product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
0690/100
catalog :
0690/100
quantity :
100 mg
price :
111 USD
more info or order :
citations: 10
Reference
Harris N, Isaac A, Gunther A, Merkel K, MELCHIOR J, Xu M, et al. Dorsal BNST α2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors. J Neurosci. 2018;38:8922-8942 pubmed publisher
Devoto P, Flore G, Saba P, Frau R, Gessa G. Selective inhibition of dopamine-beta-hydroxylase enhances dopamine release from noradrenergic terminals in the medial prefrontal cortex. Brain Behav. 2015;5:e00393 pubmed publisher
Yuen E, Qin L, Wei J, Liu W, Liu A, Yan Z. Synergistic regulation of glutamatergic transmission by serotonin and norepinephrine reuptake inhibitors in prefrontal cortical neurons. J Biol Chem. 2014;289:25177-85 pubmed publisher
Cinelli E, Bongianni F, Pantaleo T, Mutolo D. Suppression of the cough reflex by α 2-adrenergic receptor agonists in the rabbit. Physiol Rep. 2013;1:e00122 pubmed publisher
Asiedu M, Mejia G, Ossipov M, Malan T, Kaila K, Price T. Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice. J Pain. 2012;13:546-54 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Kim J, Cowan A, Lisek R, Raymondi N, Rosenthal A, Hirsch D, et al. Icilin-evoked behavioral stimulation is attenuated by alpha?-adrenoceptor activation. Brain Res. 2011;1384:110-7 pubmed publisher
Liu P, Okun A, Ren J, Guo R, Ossipov M, Xie J, et al. Ongoing pain in the MIA model of osteoarthritis. Neurosci Lett. 2011;493:72-5 pubmed publisher
Okun A, Defelice M, Eyde N, Ren J, Mercado R, King T, et al. Transient inflammation-induced ongoing pain is driven by TRPV1 sensitive afferents. Mol Pain. 2011;7:4 pubmed publisher
Garzón J, de la Torre Madrid E, Rodríguez Muñoz M, Vicente Sánchez A, Sánchez Blázquez P. Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine. Mol Pain. 2009;5:11 pubmed publisher
product information
master code :
690
SKU :
0690/100
product name :
Clonidine hydrochloride
unit size :
100 mg
description :
2 agonist. Also I1 ligand
target :
Adrenergic alpha-2 Receptor Agonists
category :
Small Molecules
purity :
99%
observed molecular weight :
266.56
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Clonidine hydrochloride is a prototypical I1 imidazoline receptor ligand. 2-adrenergic receptor agonist. Antihypertensive. Also thought to enhance autophagy; shown to increase LC3-II levels in PC12 cells.
top caption :
2 agonist. Also I1 ligand
extended description :
2 agonist. Also I1 ligand
chemical name text :
2-[(2,6-Dichlorophenyl)amino-2-imidazoline hydrochloride
formula :
C9H9Cl2N3.HCl
formula text :
C9H9Cl2N3.HCl
cas num :
4205-91-8
USD :
111 USD
product details :
2 agonist. Also I1 ligand
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK