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company name :
Tocris Bioscience
product type :
chemical
product name :
0713/10
catalog :
0713/10
quantity :
10 mg (also 50 mg)
price :
112 USD
more info or order :
citations: 24
Reference
Fan L, Nehme R, Adam Y, Jung E, Wu H, Eggan K, et al. All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition. Nat Methods. 2018;15:823-831 pubmed publisher
Bretin S, Louis C, Seguin L, Wagner S, Thomas J, Challal S, et al. Pharmacological characterisation of S 47445, a novel positive allosteric modulator of AMPA receptors. PLoS ONE. 2017;12:e0184429 pubmed publisher
Imlach W, Bhola R, Mohammadi S, Christie M. Glycinergic dysfunction in a subpopulation of dorsal horn interneurons in a rat model of neuropathic pain. Sci Rep. 2016;6:37104 pubmed publisher
McGee T, Bats C, Farrant M, Cull Candy S. Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function. J Neurosci. 2015;35:16171-9 pubmed publisher
Di Angelantonio S, Bertollini C, Piccinin S, Rosito M, Trettel F, Pagani F, et al. Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R. Front Cell Neurosci. 2015;9:409 pubmed publisher
Falgairolle M, O Donovan M. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. PLoS ONE. 2015;10:e0131430 pubmed publisher
Seebohm G, Wrobel E, Pusch M, Dicks M, Terhag J, Matschke V, et al. Structural basis of PI(4,5)P2-dependent regulation of GluA1 by phosphatidylinositol-5-phosphate 4-kinase, type II, alpha (PIP5K2A). Pflugers Arch. 2014;466:1885-97 pubmed publisher
Maguire E, Mitchell E, Greig S, Corteen N, Balfour D, Swinny J, et al. Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons: a sensitive target for ethanol. Neuropsychopharmacology. 2014;39:1232-44 pubmed publisher
Chen Z, Cooper B, Kalla S, Varoqueaux F, Young S. The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse. J Neurosci. 2013;33:8336-51 pubmed publisher
Thanawala M, Regehr W. Presynaptic calcium influx controls neurotransmitter release in part by regulating the effective size of the readily releasable pool. J Neurosci. 2013;33:4625-33 pubmed publisher
Soskis M, Ho H, Bloodgood B, Robichaux M, Malik A, Ataman B, et al. A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development. Nat Neurosci. 2012;15:1645-54 pubmed publisher
Oh M, Kim J, Safaee M, Kaur G, Sun M, Kaur R, et al. Overexpression of calcium-permeable glutamate receptors in glioblastoma derived brain tumor initiating cells. PLoS ONE. 2012;7:e47846 pubmed publisher
Harms J, Benveniste M, Maclean J, Partin K, Jamieson C. Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy. Neuropharmacology. 2013;64:45-52 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Lee J, Ho W, Lee S. Actin-dependent rapid recruitment of reluctant synaptic vesicles into a fast-releasing vesicle pool. Proc Natl Acad Sci U S A. 2012;109:E765-74 pubmed publisher
Kopach O, Kao S, Petralia R, Belan P, Tao Y, Voitenko N. Inflammation alters trafficking of extrasynaptic AMPA receptors in tonically firing lamina II neurons of the rat spinal dorsal horn. Pain. 2011;152:912-23 pubmed publisher
Smejkalova T, Woolley C. Estradiol acutely potentiates hippocampal excitatory synaptic transmission through a presynaptic mechanism. J Neurosci. 2010;30:16137-48 pubmed publisher
Kong S, Qian B, Liu J, Fan M, Chen G, Wang Y. Cyclothiazide induces seizure behavior in freely moving rats. Brain Res. 2010;1355:207-13 pubmed publisher
Soto D, Coombs I, Renzi M, Zonouzi M, Farrant M, Cull Candy S. Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5. Nat Neurosci. 2009;12:277-85 pubmed publisher
Bagnall M, McElvain L, Faulstich M, du Lac S. Frequency-independent synaptic transmission supports a linear vestibular behavior. Neuron. 2008;60:343-52 pubmed publisher
Menuz K, Kerchner G, O Brien J, Nicoll R. Critical role for TARPs in early development despite broad functional redundancy. Neuropharmacology. 2009;56:22-9 pubmed publisher
Takayasu Y, Iino M, Shimamoto K, Tanaka K, Ozawa S. Glial glutamate transporters maintain one-to-one relationship at the climbing fiber-Purkinje cell synapse by preventing glutamate spillover. J Neurosci. 2006;26:6563-72 pubmed
Bender V, Bender K, Brasier D, Feldman D. Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex. J Neurosci. 2006;26:4166-77 pubmed
Pieri M, Severini C, Amadoro G, Carunchio I, Barbato C, Ciotti M, et al. AMPA receptors are modulated by tachykinins in rat cerebellum neurons. J Neurophysiol. 2005;94:2484-90 pubmed
product information
master code :
713
SKU :
0713/10
product name :
Cyclothiazide
unit size :
10 mg (also 50 mg)
description :
Positive allosteric modulator of AMPA receptors; inhibits AMPA desensitization
target :
AMPA Receptor Modulators
category :
Small Molecules
purity :
98%
observed molecular weight :
389.87
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Cyclothiazide is a positive allosteric modulator of AMPA receptors that potently inhibits AMPA receptor desensitization. Selective for the flip variant of each of the four receptor subunits.
top caption :
Positive allosteric modulator of AMPA receptors; inhibits AMPA desensitization
extended description :
Positive allosteric modulator of AMPA receptors; inhibits AMPA desensitization
chemical name text :
6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiazidiazine-7-sulfonamide-1,1-dioxide
formula :
C14H16ClN3O4S2
formula text :
C14H16ClN3O4S2
cas num :
2259-96-3
USD :
112 USD
product details :
Positive allosteric modulator of AMPA receptors; inhibits AMPA desensitization
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK