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company name :
Tocris Bioscience
product type :
chemical
product name :
0681/10
catalog :
0681/10
quantity :
10 mg (also 50 mg)
price :
232 USD
more info or order :
citations: 7
Reference
Harding C, Mattheis C, Mousnier A, Oates C, Hartland E, Frankel G, et al. LtpD is a novel Legionella pneumophila effector that binds phosphatidylinositol 3-phosphate and inositol monophosphatase IMPA1. Infect Immun. 2013;81:4261-70 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
De Meyer I, Martinet W, Van Hove C, Schrijvers D, Hoymans V, Van Vaeck L, et al. Inhibition of inositol monophosphatase by lithium chloride induces selective macrophage apoptosis in atherosclerotic plaques. Br J Pharmacol. 2011;162:1410-23 pubmed publisher
Sarkar S, Krishna G, Imarisio S, Saiki S, O Kane C, Rubinsztein D. A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin. Hum Mol Genet. 2008;17:170-8 pubmed
Criollo A, Maiuri M, Tasdemir E, Vitale I, Fiebig A, Andrews D, et al. Regulation of autophagy by the inositol trisphosphate receptor. Cell Death Differ. 2007;14:1029-39 pubmed
Sarkar S, Floto R, Berger Z, Imarisio S, Cordenier A, Pasco M, et al. Lithium induces autophagy by inhibiting inositol monophosphatase. J Cell Biol. 2005;170:1101-11 pubmed
Westfall T, Brimeyer R, Twedt J, Gladon J, Olberding A, Furutani Seiki M, et al. Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/beta-catenin activity. J Cell Biol. 2003;162:889-98 pubmed
product information
master code :
681
SKU :
0681/10
product name :
L-690,330
unit size :
10 mg (also 50 mg)
description :
Inositol monophosphatase inhibitor
target :
Inositol Lipid Inhibitors
category :
Small Molecules
observed molecular weight :
298.13
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
L-690,330 is a potent inhibitor of inositol monophophatase; stable to hydrolysis. Induces autophagy in COS-7 cells independently of mTOR inhibition.
top caption :
Inositol monophosphatase inhibitor
extended description :
Inositol monophosphatase inhibitor
chemical name text :
[1-(4-Hydroxyphenoxy)ethylidene]bisphosphonic acid
formula :
C8H12O8P2
formula text :
C8H12O8P2
cas num :
142523-38-4
USD :
232 USD
product details :
Inositol monophosphatase inhibitor
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK