product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
SNC 80
catalog :
0764
quantity :
10 mg (also 50 mg)
price :
225 USD
more info or order :
citations: 18
Reference
Robins M, Chiang T, Mores K, Alongkronrusmee D, van Rijn R. Critical Role for Gi/o-Protein Activity in the Dorsal Striatum in the Reduction of Voluntary Alcohol Intake in C57Bl/6 Mice. Front Psychiatry. 2018;9:112 pubmed publisher
Wang D, Tawfik V, Corder G, Low S, Francois A, Basbaum A, et al. Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits. Neuron. 2018;98:90-108.e5 pubmed publisher
Ye Y, Bernabé D, Salvo E, Viet C, Ono K, Dolan J, et al. Alterations in opioid inhibition cause widespread nociception but do not affect anxiety-like behavior in oral cancer mice. Neuroscience. 2017;363:50-61 pubmed publisher
Levoye A, Zwier J, Jaracz Ros A, Klipfel L, Cottet M, Maurel D, et al. A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate. Front Endocrinol (Lausanne). 2015;6:167 pubmed publisher
Neumann C, Bigliardi Qi M, Widmann C, Bigliardi P. The δ-opioid receptor affects epidermal homeostasis via ERK-dependent inhibition of transcription factor POU2F3. J Invest Dermatol. 2015;135:471-480 pubmed publisher
Schuster D, Metcalf M, Kitto K, Messing R, Fairbanks C, Wilcox G. Ligand requirements for involvement of PKC? in synergistic analgesic interactions between spinal ? and ? opioid receptors. Br J Pharmacol. 2015;172:642-53 pubmed publisher
Ong E, Xue L, Olmstead M, Cahill C. Prolonged morphine treatment alters ? opioid receptor post-internalization trafficking. Br J Pharmacol. 2015;172:615-29 pubmed publisher
Erbs E, Faget L, Scherrer G, Matifas A, Filliol D, Vonesch J, et al. A mu-delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks. Brain Struct Funct. 2015;220:677-702 pubmed publisher
Pradhan A, Smith M, Zyuzin J, Charles A. δ-Opioid receptor agonists inhibit migraine-related hyperalgesia, aversive state and cortical spreading depression in mice. Br J Pharmacol. 2014;171:2375-84 pubmed publisher
Milan Lobo L, Enquist J, van Rijn R, Whistler J. Anti-analgesic effect of the mu/delta opioid receptor heteromer revealed by ligand-biased antagonism. PLoS ONE. 2013;8:e58362 pubmed publisher
Burbassi S, Sengupta R, Meucci O. Alterations of CXCR4 function in ?-opioid receptor-deficient glia. Eur J Neurosci. 2010;32:1278-88 pubmed publisher
Butelman E, Rus S, Prisinzano T, Kreek M. The discriminative effects of the kappa-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects. Psychopharmacology (Berl). 2010;210:253-62 pubmed publisher
Pacheco D, Klein A, Perez A, Pacheco C, de Francischi J, Reis G, et al. Central antinociception induced by mu-opioid receptor agonist morphine, but not delta- or kappa-, is mediated by cannabinoid CB1 receptor. Br J Pharmacol. 2009;158:225-31 pubmed publisher
Markkanen P, Petäjä Repo U. N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface. J Biol Chem. 2008;283:29086-98 pubmed publisher
da Fonseca Pacheco D, Klein A, de Castro Perez A, da Fonseca Pacheco C, de Francischi J, Duarte I. The mu-opioid receptor agonist morphine, but not agonists at delta- or kappa-opioid receptors, induces peripheral antinociception mediated by cannabinoid receptors. Br J Pharmacol. 2008;154:1143-9 pubmed publisher
Scherrer G, Tryoen Toth P, Filliol D, Matifas A, Laustriat D, Cao Y, et al. Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo. Proc Natl Acad Sci U S A. 2006;103:9691-6 pubmed
Sluka K, Rohlwing J, Bussey R, Eikenberry S, Wilken J. Chronic muscle pain induced by repeated acid Injection is reversed by spinally administered mu- and delta-, but not kappa-, opioid receptor agonists. J Pharmacol Exp Ther. 2002;302:1146-50 pubmed
Gomes I, Jordan B, Gupta A, Trapaidze N, Nagy V, Devi L. Heterodimerization of mu and delta opioid receptors: A role in opiate synergy. J Neurosci. 2000;20:RC110 pubmed
product information
brand :
Tocris
master code :
0764
SKU :
0764/10
product name :
SNC 80
description :
Highly selective non-peptide agonist
target :
delta Opioid Receptor Agonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
449.64
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
A highly selective and potent non-peptide -opioid agonist, 2000-fold selective over u -opioid receptors.
catalog number base :
764
product keywords :
selective non-peptide -opioid delta-opioid agonists DOP Receptors OP1 SNC80 Delta Opioid Receptors 0764,
extended description :
Highly selective non-peptide agonist
chemical name text :
(+)-4-[( R)- -((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide
formula :
C 28 H 39 N 3 O 2
formula text :
C28H39N3O2
cas num :
156727-74-1
2020 USD :
214
2021 USD :
225 USD
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK