product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
0742/10
catalog :
0742/10
quantity :
10 mg (also 50 mg)
price :
276 USD
more info or order :
citations: 11
Reference
Wall M, Collins D, Chery S, Allen Z, Pastuzyn E, George A, et al. The Temporal Dynamics of Arc Expression Regulate Cognitive Flexibility. Neuron. 2018;98:1124-1132.e7 pubmed publisher
Park P, Sanderson T, Amici M, Choi S, Bortolotto Z, Zhuo M, et al. Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus. J Neurosci. 2016;36:622-31 pubmed publisher
Fang X, Qiao H, Groveman B, Feng S, Pflueger M, Xin W, et al. Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors. Mol Brain. 2015;8:75 pubmed publisher
Dennis S, Pasqui F, Colvin E, Sanger H, Mogg A, Felder C, et al. Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus. Cereb Cortex. 2016;26:414-26 pubmed publisher
Clarke V, Molchanova S, Hirvonen T, Taira T, Lauri S. Activity-dependent upregulation of presynaptic kainate receptors at immature CA3-CA1 synapses. J Neurosci. 2014;34:16902-16 pubmed publisher
Ng A, Doherty A, Lombroso P, Emptage N, Collingridge G. Rapid regulation of endoplasmic reticulum dynamics in dendritic spines by NMDA receptor activation. Mol Brain. 2014;7:60 pubmed publisher
Eales K, Palygin O, O Loughlin T, Rasooli Nejad S, Gaestel M, M Ller J, et al. The MK2/3 cascade regulates AMPAR trafficking and cognitive flexibility. Nat Commun. 2014;5:4701 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Potier B, Turpin F, Sinet P, Rouaud E, Mothet J, Videau C, et al. Contribution of the d-Serine-Dependent Pathway to the Cellular Mechanisms Underlying Cognitive Aging. Front Aging Neurosci. 2010;2:1 pubmed publisher
Dargan S, Clarke V, Alushin G, Sherwood J, Nisticò R, Bortolotto Z, et al. ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function. Neuropharmacology. 2009;56:121-30 pubmed publisher
Rouaud E, Billard J. D-cycloserine facilitates synaptic plasticity but impairs glutamatergic neurotransmission in rat hippocampal slices. Br J Pharmacol. 2003;140:1051-6 pubmed
product information
master code :
742
SKU :
0742/10
product name :
L-689,560
unit size :
10 mg (also 50 mg)
description :
Highly potent NMDA antagonist
target :
NMDA Receptor Antagonists
category :
Small Molecules
purity :
99%
observed molecular weight :
380.23
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
L-689,560 is a very potent antagonist at the glycine-NMDA site.
top caption :
Highly potent NMDA antagonist
extended description :
Highly potent NMDA antagonist
chemical name text :
trans-2-Carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline
formula :
C17H15Cl2N3O3
formula text :
C17H15Cl2N3O3
cas num :
139051-78-8
USD :
276 USD
product details :
Highly potent NMDA antagonist
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK