0760/10 | Tocris Bioscience 0760/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

0760/10

catalog :

0760/10

quantity :

10 mg (also 50 mg)

price :

229 USD

more info or order :

Tocris Bioscience product webpage

citations: 16

Reference
Ping W, Hu J, Hu G, Song Y, Xia Q, Yao M, et al. Genome-wide DNA methylation analysis reveals that mouse chemical iPSCs have closer epigenetic features to mESCs than OSKM-integrated iPSCs. Cell Death Dis. 2018;9:187 pubmed publisher
Lee J, Protze S, Laksman Z, Backx P, Keller G. Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations. Cell Stem Cell. 2017;21:179-194.e4 pubmed publisher
Li X, Liu D, Ma Y, Du X, Jing J, Wang L, et al. Direct Reprogramming of Fibroblasts via a Chemically Induced XEN-like State. Cell Stem Cell. 2017;21:264-273.e7 pubmed publisher
Kelley M, Phomakay R, Lee M, Niedzwiedz V, Mayo R. Retinoic acid receptor gamma impacts cellular adhesion, Alpha5Beta1 integrin expression and proliferation in K562 cells. PLoS ONE. 2017;12:e0178116 pubmed publisher
Chronopoulos A, Robinson B, Sarper M, Cortés E, Auernheimer V, Lachowski D, et al. ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion. Nat Commun. 2016;7:12630 pubmed publisher
Brigger D, Schläfli A, Garattini E, Tschan M. Activation of RARα induces autophagy in SKBR3 breast cancer cells and depletion of key autophagy genes enhances ATRA toxicity. Cell Death Dis. 2015;6:e1861 pubmed publisher
Centritto F, Paroni G, Bolis M, Garattini S, Kurosaki M, Barzago M, et al. Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARÎ± expression. EMBO Mol Med. 2015;7:950-72 pubmed publisher
Whelan J, Wang L, Chen J, Metts M, Nasser T, McGoldrick L, et al. Retinoids induce integrin-independent lymphocyte adhesion through RAR-Î± nuclear receptor activity. Biochem Biophys Res Commun. 2014;454:537-42 pubmed publisher
Perri M, Yap J, Yu J, Cione E, Fletcher S, KANE M. BCL-xL/MCL-1 inhibition and RARγ antagonism work cooperatively in human HL60 leukemia cells. Exp Cell Res. 2014;327:183-91 pubmed publisher
Sarang Z, Joós G, Garabuczi E, Ruhl R, Gregory C, Szondy Z. Macrophages engulfing apoptotic cells produce nonclassical retinoids to enhance their phagocytic capacity. J Immunol. 2014;192:5730-8 pubmed publisher
Johansson H, Sanchez B, Mundt F, Forshed J, Kovács A, Panizza E, et al. Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer. Nat Commun. 2013;4:2175 pubmed publisher
Huk D, Hammond H, Kegechika H, Lincoln J. Increased dietary intake of vitamin A promotes aortic valve calcification in vivo. Arterioscler Thromb Vasc Biol. 2013;33:285-93 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Wingert R, Davidson A. Zebrafish nephrogenesis involves dynamic spatiotemporal expression changes in renal progenitors and essential signals from retinoic acid and irx3b. Dev Dyn. 2011;240:2011-27 pubmed publisher
Depaolo R, Abadie V, Tang F, Fehlner Peach H, Hall J, Wang W, et al. Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature. 2011;471:220-4 pubmed publisher
Kang S, Park J, Cho J, Ulrich B, Kim C. Complementary roles of retinoic acid and TGF-?1 in coordinated expression of mucosal integrins by T cells. Mucosal Immunol. 2011;4:66-82 pubmed publisher

product information

master code :

760

SKU :

0760/10

product name :

AM 580

unit size :

10 mg (also 50 mg)

description :

Retinoic acid analog; RAR agonist

target :

Retinoic Acid Receptor Agonists

category :

Small Molecules

purity :

98%

observed molecular weight :

351.44

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AM 580 is an analog of retinoic acid that acts as a selective RAR agonist (EC50 values are 0.3, 8.6 and 13 nM for RAR , RAR and RAR respectively). Significantly induces IL-4, IL-5 and IL-13 and inhibits IL-12 and IFN synthesis, and induces cell differentiation with over 7 times the activity of retinoic acid in vitro . . AM 580 synthesized to Ancillary Material Grade also available.

top caption :

Retinoic acid analog; RAR agonist

extended description :

Retinoic acid analog; RAR agonist

chemical name text :

4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido]benzoic acid

formula :

C22H25NO3

formula text :

C22H25NO3

cas num :

102121-60-8

USD :

229 USD

product details :

Retinoic acid analog; RAR agonist

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage