product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
0796/10
catalog :
0796/10
quantity :
10 mg (also 50 mg)
price :
122 USD
more info or order :
citations: 15
Reference
Styr B, Gonen N, Zarhin D, Ruggiero A, Atsmon R, Gazit N, et al. Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility. Neuron. 2019;102:1009-1024.e8 pubmed publisher
Chai H, Diaz Castro B, Shigetomi E, Monte E, Octeau J, Yu X, et al. Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence. Neuron. 2017;95:531-549.e9 pubmed publisher
Kirwan P, Turner Bridger B, Peter M, Momoh A, Arambepola D, Robinson H, et al. Development and function of human cerebral cortex neural networks from pluripotent stem cells in vitro. Development. 2015;142:3178-87 pubmed publisher
Bragina L, Bonifacino T, Bassi S, Milanese M, Bonanno G, Conti F. Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals. Front Cell Neurosci. 2015;9:345 pubmed publisher
Wang P, Eshaq R, Meshul C, Moore C, Hood R, Leidenheimer N. Neuronal gamma-aminobutyric acid (GABA) type A receptors undergo cognate ligand chaperoning in the endoplasmic reticulum by endogenous GABA. Front Cell Neurosci. 2015;9:188 pubmed publisher
Zhang W, Xu C, Tu H, Wang Y, Sun Q, Hu P, et al. GABAB receptor upregulates fragile X mental retardation protein expression in neurons. Sci Rep. 2015;5:10468 pubmed publisher
Xia Y, Zhao Y, Yang M, Zeng S, Shu Y. Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons. PLoS ONE. 2014;9:e100968 pubmed publisher
Kang S, Liu M, Shi T, Zhao M, Kaang B, Zhuo M. N-type voltage gated calcium channels mediate excitatory synaptic transmission in the anterior cingulate cortex of adult mice. Mol Pain. 2013;9:58 pubmed publisher
Klug J, Mathur B, Kash T, Wang H, Matthews R, Robison A, et al. Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability. PLoS ONE. 2012;7:e45323 pubmed publisher
Messer R, Levine E. Epileptiform activity in the CA1 region of the hippocampus becomes refractory to attenuation by cannabinoids in part because of endogenous γ-aminobutyric acid type B receptor activity. J Neurosci Res. 2012;90:1454-63 pubmed publisher
Hensler J, Advani T, Burke T, Cheng K, Rice K, Koek W. GABAB receptor-positive modulators: brain region-dependent effects. J Pharmacol Exp Ther. 2012;340:19-26 pubmed publisher
Pacey L, Tharmalingam S, Hampson D. Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome. J Pharmacol Exp Ther. 2011;338:897-905 pubmed publisher
Lobb C, Wilson C, Paladini C. A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons. J Neurophysiol. 2010;104:403-13 pubmed publisher
Bartoi T, Rigbolt K, Du D, Köhr G, Blagoev B, Kornau H. GABAB receptor constituents revealed by tandem affinity purification from transgenic mice. J Biol Chem. 2010;285:20625-33 pubmed publisher
Piqueras L, Martinez V. Peripheral GABAB agonists stimulate gastric acid secretion in mice. Br J Pharmacol. 2004;142:1038-48 pubmed
product information
master code :
796
SKU :
0796/10
product name :
(R)-Baclofen
unit size :
10 mg (also 50 mg)
description :
Selective GABAB agonist; active enantiomer of (RS)-Baclofen (Cat. No. 0417)
target :
GABA-B Receptor Agonists
category :
Small Molecules
purity :
99%
observed molecular weight :
213.66
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
More active enantiomer of ( RS )-Baclofen, a selective GABAB agonist. . Racemate also available.
top caption :
Selective GABAB agonist; active enantiomer of (RS)-Baclofen (Cat. No. 0417)
extended description :
Selective GABAB agonist; active enantiomer of (RS)-Baclofen (Cat. No. 0417)
chemical name text :
(R)-4-Amino-3-(4-chlorophenyl)butanoic acid
formula :
C10H12ClNO2
formula text :
C10H12ClNO2
cas num :
69308-37-8
USD :
122 USD
product details :
Selective GABAB agonist; active enantiomer of (RS)-Baclofen (Cat. No. 0417)
alt names :
STX 209
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK