenoceptor antagonistic effects of the supposedly selective β 2 adrenoceptor antagonist ICI 118,551 on the positive inotropic effect of adrenaline in murine hearts. Pharmacol Res Perspect. 2015;3:e00168 pubmed publisher
Sun F, Ding X, An S, Tang Y, Yang X, Teng L, et al. Adrenergic DNA damage of embryonic pluripotent cells via β2 receptor signalling. Sci Rep. 2015;5:15950 pubmed publisher
Littmann T, Göttle M, Reinartz M, Kälble S, Wainer I, Ozawa T, et al. Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands. J Pharmacol Exp Ther. 2015;355:183-90 pubmed publisher
Stoddart L, Johnstone E, Wheal A, Goulding J, Robers M, Machleidt T, et al. Application of BRET to monitor ligand binding to GPCRs. Nat Methods. 2015;12:661-663 pubmed publisher
Kim Y, Elmenhorst D, Weisshaupt A, Wedekind F, Kroll T, McCarley R, et al. Chronic sleep restriction induces long-lasting changes in adenosine and noradrenaline receptor density in the rat brain. J Sleep Res. 2015;24:549-558 pubmed publisher
Liu Y, Wu S, Wang G, Huang N, Liu C. A long-acting β2-adrenergic agonist increases the expression of muscarine cholinergic subtype‑3 receptors by activating the β2-adrenoceptor cyclic adenosine monophosphate signaling pathway in airway smooth muscle cells. Mol Med Rep. 2015;11:4121-8 pubmed publisher
Dasu M, Ramirez S, La T, Gorouhi F, Nguyen C, Lin B, et al. Crosstalk between adrenergic and toll-like receptors in human mesenchymal stem cells and keratinocytes: a recipe for impaired wound healing. Stem Cells Transl Med. 2014;3:745-59 pubmed publisher
Li X, Nooh M, Bahouth S. Role of AKAP79/150 protein in ?1-adrenergic receptor trafficking and signaling in mammalian cells. J Biol Chem. 2013;288:33797-812 pubmed publisher
Hott S, Gomes F, Fabri D, Reis D, Crestani C, Correa F, et al. Both ?1- and ?1-adrenoceptors in the bed nucleus of the stria terminalis are involved in the expression of conditioned contextual fear. Br J Pharmacol. 2012;167:207-21 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Qian H, Matt L, Zhang M, Nguyen M, Patriarchi T, Koval O, et al. ?2-Adrenergic receptor supports prolonged theta tetanus-induced LTP. J Neurophysiol. 2012;107:2703-12 pubmed publisher
Rankovic V, Landgraf P, Kanyshkova T, Ehling P, Meuth S, Kreutz M, et al. Modulation of calcium-dependent inactivation of L-type Ca2+ channels via ?-adrenergic signaling in thalamocortical relay neurons. PLoS ONE. 2011;6:e27474 pubmed publisher
Cheng G, Kasiganesan H, Baicu C, Wallenborn J, Kuppuswamy D, Cooper G. Cytoskeletal role in protection of the failing heart by ?-adrenergic blockade. Am J Physiol Heart Circ Physiol. 2012;302:H675-87 pubmed publisher
Schutsky K, Ouyang M, Castelino C, Zhang L, Thomas S. Stress and glucocorticoids impair memory retrieval via ?2-adrenergic, Gi/o-coupled suppression of cAMP signaling. J Neurosci. 2011;31:14172-81 pubmed publisher
Hisadome K, Reimann F, Gribble F, Trapp S. CCK stimulation of GLP-1 neurons involves α1-adrenoceptor-mediated increase in glutamatergic synaptic inputs. Diabetes. 2011;60:2701-9 pubmed publisher
Sucharov C, Dockstader K, Nunley K, McKinsey T, Bristow M. ?-Adrenergic receptor stimulation and activation of protein kinase A protect against ?1-adrenergic-mediated phosphorylation of protein kinase D and histone deacetylase 5. J Card Fail. 2011;17:592-600 pubmed publisher
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Cardin J, Schmidt M. Noradrenergic inputs mediate state dependence of auditory responses in the avian song system. J Neurosci. 2004;24:7745-53 pubmed
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product information
master code :
821
SKU :
0821/10
product name :
ICI 118,551 hydrochloride
unit size :
10 mg (also 50 mg)
description :
Highly selective 2 inverse agonist
target :
Adrenergic beta 2 Receptor Inverse Agonists
category :
Small Molecules
purity :
98%
observed molecular weight :
313.87
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
ICI 118,551 hydrochloride is a very selective 2 adrenergic inverse agonist (Ki values are 1.2, 120 and 257 nM for 2, 1 and 3 receptors respectively). Active in vivo .
top caption :
Highly selective 2 inverse agonist
extended description :
Highly selective 2 inverse agonist
chemical name text :
( )-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride
formula :
C17H27NO2.HCl
formula text :
C17H27NO2.HCl
cas num :
72795-01-8
USD :
262 USD
product details :
Highly selective 2 inverse agonist
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK