0773/50 | Tocris Bioscience 0773/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

0773/50

catalog :

0773/50

quantity :

50 mg

price :

148 USD

more info or order :

Tocris Bioscience product webpage

citations: 19

Reference
Bali Z, Bruszt N, Tadepalli S, Csurgyók R, Nagy L, Tompa M, et al. Cognitive Enhancer Effects of Low Memantine Doses Are Facilitated by an Alpha7 Nicotinic Acetylcholine Receptor Agonist in Scopolamine-Induced Amnesia in Rats. Front Pharmacol. 2019;10:73 pubmed publisher
Bouchard Cannon P, Lowden C, Trinh D, Cheng H. Dexras1 is a homeostatic regulator of exercise-dependent proliferation and cell survival in the hippocampal neurogenic niche. Sci Rep. 2018;8:5294 pubmed publisher
Sachser R, Santana F, Crestani A, Lunardi P, Pedraza L, Quillfeldt J, et al. Forgetting of long-term memory requires activation of NMDA receptors, L-type voltage-dependent Ca2+ channels, and calcineurin. Sci Rep. 2016;6:22771 pubmed publisher
Birnbaum J, Bali J, Rajendran L, Nitsch R, Tackenberg C. Calcium flux-independent NMDA receptor activity is required for AÎ² oligomer-induced synaptic loss. Cell Death Dis. 2015;6:e1791 pubmed publisher
Campbell S, Hablitz J, Olsen M. Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia. Front Cell Neurosci. 2014;8:425 pubmed publisher
Simma N, Bose T, Kahlfuss S, Mankiewicz J, Lowinus T, LÃ¼hder F, et al. NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells. Cell Commun Signal. 2014;12:75 pubmed publisher
Brison E, Jacomy H, Desforges M, Talbot P. Novel treatment with neuroprotective and antiviral properties against a neuroinvasive human respiratory virus. J Virol. 2014;88:1548-63 pubmed publisher
He S, Bausch S. Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic memantine treatment in an in vitro model of limbic epileptogenesis. Neuropharmacology. 2014;77:379-86 pubmed publisher
Carlson S, Kempsell A, Fieber L. Pharmacological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica. Brain Behav. 2012;2:391-401 pubmed publisher
Kaufman A, Milnerwood A, Sepers M, Coquinco A, She K, Wang L, et al. Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons. J Neurosci. 2012;32:3992-4003 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Hedegaard M, Hansen K, Andersen K, Brauner Osborne H, Traynelis S. Molecular pharmacology of human NMDA receptors. Neurochem Int. 2012;61:601-9 pubmed publisher
Puddifoot C, Chen P, Schoepfer R, Wyllie D. Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes. Br J Pharmacol. 2009;156:509-18 pubmed publisher
Fan W, Cooper N. Glutamate-induced NFkappaB activation in the retina. Invest Ophthalmol Vis Sci. 2009;50:917-25 pubmed publisher
Leveille F, El Gaamouch F, Gouix E, Lecocq M, Lobner D, Nicole O, et al. Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors. FASEB J. 2008;22:4258-71 pubmed publisher
Costa C, Belcastro V, Tozzi A, Di Filippo M, Tantucci M, Siliquini S, et al. Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition. J Neurosci. 2008;28:8040-52 pubmed publisher
Manning S, Talos D, Zhou C, Selip D, Park H, Park C, et al. NMDA receptor blockade with memantine attenuates white matter injury in a rat model of periventricular leukomalacia. J Neurosci. 2008;28:6670-8 pubmed publisher
Jaekel B, Mühlberg K, Garcia de Arriba S, Reichenbach A, Verdaguer E, Pallas M, et al. Neuroprotection associated with alternative splicing of NMDA receptors in rat cortical neurons. Br J Pharmacol. 2006;147:622-33 pubmed
Rzeski W, Turski L, Ikonomidou C. Glutamate antagonists limit tumor growth. Proc Natl Acad Sci U S A. 2001;98:6372-7 pubmed

product information

master code :

773

SKU :

0773/50

product name :

Memantine hydrochloride

unit size :

50 mg

description :

NMDA antagonist; acts at ion channel site

target :

NMDA Receptor Antagonists

category :

Small Molecules

observed molecular weight :

215.77

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Memantine hydrochloride is an antagonist at the NMDA receptor (IC50 = 0.5 -1.5 M in vitro ), binding to the ion channel site. Memantine increases BDNF protein and mRNA levels in the brain in vivo . In an animal model of Alzheimer s disease, memantine improves spatial learning and decreases deposition of A plaques. Memantine has neuroprotective effects in dopaminergic neurons; stimulates release of neurotrophic factor from astroglia and reduces microglia inflammation in vitro .

top caption :

NMDA antagonist; acts at ion channel site

extended description :

NMDA antagonist; acts at ion channel site

chemical name text :

3,5-Dimethyl-tricyclo[3.3.1.13,7]decan-1-amine hydrochloride

formula :

C12H21N.HCl

formula text :

C12H21N.HCl

cas num :

41100-52-1

USD :

148 USD

product details :

NMDA antagonist; acts at ion channel site

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage