BU 224 hydrochloride | Tocris Bioscience 0725 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BU 224 hydrochloride

catalog :

0725

quantity :

10 mg (also 50 mg)

price :

133 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Gründemann D, Koschker A, Haag C, Honold C, Zimmermann T, Schömig E. Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells. Br J Pharmacol. 2002;137:910-8 pubmed
Sánchez Blázquez P, Boronat M, Olmos G, García Sevilla J, Garzon J. Activation of I(2)-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol. 2000;130:146-52 pubmed

product information

brand :

Tocris

master code :

0725

SKU :

0725/10

product name :

BU 224 hydrochloride

description :

Potent, selective I2 ligand. Putative antagonist

target :

Imidazoline 2 (I2) Receptor Ligands

category :

Small Molecules

unit size :

10 mg (also 50 mg)

observed molecular weight :

233.7

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

High affinity ligand for the imidazoline I2 binding site (Ki = 2.1 nM). Putative I2 antagonist; antagonizes the effects of imidazoline ligands on morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.

catalog number base :

725

product keywords :

Potent selective I2 ligand Putative antagonists Imidazoline Receptors BU224 hydrochloride I2 Receptors 0725,

extended description :

Potent, selective I2 ligand. Putative antagonist

chemical name text :

2-(4,5-Dihydroimidazol-2-yl)quinoline hydrochloride

formula :

C 12 H 11 N 3 .HCl

formula text :

C12H11N3.HCl

cas num :

205437-64-5

2020 USD :

133

2021 USD :

133 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage