2-Iodomelatonin | Tocris Bioscience 0737 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

2-Iodomelatonin

catalog :

0737

quantity :

10 mg (also 50 mg)

price :

72 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Akoume M, Elbakry M, Veillette M, Franco A, Nada D, Labelle H, et al. A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep. 2019;9:10074 pubmed publisher
Stauch B, Johansson L, McCorvy J, Patel N, Han G, Huang X, et al. Structural basis of ligand recognition at the human MT1 melatonin receptor. Nature. 2019;569:284-288 pubmed publisher
Hou B, Fu Y, Weng C, Liu W, Zhao C, Yin Z. Homeostatic Plasticity Mediated by Rod-Cone Gap Junction Coupling in Retinal Degenerative Dystrophic RCS Rats. Front Cell Neurosci. 2017;11:98 pubmed publisher
Calamini B, Santarsiero B, Boutin J, Mesecar A. Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2. Biochem J. 2008;413:81-91 pubmed publisher
Nosjean O, Ferro M, Coge F, Beauverger P, Henlin J, Lefoulon F, et al. Identification of the melatonin-binding site MT3 as the quinone reductase 2. J Biol Chem. 2000;275:31311-7 pubmed

product information

brand :

Tocris

master code :

0737

SKU :

0737/10

product name :

2-Iodomelatonin

description :

High affinity melatonin agonist

target :

Melatonin (MT) Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

358.18

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent melatonin agonist (pKi values are 10.55 and 9.87 at human recombinant MT1 and MT2 receptors respectively). 2-[125I]-iodomelatonin has been used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues.

catalog number base :

737

product keywords :

High affinity melatonin agonists MT Receptors Melatonin (MT) Receptors 0737,

extended description :

High affinity melatonin agonist

chemical name text :

N-[2-(2-Iodo-5-methoxyindol-3-yl)ethyl]acetamide

formula :

C 13 H 15 IN 2 O 2

formula text :

C13H15IN2O2

cas num :

93515-00-5

2020 USD :

2021 USD :

72 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage