Anpirtoline hydrochloride | Tocris Bioscience 0703 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Anpirtoline hydrochloride

catalog :

0703

quantity :

10 mg (also 50 mg)

price :

181 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Gadgaard C, Jensen A. Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay. Biochem Pharmacol. 2020;175:113870 pubmed publisher
Carvalho Dias E, Miranda A, Martinho O, Mota P, Costa A, Nogueira Silva C, et al. Serotonin regulates prostate growth through androgen receptor modulation. Sci Rep. 2017;7:15428 pubmed publisher
Müller T, Dürk T, Blumenthal B, Grimm M, Cicko S, Panther E, et al. 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS ONE. 2009;4:e6453 pubmed publisher

product information

brand :

Tocris

master code :

0703

SKU :

0703/10

product name :

Anpirtoline hydrochloride

description :

Highly potent 5-HT1B agonist; also 5-HT3 antagonist

target :

5-HT1B Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

265.2

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Highly potent 5-HT1B receptor agonist (Ki values are 28, 150 and 1490 nM at 5-HT1B, 5-HT1A and 5-HT2 receptors respectively). Decreases central serotonin synthesis and attenuates aggressive behavior in vivo . Also acts as an antagonist at 5-HT3 receptors (Ki = 29.5 nM) and is brain penetrant.

catalog number base :

703

product keywords :

potent 5-HT1B agonists 5-HT3 antagonists Serotonin Receptors 5-HT1B Receptors 0703,

extended description :

Highly potent 5-HT1B agonist; also 5-HT3 antagonist

chemical name text :

6-Chloro-2-[piperidinyl-4-thio]pyridine hydrochloride

formula :

C 10 H 13 ClN 2 S.HCl

formula text :

C10H13ClN2S.HCl

cas num :

99201-87-3

2020 USD :

175

2021 USD :

181 USD

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage