0729/10 | Tocris Bioscience 0729/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

0729/10

catalog :

0729/10

quantity :

10 mg (also 50 mg)

price :

157 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Hashikawa Hobara N, Chan N, Levi R. Histamine 3 receptor activation reduces the expression of neuronal angiotensin II type 1 receptors in the heart. J Pharmacol Exp Ther. 2012;340:185-91 pubmed publisher
Yoshimoto R, Miyamoto Y, Shimamura K, Ishihara A, Takahashi K, Kotani H, et al. Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus. Proc Natl Acad Sci U S A. 2006;103:13866-71 pubmed
Flamand N, Plante H, Picard S, Laviolette M, Borgeat P. Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP. Br J Pharmacol. 2004;141:552-61 pubmed

product information

master code :

729

SKU :

0729/10

product name :

Imetit dihydrobromide

unit size :

10 mg (also 50 mg)

description :

Standard H3 and H4 agonist (H3 H4)

target :

Histamine H3 Receptor Agonists

category :

Small Molecules

purity :

98%

observed molecular weight :

332.06

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Imetit dihydrobromide is an an extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC50 of 25 nM. Centrally active following systemic administration.

top caption :

Standard H3 and H4 agonist (H3 H4)

extended description :

Standard H3 and H4 agonist (H3 H4)

chemical name text :

5-[2-(Imidazol-4-yl)ethyl]isothiourea dihydrobromide

formula :

C6H10N4S.2HBr

formula text :

C6H10N4S.2HBr

cas num :

32385-58-3

USD :

157 USD

product details :

Standard H3 and H4 agonist (H3 H4)

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage