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company name :
Tocris Bioscience
product type :
chemical
product name :
0752/10
catalog :
0752/10
quantity :
10 mg (also 50 mg)
price :
243 USD
more info or order :
citations: 5
Reference
Alkan M, Machavoine F, Rignault R, Dam J, Dy M, Thieblemont N. Histidine Decarboxylase Deficiency Prevents Autoimmune Diabetes in NOD Mice. J Diabetes Res. 2015;2015:965056 pubmed publisher
Femenía T, Magara S, DuPont C, Lindskog M. Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression. Int J Neuropsychopharmacol. 2015;18: pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Hedegaard M, Hansen K, Andersen K, Brauner Osborne H, Traynelis S. Molecular pharmacology of human NMDA receptors. Neurochem Int. 2012;61:601-9 pubmed publisher
Flamand N, Plante H, Picard S, Laviolette M, Borgeat P. Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP. Br J Pharmacol. 2004;141:552-61 pubmed
product information
master code :
752
SKU :
0752/10
product name :
Clobenpropit dihydrobromide
unit size :
10 mg (also 50 mg)
description :
Highly potent H3 antagonist and H4 partial agonist
target :
Histamine H3 Receptor Antagonists
category :
Small Molecules
purity :
99%
observed molecular weight :
470.65
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
An extremely potent histamine H3 antagonist/inverse agonist (pA2=9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.
top caption :
Highly potent H3 antagonist and H4 partial agonist
extended description :
Highly potent H3 antagonist and H4 partial agonist
chemical name text :
N-(4-Chlorobenzyl)-S-[3-(4(5)-imidazolyl)propyl]isothiourea dihydrobromide
formula :
C14H17ClN4S.2HBr
formula text :
C14H17ClN4S.2HBr
cas num :
145231-35-2
USD :
243 USD
product details :
Highly potent H3 antagonist and H4 partial agonist
alt names :
VUF 9153
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK