product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
(S)-3,5-DHPG
catalog :
0805
quantity :
10 mg
price :
300 USD
more info or order :
citations: 37
Reference
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Hellmer C, Clemons M, Nawy S, Ichinose T. A group I metabotropic glutamate receptor controls synaptic gain between rods and rod bipolar cells in the mouse retina. Physiol Rep. 2018;6:e13885 pubmed publisher
Morel C, Sherrin T, Kennedy N, Forest K, Avcioglu Barutcu S, Robles M, et al. JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory. J Neurosci. 2018;38:3708-3728 pubmed publisher
Hashimotodani Y, Nasrallah K, Jensen K, Chavez A, Carrera D, Castillo P. LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance. Neuron. 2017;95:928-943.e3 pubmed publisher
Musella A, Fresegna D, Rizzo F, Gentile A, Bullitta S, De Vito F, et al. A novel crosstalk within the endocannabinoid system controls GABA transmission in the striatum. Sci Rep. 2017;7:7363 pubmed publisher
Pallo S, DiMaio J, Cook A, Nilsson B, Johnson G. Mechanisms of tau and Aβ-induced excitotoxicity. Brain Res. 2016;1634:119-131 pubmed publisher
Henderson M, Baldwin H, Werley C, Boccardo S, Whitaker L, Yan X, et al. A Low Affinity GCaMP3 Variant (GCaMPer) for Imaging the Endoplasmic Reticulum Calcium Store. PLoS ONE. 2015;10:e0139273 pubmed publisher
Aguilar Valles A, Matta Camacho E, Khoutorsky A, Gkogkas C, Nader K, Lacaille J, et al. Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2. J Neurosci. 2015;35:11125-32 pubmed publisher
Ifrim M, Williams K, Bassell G. Single-Molecule Imaging of PSD-95 mRNA Translation in Dendrites and Its Dysregulation in a Mouse Model of Fragile X Syndrome. J Neurosci. 2015;35:7116-30 pubmed publisher
Tang A, Alger B. Homer protein-metabotropic glutamate receptor binding regulates endocannabinoid signaling and affects hyperexcitability in a mouse model of fragile X syndrome. J Neurosci. 2015;35:3938-45 pubmed publisher
Tang W, Szokol K, Jensen V, Enger R, Trivedi C, Hvalby Ø, et al. Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP. J Neurosci. 2015;35:3016-21 pubmed publisher
Pollard M, Bartolome J, Conn P, Steckler T, Shaban H. Modulation of neuronal microcircuit activities within the medial prefrontal cortex by mGluR5 positive allosteric modulator. J Psychopharmacol. 2014;28:935-46 pubmed publisher
Careaga M, Noyon T, Basuta K, Van de Water J, Tassone F, Hagerman R, et al. Group I metabotropic glutamate receptor mediated dynamic immune dysfunction in children with fragile X syndrome. J Neuroinflammation. 2014;11:110 pubmed publisher
Zhao L, Levine E. BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling. J Neurophysiol. 2014;111:1008-15 pubmed publisher
Kuribayashi N, Uchida D, Kinouchi M, Takamaru N, Tamatani T, Nagai H, et al. The role of metabotropic glutamate receptor 5 on the stromal cell-derived factor-1/CXCR4 system in oral cancer. PLoS ONE. 2013;8:e80773 pubmed publisher
Fairless R, Beck A, Kravchenko M, Williams S, Wissenbach U, Diem R, et al. Membrane potential measurements of isolated neurons using a voltage-sensitive dye. PLoS ONE. 2013;8:e58260 pubmed publisher
McQuail J, Davis K, Miller F, Hampson R, Deadwyler S, Howlett A, et al. Hippocampal G?q/?? but not G?o-coupled receptors are altered in aging. Neuropharmacology. 2013;70:63-73 pubmed publisher
Péterfi Z, Urbán G, Papp O, Németh B, Monyer H, Szabó G, et al. Endocannabinoid-mediated long-term depression of afferent excitatory synapses in hippocampal pyramidal cells and GABAergic interneurons. J Neurosci. 2012;32:14448-63 pubmed publisher
Bozdagi O, Sakurai T, Dorr N, Pilorge M, Takahashi N, Buxbaum J. Haploinsufficiency of Cyfip1 produces fragile X-like phenotypes in mice. PLoS ONE. 2012;7:e42422 pubmed publisher
Gregg L, Jung K, Spradley J, Nyilas R, Suplita R, Zimmer A, et al. Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-? initiates 2-arachidonoylglycerol formation and endocannabinoid-mediated analgesia. J Neurosci. 2012;32:9457-68 pubmed publisher
Taman A, Ribeiro P. Characterization of a truncated metabotropic glutamate receptor in a primitive metazoan, the parasitic flatworm Schistosoma mansoni. PLoS ONE. 2011;6:e27119 pubmed publisher
Zhao W, Chuang S, Bianchi R, Wong R. Dual regulation of fragile X mental retardation protein by group I metabotropic glutamate receptors controls translation-dependent epileptogenesis in the hippocampus. J Neurosci. 2011;31:725-34 pubmed publisher
Filippov A, Simon J, Barnard E, Brown D. The scaffold protein NHERF2 determines the coupling of P2Y1 nucleotide and mGluR5 glutamate receptor to different ion channels in neurons. J Neurosci. 2010;30:11068-72 pubmed publisher
Fu L, van den Pol A. Kisspeptin directly excites anorexigenic proopiomelanocortin neurons but inhibits orexigenic neuropeptide Y cells by an indirect synaptic mechanism. J Neurosci. 2010;30:10205-19 pubmed publisher
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Westmark C, Malter J. FMRP mediates mGluR5-dependent translation of amyloid precursor protein. PLoS Biol. 2007;5:e52 pubmed
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El Kouhen O, Lehto S, Pan J, Chang R, Baker S, Zhong C, et al. Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist. Br J Pharmacol. 2006;149:761-74 pubmed
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Paladini C, Robinson S, Morikawa H, Williams J, Palmiter R. Dopamine controls the firing pattern of dopamine neurons via a network feedback mechanism. Proc Natl Acad Sci U S A. 2003;100:2866-71 pubmed
product information
brand :
Tocris
master code :
0805
SKU :
0805/10
product name :
(S)-3,5-DHPG
description :
Selective group I mGlu agonist; active enantiomer of 3,5-DHPG (Cat. No. 0342)
target :
Group I mGluR Agonists
category :
Small Molecules
unit size :
10 mg
purity :
98%
observed molecular weight :
183.16
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Selective group I mGlu receptor agonist. . Racemate also available.
catalog number base :
805
product keywords :
Selective group I agonists Active enantiomer Group Receptors mGlu1 mGlu5 mGluR1 mGluR5 Glutamate Metabotropic Glutamate (Metabotropic) Group I Receptors 0805,
extended description :
Selective group I mGlu agonist; active enantiomer of 3,5-DHPG (Cat. No. 0342)
chemical name text :
(S)-3,5-Dihydroxyphenylglycine
formula :
C 8 H 9 NO 4
formula text :
C8H9NO4
cas num :
162870-29-3
2020 USD :
285
2021 USD :
300 USD
storage :
Desiccate at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK