product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
0807/50
catalog :
0807/50
quantity :
50 mg
price :
205 USD
more info or order :
citations: 14
Reference
Ki Y, Lim C. Sleep-promoting effects of threonine link amino acid metabolism in Drosophila neuron to GABAergic control of sleep drive. elife. 2019;8: pubmed publisher
Green M, Thayer S. HIV gp120 upregulates tonic inhibition through α5-containing GABAARs. Neuropharmacology. 2019;149:161-168 pubmed publisher
Montandon G, Wu H, Liu H, Vu M, Orser B, Horner R. δ-Subunit Containing GABAA Receptors Modulate Respiratory Networks. Sci Rep. 2017;7:18105 pubmed publisher
Patel B, Bright D, Mortensen M, Frølund B, Smart T. Context-Dependent Modulation of GABAAR-Mediated Tonic Currents. J Neurosci. 2016;36:607-21 pubmed publisher
Tong X, Peng Z, Zhang N, Cetina Y, Huang C, Wallner M, et al. Ectopic Expression of α6 and δ GABAA Receptor Subunits in Hilar Somatostatin Neurons Increases Tonic Inhibition and Alters Network Activity in the Dentate Gyrus. J Neurosci. 2015;35:16142-58 pubmed publisher
Seifi M, Brown J, Mills J, Bhandari P, Belelli D, Lambert J, et al. Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon. J Neurosci. 2014;34:10361-78 pubmed publisher
Szemes M, Davies R, Garden C, Usowicz M. Weaker control of the electrical properties of cerebellar granule cells by tonically active GABAA receptors in the Ts65Dn mouse model of Down's syndrome. Mol Brain. 2013;6:33 pubmed publisher
Ramaker M, Strong M, Ford M, Finn D. Effect of ganaxolone and THIP on operant and limited-access ethanol self-administration. Neuropharmacology. 2012;63:555-64 pubmed publisher
Asiedu M, Mejia G, Ossipov M, Malan T, Kaila K, Price T. Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice. J Pain. 2012;13:546-54 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Yue L, Xie A, Bruzik K, Frølund B, Qian H, Pepperberg D. Potentiating action of propofol at GABAA receptors of retinal bipolar cells. Invest Ophthalmol Vis Sci. 2011;52:2497-509 pubmed publisher
Schmid M, Mrowka S, Turchi J, Saunders R, Wilke M, Peters A, et al. Blindsight depends on the lateral geniculate nucleus. Nature. 2010;466:373-7 pubmed publisher
Krook Magnuson E, Li P, Paluszkiewicz S, Huntsman M. Tonically active inhibition selectively controls feedforward circuits in mouse barrel cortex. J Neurophysiol. 2008;100:932-44 pubmed publisher
Glykys J, Mody I. Hippocampal network hyperactivity after selective reduction of tonic inhibition in GABA A receptor alpha5 subunit-deficient mice. J Neurophysiol. 2006;95:2796-807 pubmed
product information
master code :
807
SKU :
0807/50
product name :
THIP hydrochloride
unit size :
50 mg
description :
GABAA agonist
target :
GABA-A Receptor Agonists
category :
Small Molecules
purity :
98%
observed molecular weight :
176.6
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
THIP hydrochloride is a systemically active GABAA receptor agonist and GABAA- receptor antagonist. Displays antinociceptive, anticonvulsant and sedative effects. Hypnotic agent that enhances delta activity within non-REM sleep in rats.
top caption :
GABAA agonist
extended description :
GABAA agonist
chemical name text :
4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride
formula :
C6H8N2O2.HCl
formula text :
C6H8N2O2.HCl
cas num :
85118-33-8
USD :
205 USD
product details :
GABAA agonist
alt names :
Gaboxadol
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK