Imetit dihydrobromide | Tocris Bioscience 0729 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Imetit dihydrobromide

catalog :

0729

quantity :

10 mg (also 50 mg)

price :

124 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Hashikawa Hobara N, Chan N, Levi R. Histamine 3 receptor activation reduces the expression of neuronal angiotensin II type 1 receptors in the heart. J Pharmacol Exp Ther. 2012;340:185-91 pubmed publisher
Yoshimoto R, Miyamoto Y, Shimamura K, Ishihara A, Takahashi K, Kotani H, et al. Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus. Proc Natl Acad Sci U S A. 2006;103:13866-71 pubmed
Flamand N, Plante H, Picard S, Laviolette M, Borgeat P. Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP. Br J Pharmacol. 2004;141:552-61 pubmed

product information

brand :

Tocris

master code :

0729

SKU :

0729/10

product name :

Imetit dihydrobromide

description :

Standard H3 and H4 agonist (H3 H4)

target :

Histamine H3 Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

332.06

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

An extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC50 of 25 nM. Centrally active following systemic administration.

catalog number base :

729

product keywords :

H3 H4 agonists Receptors Histamine histaminergic Histamine H3 Receptors Histamine H4 Receptors 0729,

extended description :

Standard H3 and H4 agonist (H3 H4)

chemical name text :

5-[2-(Imidazol-4-yl)ethyl]isothiourea dihydrobromide

formula :

C 6 H 10 N 4 S.2HBr

formula text :

C6H10N4S.2HBr

cas num :

32385-58-3

2020 USD :

120

2021 USD :

124 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage