Clobenpropit dihydrobromide | Tocris Bioscience 0752 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Clobenpropit dihydrobromide

catalog :

0752

quantity :

10 mg (also 50 mg)

price :

193 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Alkan M, Machavoine F, Rignault R, Dam J, Dy M, Thieblemont N. Histidine Decarboxylase Deficiency Prevents Autoimmune Diabetes in NOD Mice. J Diabetes Res. 2015;2015:965056 pubmed publisher
FemenÃa T, Magara S, DuPont C, Lindskog M. Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression. Int J Neuropsychopharmacol. 2015;18: pubmed publisher
Hedegaard M, Hansen K, Andersen K, Brauner Osborne H, Traynelis S. Molecular pharmacology of human NMDA receptors. Neurochem Int. 2012;61:601-9 pubmed publisher
Flamand N, Plante H, Picard S, Laviolette M, Borgeat P. Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP. Br J Pharmacol. 2004;141:552-61 pubmed

product information

brand :

Tocris

master code :

0752

SKU :

0752/10

product name :

Clobenpropit dihydrobromide

description :

Highly potent H3 antagonist and H4 partial agonist

target :

Histamine H3 Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

470.65

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

An extremely potent histamine H3 antagonist/inverse agonist (pA2=9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.

catalog number base :

752

product keywords :

H4 partial agonists H3 antagonists inverse potent Receptors Histamine histaminergic VUF9153 VUF 9153 Histamine H3 Receptors Histamine H4 Receptors 0752,

extended description :

Highly potent H3 antagonist and H4 partial agonist

chemical name text :

N-(4-Chlorobenzyl)-S-[3-(4(5)-imidazolyl)propyl]isothiourea dihydrobromide

formula :

C 14 H 17 ClN 4 S.2HBr

formula text :

C14H17ClN4S.2HBr

cas num :

145231-35-2

2020 USD :

185

2021 USD :

193 USD

alt names :

VUF 9153

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage