0695/50 | Tocris Bioscience 0695/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

0695/50

catalog :

0695/50

quantity :

50 mg

price :

104 USD

more info or order :

Tocris Bioscience product webpage

citations: 10

Reference
Li X, Tao Y, Bradley R, Du Z, Tao Y, Kong L, et al. Fast Generation of Functional Subtype Astrocytes from Human Pluripotent Stem Cells. Stem Cell Reports. 2018;11:998-1008 pubmed publisher
Bohnenpoll T, Weiss A, Labuhn M, Lüdtke T, Trowe M, Kispert A. Retinoic acid signaling maintains epithelial and mesenchymal progenitors in the developing mouse ureter. Sci Rep. 2017;7:14803 pubmed publisher
Jaako K, Waniek A, Parik K, Klimaviciusa L, Aonurm Helm A, Noortoots A, et al. Prolyl endopeptidase is involved in the degradation of neural cell adhesion molecules in vitro. J Cell Sci. 2016;129:3792-3802 pubmed
Lewis H, Liddle J, Coote J, Atkinson S, Barker M, Bax B, et al. Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. Nat Chem Biol. 2015;11:189-91 pubmed publisher
Whelan J, Wang L, Chen J, Metts M, Nasser T, McGoldrick L, et al. Retinoids induce integrin-independent lymphocyte adhesion through RAR-Î± nuclear receptor activity. Biochem Biophys Res Commun. 2014;454:537-42 pubmed publisher
Kang M, Han Y. Differentiation of human pluripotent stem cells into nephron progenitor cells in a serum and feeder free system. PLoS ONE. 2014;9:e94888 pubmed publisher
Yang J, Wang J, Pan L, Li H, Rao C, Zhang X, et al. BMP4 is required for the initial expression of MITF in melanocyte precursor differentiation from embryonic stem cells. Exp Cell Res. 2014;320:54-61 pubmed publisher
Davies W, Tay B, Zheng L, Danks J, Brenner S, Foster R, et al. Evolution and functional characterisation of melanopsins in a deep-sea chimaera (elephant shark, Callorhinchus milii). PLoS ONE. 2012;7:e51276 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Han A, Heo H, Kwon Y. Berberine promotes axonal regeneration in injured nerves of the peripheral nervous system. J Med Food. 2012;15:413-7 pubmed publisher

product information

master code :

695

SKU :

0695/50

product name :

Retinoic acid

unit size :

50 mg

description :

Endogenous retinoic acid receptor agonist

target :

Retinoic Acid Receptor Agonists

category :

Small Molecules

purity :

98%

observed molecular weight :

300.44

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Retinoic acid is an endogenous agonist for retinoic acid receptors (IC50 = 14 nM for RAR , RAR and RAR receptors). Retinoic acid specifies anterior-posterior patterning of neural progenitors. It promotes differentiation of mouse embryonic stem cells (ESCs) into adipocytes, neurons and glia in vitro . Retinoic acid also promotes differentiation of human PSCs into dopaminergic neurons and maturation of retinal organoids. It is a proposed ligand of ROR (Kd = 280 nM). Activates autophagy. . For more information about how Retinoic acid may be used, see our protocols: Generation of cells from hPSCs, Cultivating Cerebral Organoids . . Retinoic acid synthesized to Ancillary Material Grade also available.

top caption :

iPSC differentiation with retinoic acid

extended description :

Endogenous retinoic acid receptor agonist

chemical name text :

3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2E,4E,6E,8E,-nonatetraenoic acid

formula :

C20H28O2

formula text :

C20H28O2

cas num :

302-79-4

USD :

104 USD

product details :

Endogenous retinoic acid receptor agonist

alt names :

Tretinoin,ATRA

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage