2-Iodomelatonin | Tocris Bioscience 0737/10 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

2-Iodomelatonin

catalog :

0737/10

quantity :

10 mg (also 50 mg)

price :

91 USD

citations: 6

Reference
Akoume M, Elbakry M, Veillette M, Franco A, Nada D, Labelle H, et al. A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep. 2019;9:10074 pubmed publisher
Stauch B, Johansson L, McCorvy J, Patel N, Han G, Huang X, et al. Structural basis of ligand recognition at the human MT1 melatonin receptor. Nature. 2019;569:284-288 pubmed publisher
Hou B, Fu Y, Weng C, Liu W, Zhao C, Yin Z. Homeostatic Plasticity Mediated by Rod-Cone Gap Junction Coupling in Retinal Degenerative Dystrophic RCS Rats. Front Cell Neurosci. 2017;11:98 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Calamini B, Santarsiero B, Boutin J, Mesecar A. Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2. Biochem J. 2008;413:81-91 pubmed publisher
Nosjean O, Ferro M, Coge F, Beauverger P, Henlin J, Lefoulon F, et al. Identification of the melatonin-binding site MT3 as the quinone reductase 2. J Biol Chem. 2000;275:31311-7 pubmed

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

0737

SKU :

0737/10

product name :

2-Iodomelatonin

description :

High affinity melatonin agonist

target :

Melatonin (MT) Receptor Agonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

358.18

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

2-Iodomelatonin is a potent melatonin agonist (pKi values are 10.55 and 9.87 at human recombinant MT1 and MT2 receptors respectively). 2-[125I]-iodomelatonin has been used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues.

product keywords :

High affinity melatonin agonists MT Receptors Melatonin (MT) Receptors 0737,

extended description :

High affinity melatonin agonist

chemical name text :

N-[2-(2-Iodo-5-methoxyindol-3-yl)ethyl]acetamide

formula :

C13H15IN2O2

formula text :

C13H15IN2O2

cas num :

93515-00-5

USD :

USD 2025 :

91 USD

product details :

High affinity melatonin agonist