Riluzole hydrochloride | Tocris Bioscience 0768 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Riluzole hydrochloride

catalog :

0768

quantity :

25 mg

price :

106 USD

more info or order :

Tocris Bioscience product webpage

citations: 14

Reference
Shin S, Jeong B, Wall B, Li J, Shan N, Wen Y, et al. Participation of xCT in melanoma cell proliferation in vitro and tumorigenesis in vivo. Oncogenesis. 2018;7:86 pubmed publisher
Sexton R, Hachem A, Assi A, Bukhsh M, Gorski D, Speyer C. Metabotropic glutamate receptor-1 regulates inflammation in triple negative breast cancer. Sci Rep. 2018;8:16008 pubmed publisher
Zhang Y, Reynolds J, Cragg S. Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification, with Dopamine Modulation. Neuron. 2018;98:918-925.e3 pubmed publisher
Sperling S, Aung T, Martin S, Rohde V, Ninkovic M. Riluzole: a potential therapeutic intervention in human brain tumor stem-like cells. Oncotarget. 2017;8:96697-96709 pubmed publisher
Dolfi S, Medina D, Kareddula A, Paratala B, Rose A, Dhami J, et al. Riluzole exerts distinct antitumor effects from a metabotropic glutamate receptor 1-specific inhibitor on breast cancer cells. Oncotarget. 2017;8:44639-44653 pubmed publisher
Du Z, Chen H, Liu H, Lu J, Qian K, Huang C, et al. Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells. Nat Commun. 2015;6:6626 pubmed publisher
Rosenberg S, Niglio S, Salehomoum N, Chan J, Jeong B, Wen Y, et al. Targeting Glutamatergic Signaling and the PI3 Kinase Pathway to Halt Melanoma Progression. Transl Oncol. 2015;8:1-9 pubmed publisher
Valiya Veettil M, Dutta D, Bottero V, Bandyopadhyay C, Gjyshi O, Sharma Walia N, et al. Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation. PLoS Pathog. 2014;10:e1004389 pubmed publisher
Viemari J, Garcia A, Doi A, ELSEN G, Ramirez J. β-Noradrenergic receptor activation specifically modulates the generation of sighs in vivo and in vitro. Front Neural Circuits. 2013;7:179 pubmed publisher
Park Y, Johnston D, Gray R. Slowly inactivating component of Na+ current in peri-somatic region of hippocampal CA1 pyramidal neurons. J Neurophysiol. 2013;109:1378-90 pubmed publisher
Carbone M, Duty S, Rattray M. Riluzole neuroprotection in a Parkinson's disease model involves suppression of reactive astrocytosis but not GLT-1 regulation. BMC Neurosci. 2012;13:38 pubmed publisher
Carbone M, Duty S, Rattray M. Riluzole elevates GLT-1 activity and levels in striatal astrocytes. Neurochem Int. 2012;60:31-8 pubmed publisher
Le M, Chan J, Rosenberg S, Nabatian A, Merrigan K, Cohen Solal K, et al. The glutamate release inhibitor Riluzole decreases migration, invasion, and proliferation of melanoma cells. J Invest Dermatol. 2010;130:2240-9 pubmed publisher
Morgado Valle C, Baca S, Feldman J. Glycinergic pacemaker neurons in preBötzinger complex of neonatal mouse. J Neurosci. 2010;30:3634-9 pubmed publisher

product information

brand :

Tocris

master code :

0768

SKU :

0768/25

product name :

Riluzole hydrochloride

description :

GABA uptake inhibitor; also inhibits glutamate release and blocks NaV channels

target :

Glutamate Receptor Inhibitors

category :

Small Molecules

unit size :

25 mg

purity :

98%

observed molecular weight :

270.66

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibits glutamate release from presynaptic terminals and increases Na+-dependent glutamate uptake in rat cortical synaptosomes. Blocks voltage-dependent Na+ channels and inhibits GABA uptake by striatal synaptosomes. Also activates TRPC5 channels. Psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic, anesthetic and neuroprotective properties.

catalog number base :

768

product keywords :

Glutamate release inhibitors inhibits GABA uptake Na+ channel blockers glutamate mGlur Receptors Metabotropic Sodium NaV Channels voltage-gated voltage-dependent iGlu Ionotropic BGT-1 GAT Transporters Monoamine Neurotransmitter neuroprotective TRPC5 canon Miscellaneous Glutamate GABA Transporters Voltage-gated Sodium Channels TRPC 0768,

extended description :

GABA uptake inhibitor; also inhibits glutamate release and blocks NaV channels

chemical name text :

2-Amino-6-trifluoromethoxybenzothiazole hydrochloride

formula :

C 8 H 5 F 3 N 2 OS.HCl

formula text :

C8H5F3N2OS.HCl

cas num :

850608-87-6

2020 USD :

103

2021 USD :

106 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage