0703/10 | Tocris Bioscience 0703/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

0703/10

catalog :

0703/10

quantity :

10 mg (also 50 mg)

price :

203 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Gadgaard C, Jensen A. Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay. Biochem Pharmacol. 2020;175:113870 pubmed publisher
Carvalho Dias E, Miranda A, Martinho O, Mota P, Costa A, Nogueira Silva C, et al. Serotonin regulates prostate growth through androgen receptor modulation. Sci Rep. 2017;7:15428 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Müller T, Dürk T, Blumenthal B, Grimm M, Cicko S, Panther E, et al. 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS ONE. 2009;4:e6453 pubmed publisher

product information

master code :

703

SKU :

0703/10

product name :

Anpirtoline hydrochloride

unit size :

10 mg (also 50 mg)

description :

Highly potent 5-HT1B agonist; also 5-HT3 antagonist

target :

5-HT1B Receptor Agonists

category :

Small Molecules

purity :

99%

observed molecular weight :

265.2

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Anpirtoline hydrochloride is a highly potent 5-HT1B receptor agonist (Ki values are 28, 150 and 1490 nM at 5-HT1B, 5-HT1A and 5-HT2 receptors respectively). Decreases central serotonin synthesis and attenuates aggressive behavior in vivo . Also acts as an antagonist at 5-HT3 receptors (Ki = 29.5 nM) and is brain penetrant.

top caption :

Highly potent 5-HT1B agonist; also 5-HT3 antagonist

extended description :

Highly potent 5-HT1B agonist; also 5-HT3 antagonist

chemical name text :

6-Chloro-2-[piperidinyl-4-thio]pyridine hydrochloride

formula :

C10H13ClN2S.HCl

formula text :

C10H13ClN2S.HCl

cas num :

99201-87-3

USD :

203 USD

product details :

Highly potent 5-HT1B agonist; also 5-HT3 antagonist

storage :

Desiccate at +4░C

more info or order :

Tocris Bioscience product webpage