product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
0805/5
catalog :
0805/5
quantity :
5 mg (also 10 mg)
price :
209 USD
more info or order :
citations: 44
Reference
Mercuri N, Federici M, Rizzo F, Maugeri L, D Addario S, Ventura R, et al. Long-Term Depression of Striatal DA Release Induced by mGluRs via Sustained Hyperactivity of Local Cholinergic Interneurons. Front Cell Neurosci. 2021;15:798464 pubmed publisher
Paul A, Nawalpuri B, Shah D, Sateesh S, Muddashetty R, Clement J. Differential Regulation of Syngap1 Translation by FMRP Modulates eEF2 Mediated Response on NMDAR Activity. Front Mol Neurosci. 2019;12:97 pubmed publisher
Hellmer C, Clemons M, Nawy S, Ichinose T. A group I metabotropic glutamate receptor controls synaptic gain between rods and rod bipolar cells in the mouse retina. Physiol Rep. 2018;6:e13885 pubmed publisher
Govindaiah G, Kang Y, Lewis H, Chung L, Clement E, Greenfield L, et al. Group I metabotropic glutamate receptors generate two types of intrinsic membrane oscillations in hippocampal oriens/alveus interneurons. Neuropharmacology. 2018;139:150-162 pubmed publisher
Morel C, Sherrin T, Kennedy N, Forest K, Avcioglu Barutcu S, Robles M, et al. JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory. J Neurosci. 2018;38:3708-3728 pubmed publisher
Hashimotodani Y, Nasrallah K, Jensen K, Chavez A, Carrera D, Castillo P. LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance. Neuron. 2017;95:928-943.e3 pubmed publisher
Musella A, Fresegna D, Rizzo F, Gentile A, Bullitta S, De Vito F, et al. A novel crosstalk within the endocannabinoid system controls GABA transmission in the striatum. Sci Rep. 2017;7:7363 pubmed publisher
Pallo S, DiMaio J, Cook A, Nilsson B, Johnson G. Mechanisms of tau and Aβ-induced excitotoxicity. Brain Res. 2016;1634:119-131 pubmed publisher
Henderson M, Baldwin H, Werley C, Boccardo S, Whitaker L, Yan X, et al. A Low Affinity GCaMP3 Variant (GCaMPer) for Imaging the Endoplasmic Reticulum Calcium Store. PLoS ONE. 2015;10:e0139273 pubmed publisher
Aguilar Valles A, Matta Camacho E, Khoutorsky A, Gkogkas C, Nader K, Lacaille J, et al. Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2. J Neurosci. 2015;35:11125-32 pubmed publisher
Ifrim M, Williams K, Bassell G. Single-Molecule Imaging of PSD-95 mRNA Translation in Dendrites and Its Dysregulation in a Mouse Model of Fragile X Syndrome. J Neurosci. 2015;35:7116-30 pubmed publisher
Kalinowska M, Chávez A, Lutzu S, Castillo P, Bukauskas F, Francesconi A. Actinin-4 Governs Dendritic Spine Dynamics and Promotes Their Remodeling by Metabotropic Glutamate Receptors. J Biol Chem. 2015;290:15909-20 pubmed publisher
Tang A, Alger B. Homer protein-metabotropic glutamate receptor binding regulates endocannabinoid signaling and affects hyperexcitability in a mouse model of fragile X syndrome. J Neurosci. 2015;35:3938-45 pubmed publisher
Tang W, Szokol K, Jensen V, Enger R, Trivedi C, Hvalby Ø, et al. Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP. J Neurosci. 2015;35:3016-21 pubmed publisher
Pollard M, Bartolome J, Conn P, Steckler T, Shaban H. Modulation of neuronal microcircuit activities within the medial prefrontal cortex by mGluR5 positive allosteric modulator. J Psychopharmacol. 2014;28:935-46 pubmed publisher
Careaga M, Noyon T, Basuta K, Van de Water J, Tassone F, Hagerman R, et al. Group I metabotropic glutamate receptor mediated dynamic immune dysfunction in children with fragile X syndrome. J Neuroinflammation. 2014;11:110 pubmed publisher
Zhao L, Levine E. BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling. J Neurophysiol. 2014;111:1008-15 pubmed publisher
Kuribayashi N, Uchida D, Kinouchi M, Takamaru N, Tamatani T, Nagai H, et al. The role of metabotropic glutamate receptor 5 on the stromal cell-derived factor-1/CXCR4 system in oral cancer. PLoS ONE. 2013;8:e80773 pubmed publisher
Fairless R, Beck A, Kravchenko M, Williams S, Wissenbach U, Diem R, et al. Membrane potential measurements of isolated neurons using a voltage-sensitive dye. PLoS ONE. 2013;8:e58260 pubmed publisher
Whitaker L, Degoulet M, Morikawa H. Social deprivation enhances VTA synaptic plasticity and drug-induced contextual learning. Neuron. 2013;77:335-45 pubmed publisher
McQuail J, Davis K, Miller F, Hampson R, Deadwyler S, Howlett A, et al. Hippocampal G?q/?? but not G?o-coupled receptors are altered in aging. Neuropharmacology. 2013;70:63-73 pubmed publisher
Péterfi Z, Urbán G, Papp O, Németh B, Monyer H, Szabó G, et al. Endocannabinoid-mediated long-term depression of afferent excitatory synapses in hippocampal pyramidal cells and GABAergic interneurons. J Neurosci. 2012;32:14448-63 pubmed publisher
Bozdagi O, Sakurai T, Dorr N, Pilorge M, Takahashi N, Buxbaum J. Haploinsufficiency of Cyfip1 produces fragile X-like phenotypes in mice. PLoS ONE. 2012;7:e42422 pubmed publisher
Gregg L, Jung K, Spradley J, Nyilas R, Suplita R, Zimmer A, et al. Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-? initiates 2-arachidonoylglycerol formation and endocannabinoid-mediated analgesia. J Neurosci. 2012;32:9457-68 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Cruz Martin A, Crespo M, Portera Cailliau C. Glutamate induces the elongation of early dendritic protrusions via mGluRs in wild type mice, but not in fragile X mice. PLoS ONE. 2012;7:e32446 pubmed publisher
Lusardi T, Thompson S, MacDonald I, Lan J, Theofilas P, Saugstad J. Effect of (S)-3,5-DHPG on microRNA expression in mouse brain. Exp Neurol. 2012;235:497-507 pubmed publisher
Taman A, Ribeiro P. Characterization of a truncated metabotropic glutamate receptor in a primitive metazoan, the parasitic flatworm Schistosoma mansoni. PLoS ONE. 2011;6:e27119 pubmed publisher
Zhao W, Chuang S, Bianchi R, Wong R. Dual regulation of fragile X mental retardation protein by group I metabotropic glutamate receptors controls translation-dependent epileptogenesis in the hippocampus. J Neurosci. 2011;31:725-34 pubmed publisher
Filippov A, Simon J, Barnard E, Brown D. The scaffold protein NHERF2 determines the coupling of P2Y1 nucleotide and mGluR5 glutamate receptor to different ion channels in neurons. J Neurosci. 2010;30:11068-72 pubmed publisher
Fu L, van den Pol A. Kisspeptin directly excites anorexigenic proopiomelanocortin neurons but inhibits orexigenic neuropeptide Y cells by an indirect synaptic mechanism. J Neurosci. 2010;30:10205-19 pubmed publisher
Pan Y, Karr L, Rutecki P. Ictal activity induced by group I metabotropic glutamate receptor activation and loss of afterhyperpolarizations. Neuropharmacology. 2010;59:86-92 pubmed publisher
Nakamoto M, Nalavadi V, Epstein M, Narayanan U, Bassell G, Warren S. Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors. Proc Natl Acad Sci U S A. 2007;104:15537-42 pubmed
Fukunaga I, Yeo C, Batchelor A. Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices. Br J Pharmacol. 2007;151:870-6 pubmed
Westmark C, Malter J. FMRP mediates mGluR5-dependent translation of amyloid precursor protein. PLoS Biol. 2007;5:e52 pubmed
Xu W, Wong T, Chery N, Gaertner T, Wang Y, Baudry M. Calpain-mediated mGluR1alpha truncation: a key step in excitotoxicity. Neuron. 2007;53:399-412 pubmed
Ruangkittisakul A, Schwarzacher S, Secchia L, Poon B, Ma Y, Funk G, et al. High sensitivity to neuromodulator-activated signaling pathways at physiological [K+] of confocally imaged respiratory center neurons in on-line-calibrated newborn rat brainstem slices. J Neurosci. 2006;26:11870-80 pubmed
El Kouhen O, Lehto S, Pan J, Chang R, Baker S, Zhong C, et al. Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist. Br J Pharmacol. 2006;149:761-74 pubmed
Kuang D, Yao Y, MacLean D, Wang M, Hampson D, Chang B. Ancestral reconstruction of the ligand-binding pocket of Family C G protein-coupled receptors. Proc Natl Acad Sci U S A. 2006;103:14050-5 pubmed
Jung K, Mangieri R, Stapleton C, Kim J, Fegley D, Wallace M, et al. Stimulation of endocannabinoid formation in brain slice cultures through activation of group I metabotropic glutamate receptors. Mol Pharmacol. 2005;68:1196-202 pubmed
Jacob S, Choe C, Uhlen P, Degray B, Yeckel M, Ehrlich B. Signaling microdomains regulate inositol 1,4,5-trisphosphate-mediated intracellular calcium transients in cultured neurons. J Neurosci. 2005;25:2853-64 pubmed
Wu M, Hajszan T, Xu C, Leranth C, Alreja M. Group I metabotropic glutamate receptor activation produces a direct excitation of identified septohippocampal cholinergic neurons. J Neurophysiol. 2004;92:1216-25 pubmed
Cai W, Hisatsune C, Nakamura K, Nakamura T, Inoue T, Mikoshiba K. Activity-dependent expression of inositol 1,4,5-trisphosphate receptor type 1 in hippocampal neurons. J Biol Chem. 2004;279:23691-8 pubmed
Paladini C, Robinson S, Morikawa H, Williams J, Palmiter R. Dopamine controls the firing pattern of dopamine neurons via a network feedback mechanism. Proc Natl Acad Sci U S A. 2003;100:2866-71 pubmed
product information
master code :
805
SKU :
0805/5
product name :
(S)-3,5-DHPG
unit size :
5 mg (also 10 mg)
description :
Selective group I mGlu agonist; active enantiomer of 3,5-DHPG (Cat. No. 0342)
target :
Group I mGluR Agonists
category :
Small Molecules
purity :
98%
observed molecular weight :
183.16
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
( S )-3,5-DHPG is a selective group I mGlu receptor agonist. (S)-3,5-DHPG regulates the expression of microRNAs in mouse cerebral cortex in vivo . (S)-3,5-DHPG induces a profound depression of synaptic dopamine release in mouse cortico-striatal cells in vitro , and anxiety-like behavior in vivo in mice. . Racemate also available.
top caption :
Selective group I mGlu agonist; active enantiomer of 3,5-DHPG (Cat. No. 0342)
extended description :
Selective group I mGlu agonist; active enantiomer of 3,5-DHPG (Cat. No. 0342)
chemical name text :
(S)-3,5-Dihydroxyphenylglycine
formula :
C8H9NO4
formula text :
C8H9NO4
cas num :
162870-29-3
USD :
209 USD
product details :
Selective group I mGlu agonist; active enantiomer of 3,5-DHPG (Cat. No. 0342)
storage :
Desiccate at -20░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK